ErbB-3 Receptor

A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.

Also Known As:

Receptor, ErbB-3; Proto-Oncogene Protein c-erbB-3; Proto-Oncogene Proteins erbB-3; Proto-oncogene-like Protein c-ErbB-2; Tyrosine Kinase-type Cell Surface Receptor HER3; HER 3 Proto Oncogene Protein; Protein c-ErbB-2, Proto-oncogene-like; Proto Oncogene Protein c erbB 3; Proto Oncogene Protein erbB 3; Proto Oncogene Proteins erbB 3; Proto oncogene like Protein c ErbB 2; Proto-Oncogene Protein, HER-3; Receptor, ErbB 3; Tyrosine Kinase type Cell Surface Receptor HER3; c erbB 3 Protein; c-ErbB-2, Proto-oncogene-like Protein; c-erbB-3, Proto-Oncogene Protein; erbB 3 Protein; erbB-3, Proto-Oncogene Protein; erbB-3, Proto-Oncogene Proteins; HER-3 Proto-Oncogene Protein; Proto-Oncogene Protein erbB-3; c-erbB-3 Protein; erbB-3 Protein

Networked: 16 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Backs, Johannes: 1 article (03/2013)
2.	Bauer, Andrea: 1 article (03/2013)
3.	Dösch, Andreas: 1 article (03/2013)
4.	Ehlermann, Philipp: 1 article (03/2013)
5.	Fischer, Simon: 1 article (03/2013)
6.	Franke, Jennifer: 1 article (03/2013)
7.	Frese, Karen S: 1 article (03/2013)
8.	Haas, Jan: 1 article (03/2013)
9.	Hardt, Stefan: 1 article (03/2013)
10.	Hassel, Sarah: 1 article (03/2013)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2000 - "These findings demonstrate that erbB-3 protein expression could serve as a prognostic factor in colorectal malignancies." 01/01/1998 - "The c-erbB-3 protein is expressed in normal breast epithelial cells and has been reported to be present at high levels in some cancers but at normal levels or at lower than normal levels in some others. " 11/01/1992 - "Immunohistochemical expression of the c-erbB-3 protein appears to be a relatively common event in adenocarcinomas, and further studies are now warranted to establish the role of the c-erbB-3 protein in neoplasia." 12/15/2000 - "Overexpression of c-erbB-3 protein correlated with increased PCNA labeling index, indicating that c-erbB-3 may contribute to malignant transformation and tumor growth. " 12/15/2000 - "In contrast, 7 (39%) of 18 VHs, 25 (84%) of 31 VCs, and all (100%) of 12 V-WSCCs demonstrated overexpression of c-erbB-3 protein with increased expression of PCNA in some premalignant epithelial cells and many tumor cells. "
2.	Carcinoma (Carcinomatosis) 11/01/1992 - "In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. " 02/13/2008 - "In mammary carcinoma cells, we evidenced that the alpha6beta4 integrin strongly influence Akt phosphorylation through ErbB-3 protein regulation. " 12/15/2000 - "To determine whether c-erbB-3 expression could serve as an indicator of progression from premalignant to malignant transformation and of prognoses in patients with oral carcinoma, the authors examined the relation between the expression of c-erbB-3 protein and cell proliferation activity during the development of oral verrucous carcinoma (VC). " 06/15/1999 - "Paradoxically, the neuregulin receptor ErbB-3 is devoid of catalytic activity, but its heterodimerization with other ErbBs, particularly the ligand-less ErbB-2 oncoprotein of carcinomas, reconstitutes superior mitogenic and transforming activities. "
3.	Adenocarcinoma 04/01/2000 - "Adenocarcinomas of the colon were positive for erbB-3 protein in 78% of samples examined. " 04/01/2000 - "Expression of erbB-3 protein in colorectal adenocarcinoma: correlation with poor survival." 11/01/1992 - "c-erbB-3 protein expression was then examined in a variety of adenocarcinomas. " 11/01/1992 - "Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas." 11/01/1992 - "Immunohistochemical expression of the c-erbB-3 protein appears to be a relatively common event in adenocarcinomas, and further studies are now warranted to establish the role of the c-erbB-3 protein in neoplasia."
4.	Breast Neoplasms (Breast Cancer) 07/01/1996 - "In conclusion this study found variable expression of c-erbB-3 protein in human breast carcinoma and an association with some recognised prognostic factors in those patients with primary operable breast carcinoma. " 09/01/1994 - "c-erbB-3 protein expression in human breast cancer: comparison with other tumour variables and survival." 07/01/1996 - "A series of 346 patients with primary operable breast cancer and a series of 145 patients with advanced breast cancer were investigated for c-erbB-3 protein expression using the monoclonal antibody RTJ1. " 11/01/1992 - "c-erbB-3 protein was detected in a series of 13 out of 14 primary breast carcinomas, 3 of 5 gastric adenocarcinomas, 8 of 9 colonic adenocarcinomas, 2 of 9 prostatic adenocarcinomas, 0 of 6 renal cell carcinomas, 1 of 4 primary lung adenocarcinomas, and 5 of 7 endometrial adenocarcinomas. "
5.	Chronic Pancreatitis 11/01/1992 - "In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. "

Related Drugs and Biologics

1.	Integrin alpha6beta4
2.	Neuregulins
3.	Proliferating Cell Nuclear Antigen (PCNA)
4.	Purinergic P1 Receptors (Adenosine Receptor)
5.	Oncogene Proteins (Oncogene Protein)
6.	Tyrosine (L-Tyrosine)
7.	Proteins (Proteins, Gene)
8.	Phosphotransferases (Kinase)
9.	Paraffin
10.	Ligands