Neuregulin-1 (Neuregulin 1)

A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.

Also Known As:

Networked: 695 relevant articles (8 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lupu, Ruth: 13 articles (11/2015 - 08/2002)
2.	Karl, Tim: 12 articles (05/2015 - 02/2008)
3.	Ford, Byron D: 11 articles (10/2015 - 09/2004)
4.	Carroll, Steven L: 10 articles (04/2014 - 01/2003)
5.	Karl, T: 9 articles (09/2014 - 06/2007)
6.	Law, Amanda J: 9 articles (09/2014 - 04/2006)
7.	Nawa, Hiroyuki: 9 articles (01/2014 - 09/2006)
8.	Waddington, John L: 9 articles (05/2012 - 01/2006)
9.	Menendez, Javier A: 8 articles (11/2015 - 01/2005)
10.	Huang, Xu-Feng: 8 articles (05/2015 - 08/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 05/01/2015 - "Substantial evidence from human post-mortem and genetic studies has linked the neurotrophic factor neuregulin 1 (NRG1) to the pathophysiology of schizophrenia. " 09/01/2014 - "Thus, in this study, we systematically compared the established behavioural phenotype of a validated mouse model for the schizophrenia risk gene neuregulin 1 (TM Nrg1 HET) kept in FILTER housing with Nrg1 mutant mice raised in IVC systems. " 05/01/2014 - "Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches." 01/01/2014 - "Accumulating evidence from human genetic studies has suggested several functional candidate genes that might contribute to susceptibility to schizophrenia, including AKT1 and neuregulin 1 (NRG1). " 09/01/2013 - "The biological functions of the neuregulin 1 (NRG1) and ERBB4 genes have received much recent attention due to several studies showing associations between these genes and schizophrenia. "
2.	Breast Neoplasms (Breast Cancer) 07/01/2005 - "Pretreating the breast cancer cells with alpha-HER3ECD prior to Heregulin stimulation caused significant reduction of the migratory and proliferative properties. " 11/15/2013 - "In this study we examined the suppressing effects of extracellular domains of ErbB2, ErbB3, and ErbB4 (soluble ErbB (sErbB)) on heregulin β signaling in human breast cancer cell line MCF7. " 12/01/2000 - "Using in vitro models, recent studies have shown that HER-2 overexpression may not be a prerequisite for invasion of breast cancer cells, as HER-2 activation by heregulin, which binds to HER-3 or HER-4 and transphosphorylates HER in noninvasive breast cancer cells, could lead to increased motility, enhanced gelatinolytic activity, and invasion. " 11/01/2015 - "Heregulin-driven ERBB3 signaling has been implicated as a mechanism of resistance to cytotoxic and antiendocrine therapies in preclinical breast cancer models. " 02/28/2015 - "Moreover, heregulin induced breast cancer cell transmigration across a tight barrier of primary human brain microvascular endothelia. "
3.	Neoplasms (Cancer) 03/01/2007 - "ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence and progression. " 01/01/2000 - "The purpose of the present study was to elucidate the mechanisms by which anti-HER2 antibody and heregulin inhibit tumor growth. " 09/01/2015 - "This Position Paper of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology aims to: (1) define the distinctive etiopatogenetic features of cardiac toxicity induced by cancer therapy in humans, which include new aspects of mitochondrial function and oxidative stress, neuregulin-1 modulation through the ErbB receptor family, angiogenesis inhibition, and cardiac stem cell depletion and/or dysfunction; (2) review the new, more promising therapeutic strategies for cardioprotection, aimed to increase the survival of patients with severe antineoplastic-induced cardiotoxicity; (3) recommend the distinctive pathological features of cardiotoxicity induced by cancer therapy in humans that should be present in animal models used to identify or to test new cardioprotective therapies. " 03/01/2015 - "Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models." 02/28/2015 - "Collectively these data suggest mechanisms by which the HER3-HER2 dimer promotes development of metastatic tumors in the heregulin-rich brain microenvironment. "
4.	Mood Disorders (Mood Disorder) 06/01/2009 - "An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis." 04/01/2008 - "Although preliminary, linkage studies of psychotic BP show replicated evidence for suggestive genome-wide linkage to chromosomes 8p and 13q, which have been implicated in prior linkage studies of schizophrenia and BP. Association studies of psychotic BP and subtypes such as mood-incongruent psychotic BP have uncovered modest positive results for several candidate schizophrenia susceptibility genes, including dysbindin, DAOA/G30, Disrupted-in-Schizophrenia-1, and neuregulin 1. These tentative results are consistent with the hypothesis that the subphenotype of psychotic BP may represent a clinical manifestation of "overlap" genes between schizophrenia and mood disorder syndromes." 06/01/2009 - "As the neuregulin 1 (NRG1) gene has been associated with schizophrenia, we set out to investigate whether it is also associated with bipolar affective disorder, using a sample from Scotland, UK. "
5.	Heart Failure 05/04/2010 - "The purpose of this study was to assess the safety and efficacy of recombinant human neuregulin-1 (rhNRG-1) in chronic heart failure (CHF) patients. " 05/04/2010 - "A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure." 10/01/2014 - "Anti-remodeling and anti-fibrotic effects of the neuregulin-1β glial growth factor 2 in a large animal model of heart failure." 04/01/2014 - "Neuregulin-1 (NRG-1)/ErbB signaling in the heart is reported to have a crucial role in heart failure. " 04/01/2014 - "Central neuregulin-1/ErbB signaling modulates cardiac function via sympathetic activity in pressure overload-induced heart failure."

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