Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)

An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
Also Known As:
DAGO; DAMGE; DAMGO; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 2-Ala-4-MePhe-5-Gly-Enkephalin; Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; D-Ala2-NMe-Phe4-Gly-ol Enkephalin; DAGOL; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; RX-783006; Tyr-Ala-Gly-(NMe)Phe-Gly-ol; 2 Ala 4 MePhe 5 Gly Enkephalin; D Ala2 NMe Phe4 Gly ol Enkephalin; Enkephalin, D-Ala2-NMe-Phe4-Gly-ol; RX 783006; D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-nalpha-methyl-
Networked: 216 relevant articles (9 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Lasukova, T V: 4 articles (10/2015 - 08/2000)
2. Capasso, Anna: 4 articles (03/2009 - 02/2002)
3. Maslov, L N: 3 articles (10/2015 - 02/2000)
4. McLaughlin, Patricia J: 3 articles (12/2007 - 04/2003)
5. Zagon, Ian S: 3 articles (12/2007 - 04/2003)
6. Tam, S V: 3 articles (09/2001 - 02/2000)
7. Levine, Jon D: 2 articles (09/2015 - 03/2010)
8. Kohno, Tatsuro: 2 articles (12/2014 - 09/2005)
9. Baldo, Brian A: 2 articles (12/2014 - 03/2014)
10. Brack, Alexander: 2 articles (07/2014 - 06/2012)

Related Diseases

1. Hyperalgesia
2. Ischemia
3. Pain (Aches)
4. Neuralgia (Stump Neuralgia)
05/15/2000 - "DAMGO, a mu-opioid agonist, and DPDPE, a delta-opioid agonist, were highly effective in reducing neuropathic pain. "
09/01/2005 - "In both the spared nerve injury (SNI) and spinal nerve ligation (SNL) rat peripheral neuropathic pain models the presynaptic inhibitory effect of the mu opioid receptor (MOR) agonist (DAMGO) on primary afferent-evoked excitatory postsynaptic currents (EPSCs) and miniature EPSCs in superficial dorsal horn neurons is substantially reduced, but only in those spinal cord segments innervated by injured primary afferents. "
02/19/1999 - "in comparison with Tyr-D-Ala-Gly-MePhe-Gly-ol (DAMGO) or morphine, during acute, inflammatory and neuropathic pain in rats chronically implanted with intrathecal cannulas. "
04/22/2004 - "Our study was designed to demonstrate peripheral antinociception of the mu-opioid receptor agonists: morphine (MF), [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]enkephalin (DAMGO), endomorphin-1 (EM-1) and endomorphin-2 (EM-2) in Bennett's rat model of neuropathic pain. "
02/09/2007 - "At 24 days after ethanol withdrawal, antinociception of morphine was significantly suppressed and the increased guanosine-5'-o-(3-thio) triphosphate ([(35)S]GTPgammaS) binding to membranes of the spinal cord induced by the selective mu-opioid receptor (MOR) agonist, [D-Ala(2),N-MePhe(4),Gly(5)-ol]enkephalin (DAMGO), was significantly decreased under the ethanol-dependent neuropathic pain-like state, whereas the increased [(35)S]GTPgammaS binding to membranes of the spinal cord induced by either the selective delta-opioid receptor (DOR) agonist or kappa-opioid receptor (KOR) agonist was not changed under the ethanol-dependent neuropathic pain-like state. "
5. AIDS-Related Complex (ARC)

Related Drugs and Biologics

1. Morphine (MS Contin)
2. mu Opioid Receptors (mu Opioid Receptor)
3. Leucine-2-Alanine Enkephalin (Enkephalin, Leucine 2 Alanine)
4. D-Penicillamine (2,5)- Enkephalin
5. Enkephalins
6. Opioid Receptors (Opioid Receptor)
7. delta Opioid Receptors (delta Opioid Receptor)
8. Thr(6)- Leu(5) Ser(2) enkephalin
9. Opioid Analgesics (Opioids)
10. Opioid Peptides (Opioid Peptide)

Related Therapies and Procedures

1. Intravenous Injections
2. Injections
3. Ligation
4. Analgesia
5. Intradermal Injections