Ketorolac

A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)

Also Known As:

Networked: 1670 relevant articles (320 outcomes, 418 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eisenach, James C: 11 articles (01/2015 - 03/2002)
2.	Forget, Patrice: 10 articles (11/2020 - 06/2010)
3.	Donnenfeld, Eric D: 8 articles (01/2022 - 10/2002)
4.	Yaksh, Tony L: 8 articles (01/2020 - 10/2002)
5.	Waterbury, L David: 8 articles (01/2018 - 08/2004)
6.	Friedman, Benjamin W: 6 articles (01/2022 - 12/2008)
7.	Hudson, Laurie G: 6 articles (01/2021 - 01/2015)
8.	Wandinger-Ness, Angela: 6 articles (01/2021 - 01/2015)
9.	De Kock, Marc: 6 articles (11/2020 - 06/2010)
10.	Maruta, Hiroshi: 6 articles (06/2020 - 01/2017)

Related Diseases

1.	Pain (Aches) 01/01/2021 - "The available evidence indicates that postoperative intravenous ketorolac administration may offer substantial pain relief for most patients, but further research may impact this estimate. " 02/01/2019 - "In addition, its rate of complete relief from pain was twice as much as that of ketorolac. " 02/01/1993 - "The following case demonstrates marked improvement in treatment-resistant RSD pain with intramuscular ketorolac." 08/01/2004 - "Ketorolac patients reported significantly greater pain relief than vehicle patients throughout the study (P<.001). " 03/01/2011 - "Only 1 outcome achieved significant improvement; there was 1 day of significant pain reduction in the ketorolac groups (median NRS 6 to 4, P=0.002). "
2.	Postoperative Pain 06/01/2012 - "Intranasal ketorolac was effective in providing short-term relief from postoperative pain in four well designed, phase II or III trials. " 01/01/1990 - "Intravenous ketorolac is effective for the treatment of postoperative pain." 04/01/2022 - "Administration of intra-articular Ketorolac injection is safe and effective way of achieving postoperative pain relief after arthroscopic knee surgery." 03/01/2022 - "Intravenous ketorolac (IVK) is an effective and safe medication to reduce postoperative pain in the setting of oculofacial surgery. " 08/01/1992 - "Ketorolac is useful in the management of short term, moderate to severe postoperative pain. "
3.	Renal Colic 11/01/1999 - "Based on their findings and review of the literature, the authors recommend that intravenous ketorolac be used as the first-line treatment for acute renal colic in patients in whom the medication is not contraindicated." 04/01/1990 - "The results of the study show that intramuscular ketorolac is efficacious in the treatment of renal colic." 11/21/2023 - "Atomized Intranasal Ketorolac Versus Intravenous Ketorolac for the Treatment of Severe Renal Colic in the Emergency Department: A Double-Blind, Randomized Controlled Trial." 01/01/2021 - "Comparison of intravenous ketorolac at three doses for treating renal colic in the emergency department: A noninferiority randomized controlled trial." 09/01/2014 - "This may reflect the inclusion of ketorolac in the renal colic order set. "
4.	Cataract (Cataracts) 06/01/2009 - "In this single-center, investigator-masked trial, patients undergoing cataract surgery were randomized to receive either ketorolac 0.4% q.i.d. " 01/01/2017 - "Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration." 01/01/2013 - "Prophylactic postoperative ketorolac 0.4% may have a role in reducing the frequency and severity of CME in diabetic eyes post-cataract surgery." 01/01/2013 - "Prophylactic postoperative ketorolac improves outcomes in diabetic patients assigned for cataract surgery." 03/01/2011 - "Two multicenter, double-masked studies randomized 511 cataract surgery patients (2:1) to receive twice-daily ketorolac 0.45% or vehicle in the operative eye for 16 days, beginning 1 day before surgery. "
5.	Migraine Disorders (Migraine) 11/01/1993 - "Ketorolac as a rapid and effective treatment of migraine headache: evaluations by patients." 03/01/2020 - "This study assessed for efficacy of CAMBIA® as an alternative outpatient treatment for refractory migraine to parenteral ketorolac. " 01/01/2022 - "This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache. " 01/01/2022 - "Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis." 01/01/2022 - "We searched databases Cochrane Central Register of Controlled Trials (CENTRAL), Medline, and Google Scholar up to January 2021 and identified randomized controlled trials comparing ketorolac to any other medications in treating patients presenting with migraine headache. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Morphine (MS Contin)
3.	Diclofenac (SR 38)
4.	Lidocaine (Xylocaine)
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
6.	Ibuprofen (Motrin)
7.	Opioid Analgesics (Opioids)
8.	Meperidine (Pethidine)
9.	Ophthalmic Solutions (Eye Drops)
10.	Fentanyl (Sublimaze)

Related Therapies and Procedures

1.	Analgesia
2.	Injections
3.	Therapeutics
4.	Premedication
5.	Phacoemulsification