Glia Maturation Factor (GMF)

A factor identified in the brain that influences the growth and differentiation of NEURONS and NEUROGLIA. Glia maturation factor beta is the 17-kDa polypeptide product of the GMFB gene and is the principal component of GLIA MATURATION FACTOR.

Also Known As:

Networked: 110 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zaheer, Asgar: 16 articles (05/2015 - 06/2002)
2.	Zaheer, Smita: 10 articles (05/2015 - 01/2007)
3.	Sahu, Shailendra K: 8 articles (02/2012 - 01/2007)
4.	Thangavel, Ramasamy: 7 articles (05/2015 - 05/2008)
5.	Wu, Yanghong: 7 articles (01/2013 - 05/2007)
6.	Kempuraj, Duraisamy: 6 articles (05/2015 - 01/2013)
7.	Zaheer, A: 5 articles (09/2014 - 02/2000)
8.	Yang, Baoli: 5 articles (05/2008 - 01/2007)
9.	Iamshanov, V A: 4 articles (01/2007 - 01/2003)
10.	Khan, Mohammad Moshahid: 3 articles (05/2015 - 01/2013)

Related Diseases

1.	Glioma (Gliomas) 10/01/1986 - "In this study we report the effect of GMF on two glioma cell lines: the C6 line, of rodent origin, and the HG-1 line, of human origin. " 05/19/2000 - "C6 glioma cells were transfected in vitro with GMF utilizing an adenovirus vector. " 02/01/2000 - "Activation of nuclear factor-kappaB in C6 rat glioma cells after transfection with glia maturation factor." 12/01/1990 - "In contrast to astrocytes, we failed to detect GMF-beta on the surface of C6 glioma cells, although these cells, like astrocytes, possess endogenous intracellular GMF-beta and are also responsive to GMF-beta added to the medium. " 05/01/1987 - "Using the same monoclonal antibody, the GMF-like factor in astroblasts and C6 glioma cells was characterized by immunofluorescence, immunoadsorption and immunoblotting. "
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2007 - "Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice." 12/01/2007 - "Glia maturation factor regulation of STAT expression: a novel mechanism in experimental autoimmune encephalomyelitis." 05/04/2007 - "Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis." 02/10/2011 - "Suppression of neuro inflammation in experimental autoimmune encephalomyelitis by glia maturation factor antibody." 02/01/2012 - "Clinical course of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor."
3.	Demyelinating Diseases (Demyelinating Disease) 12/01/2010 - "Drastically reduced infiltrates (15%) and demyelination (10%) were found in GMF-KO mice that developed reduced severity of EAE. " 12/01/2010 - "Upon GMF reintroduction in GMF-KO mice, MOG(35-55) immunization caused extensive monocytes infiltration (48%) and demyelination (46%), similar to that observed in the immunized Wt mice. " 02/10/2011 - "Histological analysis of the spinal cord and brain showed severe inflammation and demyelination in the control antibody-treated mice whereas significantly reduced inflammation and demyelination was detected in GMF-antibody-treated mice at days 8, 16, and 24 post immunization. " 12/01/2010 - "Our results show that MOG(35-55) immunization caused only a muted EAE and inflammation/demyelination in mice lacking endogenous GMF. "
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2013 - "In the present study, we examined the expressions of GMF in triple-transgenic Alzheimer's disease (3xTg-AD) mice. " 10/27/2011 - "In the present study, we demonstrate, for the first time, a significant upregulation of the GMF protein in various regions of Alzheimer's disease (AD) brains compared with age-matched non-demented (ND) control brains. " 09/01/2013 - "Glia maturation factor expression in entorhinal cortex of Alzheimer's disease brain." 08/01/2013 - "Glia maturation factor expression in hippocampus of human Alzheimer's disease." 01/01/2013 - "Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice."
5.	Inguinal Hernia (Direct Inguinal Hernia) 07/01/2013 - "The aim of this study was to systematically analyze the randomized trials comparing tacker mesh fixation with glue mesh fixation (GMF) in laparoscopic inguinal hernia repair (LIHR). " 01/01/2013 - "To systematically analyse the trials comparing suture mesh fixation (SMF) versus glue mesh fixation (GMF) in open inguinal hernia repair (OIHR). "

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Ethanol (Ethyl Alcohol)
4.	Glia Maturation Factor (GMF)
5.	Complementary DNA (cDNA)
6.	Anti-Bacterial Agents (Antibiotics)
7.	Conditioned Culture Media
8.	Cytokines
9.	DNA (Deoxyribonucleic Acid)
10.	p38 Mitogen-Activated Protein Kinases

Related Therapies and Procedures

1.	Sutures (Suture)
2.	Activities of Daily Living (ADL)
3.	Cyclotrons
4.	Cardiopulmonary Resuscitation (CPR)
5.	Intraperitoneal Injections