U7 Small Nuclear Ribonucleoprotein (U7 snRNP)

This ribonucleoprotein particle, composed of U7 snRNA, Sm core protein, and U7 snRNP-specific proteins, is involved in the 3'end processing of histone premessenger RNAs.

Also Known As:

U7 snRNP; Ribonucleoprotein, U7 Small Nuclear; Small Nuclear Ribonucleoproteins, U7; U7 Small Nuclear Ribonucleoproteins

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Small Nuclear Ribonucleoproteins: 266
        U7 Small Nuclear Ribonucleoprotein: 2
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Small Nuclear Ribonucleoproteins: 266
        U7 Small Nuclear Ribonucleoprotein: 2

Experts

1.	Link, J: 1 article (08/2000)
2.	Müller, B: 1 article (08/2000)
3.	Smythe, C: 1 article (08/2000)

Related Diseases

1.	Atrophy 01/01/2022 - "Co-expression of U7-specific Lsm10 and Lsm11 proteins selectively enhances U7 snRNP assembly, corrects histone mRNA processing defects, and rescues key structural and functional abnormalities of neuromuscular pathology in SMA mice-including NMJ denervation, decreased synaptic transmission, and skeletal muscle atrophy. "
2.	Type 1 Spherocytosis 08/11/2000 - "However, this does not depend on the U7 RNA being able to process histone RNA and also occurs with U1 snRNPs; therefore, association of SPH1 cannot be considered as a hallmark of a functional U7 snRNP."

Related Drugs and Biologics

1.	Histones (Histone)
2.	Messenger RNA (mRNA)
3.	RNA (Ribonucleic Acid)
4.	Proteins (Proteins, Gene)
5.	U7 small nuclear RNA (U7 snRNA)

Related Therapies and Procedures

1.	Denervation