Ketorolac

A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)

Also Known As:

Networked: 1064 relevant articles (205 outcomes, 237 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eisenach, James C: 11 articles (01/2015 - 03/2002)
2.	Waterbury, L David: 7 articles (12/2011 - 08/2004)
3.	Yaksh, Tony L: 6 articles (01/2013 - 10/2002)
4.	Hubbard, Richard C: 6 articles (10/2004 - 01/2002)
5.	Forget, Patrice: 5 articles (03/2014 - 06/2010)
6.	Kim, Stephen J: 5 articles (01/2014 - 09/2008)
7.	Curry, Regina: 4 articles (10/2014 - 10/2002)
8.	De Kock, Marc: 4 articles (03/2014 - 06/2010)
9.	Carr, Daniel B: 4 articles (11/2012 - 12/2005)
10.	Bucci, Frank A: 4 articles (12/2011 - 09/2008)

Related Diseases

1.	Pain (Aches) 05/01/1994 - "Ketorolac was most effective in patients who had bone or visceral pain. " 10/01/2003 - "2. In the present study, a clinically relevant CP response of pain tolerance was used to assess the previously undescribed analgesic efficacy of the potent NSAID ketorolac (10 mg, p.o.), on CP pain across gender in a sample of normal subjects (n = 50). " 08/01/2004 - "Ketorolac patients reported significantly greater pain relief than vehicle patients throughout the study (P<.001). " 03/01/2011 - "Only 1 outcome achieved significant improvement; there was 1 day of significant pain reduction in the ketorolac groups (median NRS 6 to 4, P=0.002). " 01/01/2011 - "Significant improvement regarding pain assessment tools was observed in the ketorolac group by the addition of ketorolac to HA as compared with the HA group within 16 weeks of follow-up (p < 0.05). "
2.	Postoperative Pain 03/01/1994 - "Thus, perioperative ketorolac infusion improved the quality of postoperative pain relief, and had no major influence on endocrine-metabolic response and no negative influences on hemostatic and renal functions. " 06/01/2012 - "Intranasal ketorolac was effective in providing short-term relief from postoperative pain in four well designed, phase II or III trials. " 01/01/1990 - "Intravenous ketorolac is effective for the treatment of postoperative pain." 05/01/1987 - "This study shows ketorolac to be a safe and effective analgesic for relief of postoperative pain." 02/01/1994 - "Ketorolac, when administered intramuscularly or orally, is a safe and effective analgesic agent for the short-term management of acute postoperative pain and can be used as an alternative to opioid therapy."
3.	Cataract (Cataracts) 12/01/2011 - "Long-term postoperative use of topical ketorolac drops with the preservation of posterior capsule was found to be effective for the prevention of PCO in pediatric cataract surgery, at least during the period of this study." 06/01/2009 - "In this single-center, investigator-masked trial, patients undergoing cataract surgery were randomized to receive either ketorolac 0.4% q.i.d. " 01/01/2013 - "Prophylactic postoperative ketorolac 0.4% may have a role in reducing the frequency and severity of CME in diabetic eyes post-cataract surgery." 01/01/2013 - "Prophylactic postoperative ketorolac improves outcomes in diabetic patients assigned for cataract surgery." 03/01/2011 - "Two multicenter, double-masked studies randomized 511 cataract surgery patients (2:1) to receive twice-daily ketorolac 0.45% or vehicle in the operative eye for 16 days, beginning 1 day before surgery. "
4.	Inflammation 01/01/2006 - "Aqueous, oil, and ointment formulations of ketorolac: efficacy against prostaglandin E2-induced ocular inflammation and safety: a technical note." 09/01/2009 - "Present studies examine effects of the nonsteroidal anti-inflammatory drug, ketorolac, upon RV inflammation and dysfunction. " 04/01/2013 - "In addition, PRP and ketorolac showed a 1.4- to 2.5-fold reduction (P < .05) in cellular inflammation markers over the control. " 04/01/2011 - "The difference in inflammation suppression may be due to differences in tissue concentrations and/or greater COX-1 suppression by ketorolac 0.45%." 01/01/2011 - "The addition of ketorolac did not seem to offer any additional benefit in terms of inflammation-related signs. "
5.	Renal Colic 11/01/1999 - "Based on their findings and review of the literature, the authors recommend that intravenous ketorolac be used as the first-line treatment for acute renal colic in patients in whom the medication is not contraindicated." 05/01/1993 - "The objective of this study was to report the authors' experience using intravenous ketorolac (Syntex Laboratories, Palo Alto, CA) as an analgesic in the treatment of renal colic in a convenience sample at three suburban community hospital emergency departments. " 04/01/1990 - "The results of the study show that intramuscular ketorolac is efficacious in the treatment of renal colic." 09/01/2014 - "This may reflect the inclusion of ketorolac in the renal colic order set. " 09/01/2014 - "The introduction of CPOE is associated with an increase in ketorolac use for ED renal colic visits. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Diclofenac (SR 38)
3.	Meperidine (Pethidine)
4.	Lidocaine (Xylocaine)
5.	Fentanyl (Sublimaze)
6.	Ibuprofen (Motrin)
7.	Tramadol
8.	Ketorolac Tromethamine (Acular)
9.	Indomethacin (Indometacin)
10.	Acetaminophen (Paracetamol)

Related Therapies and Procedures

1.	Analgesia
2.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
3.	Injections
4.	Phacoemulsification
5.	Intraocular Lens Implantation