Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)

An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.

Also Known As:

DAGO; DAMGE; DAMGO; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 2-Ala-4-MePhe-5-Gly-Enkephalin; Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; D-Ala2-NMe-Phe4-Gly-ol Enkephalin; DAGOL; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; RX-783006; Tyr-Ala-Gly-(NMe)Phe-Gly-ol; 2 Ala 4 MePhe 5 Gly Enkephalin; D Ala2 NMe Phe4 Gly ol Enkephalin; Enkephalin, D-Ala2-NMe-Phe4-Gly-ol; RX 783006; D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-nalpha-methyl-

Networked: 258 relevant articles (12 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        Enkephalins: 1042
        Ala(2)-MePhe(4)-Gly(5)- Enkephalin: 258
        Ala(2)-MePhe(4)-GlyNH2(5)- enkephalin
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - Enkephalins: 1042
        Ala(2)-MePhe(4)-Gly(5)- Enkephalin: 258
        Ala(2)-MePhe(4)-GlyNH2(5)- enkephalin

Experts

1.	Levine, Jon D: 5 articles (05/2018 - 03/2010)
2.	Baldo, Brian A: 4 articles (01/2022 - 03/2014)
3.	Bongianni, Fulvia: 4 articles (11/2021 - 07/2008)
4.	Cinelli, Elenia: 4 articles (11/2021 - 07/2008)
5.	Mutolo, Donatella: 4 articles (11/2021 - 07/2008)
6.	Pantaleo, Tito: 4 articles (11/2021 - 07/2008)
7.	Ferrari, Luiz F: 4 articles (05/2018 - 09/2015)
8.	Lasukova, T V: 4 articles (10/2015 - 08/2000)
9.	Capasso, Anna: 4 articles (03/2009 - 02/2002)
10.	Tavares, Isaura: 3 articles (01/2020 - 12/2008)

Related Diseases

1.	Hyperalgesia 01/01/2019 - "DAMGO induced anti-allodynia only after MOR-overexpression. " 01/01/2016 - "Combinations of DAMGO and ACPA also dose-dependently attenuated mechanical hyperalgesia, but the antihyperalgesic effects were partial and transient even at high doses. " 01/01/2016 - "When administered individually, DAMGO and ACPA dose-dependently reversed the mechanical hyperalgesia. " 01/01/2016 - "DAMGO (1μg-1mg) or ACPA (1μg-2mg) was administered into the inflamed paw when mechanical hyperalgesia was fully developed. " 01/01/2015 - "A 10-fold higher dose of DAMGO was required in female and GDX male rats to produce the level of anti- allodynia achieved in male rats. "
2.	Neuralgia (Stump Neuralgia) 09/01/2005 - "In both the spared nerve injury (SNI) and spinal nerve ligation (SNL) rat peripheral neuropathic pain models the presynaptic inhibitory effect of the mu opioid receptor (MOR) agonist (DAMGO) on primary afferent-evoked excitatory postsynaptic currents (EPSCs) and miniature EPSCs in superficial dorsal horn neurons is substantially reduced, but only in those spinal cord segments innervated by injured primary afferents. " 02/05/2021 - "In CCI model, DAMGO showed a general reduction in allodynia sensitivity for both nerve-injured and normal paws, without selective effect for neuropathic pain, consistent with clinical observation that opioids are less effective for chronic neuropathic pain. " 05/15/2000 - "DAMGO, a mu-opioid agonist, and DPDPE, a delta-opioid agonist, were highly effective in reducing neuropathic pain. " 02/19/1999 - "in comparison with Tyr-D-Ala-Gly-MePhe-Gly-ol (DAMGO) or morphine, during acute, inflammatory and neuropathic pain in rats chronically implanted with intrathecal cannulas. " 04/22/2004 - "Our study was designed to demonstrate peripheral antinociception of the mu-opioid receptor agonists: morphine (MF), [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]enkephalin (DAMGO), endomorphin-1 (EM-1) and endomorphin-2 (EM-2) in Bennett's rat model of neuropathic pain. "
3.	Hypersensitivity (Allergy) 02/01/2014 - "Peripherally administered DAMGO, a specific MOR agonist, significantly attenuated CFA-induced masseter mechanical hypersensitivity only in intact male rats. " 10/01/2022 - "Repeated intradermal injections of DAMGO resulted in mechanical hypersensitivity in rats, lasting more than 8 days. " 01/01/2017 - "DAMGO, a pure mu-opioid, was effective in reducing postoperative hypersensitivity in aged and adult mice, although adult mice displayed increased sensitivity to higher doses (50 μg local; 1–15 μg spinal). " 10/01/2022 - "However, intrathecal administration of dynorphin or an anti-dynorphin antibody (dynorphin antagonists) had no effect on DAMGO-induced hypersensitivity. " 02/01/2000 - "In contrast to hypersensitivity to U-50488H (1 and 10 microg, IT) noted in RCS-loaded mice, the antinociception induced by DAMGO (0.1 and 1 microg, ICV) was reduced compared to that of normal animals. "
4.	Ischemia 12/01/2014 - "DAMGO (1 μM) produced outward currents in ~60% of spinal lamina IX neurons at a holding potential of -70 mV. Superfusion with ischemia-simulating medium elicited an agonal current. " 08/01/2000 - "In vivo administration of DAMGO prevented reperfusion-induced damages to cardiomyocytes and decreased the content of conjugated dienes in the myocardium during ischemia-reperfusion in vitro. " 04/01/2001 - "The in vivo pretreatment with DAGO prevented reperfusion injury of cardiac cells and decreased myocardial content of conjugated dienes during ischemia and reperfusion of the heart in vitro. " 10/01/2015 - "Effects of μ-Opioid Receptor Agonist DAMGO on Heart Contractility and Necrotic Injury to Cardiomyocytes during Ischemia and Reperfusion of Isolated Rat Heart." 12/01/2014 - "The effects of the selective μ agonist [D-Ala(2),-N-Me-Phe(4), Gly(5)-ol]enkephalin (DAMGO) on ischemia-induced agonal currents were examined in the spinal lamina IX neurons of neonatal rats by using the whole-cell patch-clamp technique. "
5.	Pain (Aches) 06/17/2023 - "Moreover, compound 7, as potent as LP1 and DAMGO at MOR, was able to reduce thermal and inflammatory pain assessed by the mouse tail-flick test and rat paw pressure thresholds (PPTs) measured by a Randall-Selitto test." 12/01/2020 - "Repeated instillations of DAMGO also markedly reversed the elevated spontaneous activity of the ciliary nerve and responsiveness of corneal polymodal nociceptors that were observed in mice with corneal pain. " 01/01/2017 - "Spinal and systemic (intraperitoneal) DAMGO inhibited ongoing pain more in adults compared with aged mice. " 01/01/2017 - "Finally, exploratory locomotor activity was used to evaluate the suppression of incision-induced spontaneous pain by DAMGO. " 02/16/1988 - "Paralleling their effects on pain, DAGO and U50,488 elevated and reduced, respectively, lateral hypothalamic electrical stimulation threshold for positive reinforcement. "

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Morphine (MS Contin)
3.	mu Opioid Receptors (mu Opioid Receptor)
4.	Leucine-2-Alanine Enkephalin (Enkephalin, Leucine 2 Alanine)
5.	D-Penicillamine (2,5)- Enkephalin
6.	Enkephalins
7.	Opioid Receptors (Opioid Receptor)
8.	delta Opioid Receptors (delta Opioid Receptor)
9.	Thr(6)- Leu(5) Ser(2) enkephalin
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Injections
3.	Ligation
4.	Analgesia
5.	Intradermal Injections