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Vigabatrin

An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA-AMINOBUTYRIC ACID. (From Martindale The Extra Pharmacopoeia, 31st ed)

Also Known As:

Aventis Brand of Vigabatrin; Hoechst Brand of Vigabatrin; Sabril; Sabrilex; Yamanouchi Brand of Vigabatrin; gamma-Vinyl-GABA; Acid, gamma-Vinyl-gamma-Aminobutyric; Vigabatrin Aventis Brand; Vigabatrin Hoechst Brand; Vigabatrin Yamanouchi Brand; gamma Vinyl GABA; gamma Vinyl gamma Aminobutyric Acid; gamma-Vinyl-gamma-Aminobutyric Acid; 4-Amino-5-hexenoic Acid

Networked: 856 relevant articles (130 outcomes, 194 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Chiron, Catherine: 10 articles (01/2015 - 09/2002)
2.	Luszczki, Jarogniew J: 10 articles (01/2014 - 01/2004)
3.	Westall, Carol A: 8 articles (12/2014 - 11/2003)
4.	Snead, O Carter: 7 articles (08/2015 - 01/2002)
5.	Dulac, Olivier: 7 articles (01/2015 - 09/2002)
6.	Silverman, Richard B: 6 articles (02/2015 - 09/2002)
7.	Edwards, Stuart W: 6 articles (09/2013 - 11/2004)
8.	Osborne, John P: 6 articles (09/2013 - 11/2004)
9.	Marson, Anthony G: 6 articles (01/2013 - 01/2008)
10.	Riikonen, Raili: 5 articles (05/2015 - 06/2004)

Related Diseases

1.	Infantile Spasms (West Syndrome) 03/01/2012 - "Clinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. " 05/01/2010 - "Vigabatrin is particularly effective for the treatment of patients with West syndrome; however, the patients need to be regularly monitored for the development of peripheral visual field defect. " 03/01/2008 - "Vigabatrin has proved to be effective against infantile spasms due to TSC. " 11/01/2003 - "This is a particular problem as vigabatrin is effective against infantile spasms. " 09/01/2002 - "Vigabatrin is an effective, well-tolerated treatment for infantile spasms. "
2.	Seizures (Seizure) 02/01/1993 - "Clinical efficacy of vigabatrin has been evaluated in controlled trials and appears to be most effective in complex partial seizures, producing a 50 percent or greater reduction in seizure frequency in approximately 50 percent of the adult patients studied. " 04/01/2000 - "Vigabatrin has been found most effective against complex partial and secondarily generalized tonic-clonic seizures in both adults and children. " 07/01/1988 - "From patients who showed a greater than 50% reduction in seizures (responders) or marked improvement in global performance, a third sample was taken at the end of the next 3-month phase, during which 3 g or 1.5 g gamma-vinyl GABA had been administered daily. " 12/01/1996 - "The results of this study indicate that vigabatrin, given in a daily dose of either 2 g or 3 g is significantly more effective than placebo in reducing seizure frequency among patients with partial seizures." 01/01/2011 - "Efficacy outcomes demonstrated that vigabatrin add-on therapy significantly reduced the frequency of seizures. "
3.	Epilepsy (Aura) 02/01/2012 - "Vigabatrin was effective for refractory childhood partial-onset epilepsy, and was not associated with symptomatic vision loss." 02/01/1993 - "Vigabatrin has been effective in patients with refractory epilepsy. " 01/01/1989 - "6. Vigabatrin thus appears to be a safe antiepileptic drug that may be effective in the treatment of severe epilepsy in children." 09/01/1994 - "To determine the efficacy of a new anti-epileptic medication vigabatrin in adults and children with drug-resistant epilepsy. " 12/01/2013 - "This study evaluated the efficacy of Vigabatrin in children with intractable epilepsy. "
4.	Tuberous Sclerosis (Bourneville's Disease) 03/01/2012 - "In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. " 01/01/2004 - "Vigabatrin has shown promise in treating IS patients, particularly those with tuberous sclerosis. " 07/01/1998 - "However, since 1990, some authors have reported the efficacy of vigabatrin (VGB), especially in cases related to tuberous sclerosis. " 02/01/1999 - "Paradoxically, in those without tuberous sclerosis complex, vigabatrin might be less efficacious than suggested by studies including patients with tuberous sclerosis complex." 08/01/1997 - "To study the pharmacokinetics of vigabatrin in a patient affected with tuberous sclerosis who developed major agitation and aggression, while receiving vigabatrin orally (1.5 g every 12 h) and in whom impaired renal function was diagnosed. "
5.	Partial Epilepsies (Epilepsy, Partial) 12/01/1993 - "Vigabatrin is most effective in drug-resistant partial epilepsy. " 12/01/1994 - "More specifically, vigabatrin, which is a very useful and well tolerated new antiepileptic drug for refractory partial epilepsy, should be started at a low dosage of 0.5 g/day with increments of 0.5 g/day every week. " 05/01/1999 - "These results suggest that vigabatrin may be an alternative first-line treatment for childhood partial epilepsies. " 01/01/2013 - "We included randomised, double-blind, placebo-controlled, fully published trials of vigabatrin in people with drug-resistant partial epilepsy. " 12/01/2010 - "Reports, published in full, of observational studies investigating the prevalence of visual field loss in patients with partial epilepsy treated with vigabatrin were included. "

Related Drugs and Biologics

1.	lamotrigine (Lamictal)
2.	Adrenocorticotropic Hormone (ACTH)
3.	gabapentin (Neurontin)
4.	Carbamazepine (Tegretol)
5.	gamma-Aminobutyric Acid (GABA)
6.	topiramate (Topamax)
7.	tiagabine (Gabitril)
8.	Anticonvulsants (Antiepileptic Drugs)
9.	felbamate (Felbatol)
10.	Valproic Acid (Valproate, Semisodium)

Related Therapies and Procedures

1.	Vagus Nerve Stimulation
2.	Relaxation Therapy
3.	Psychology Biofeedback (Biofeedback)
4.	Ketogenic Diet
5.	Intravenous Infusions