HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Central Nervous System Cysts (Suprasellar Cyst)

Subscribe to New Research on Central Nervous System Cysts

Congenital or acquired cysts of the brain, spinal cord, or meninges which may remain stable in size or undergo progressive enlargement.

Also Known As:

Suprasellar Cyst; Rathke's Cleft Cysts; Cleft Cysts, Rathke's; Cyst, Suprasellar; Cysts, Rathke Cleft; Cysts, Suprasellar; Rathkes Cleft Cysts; Suprasellar Cysts; Cysts, Central Nervous System; Rathke Cleft Cysts

Networked: 55 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysts
2.	Craniopharyngioma (Craniopharyngiomas)
3.	Neoplasms (Cancer)
4.	Pituitary ACTH Hypersecretion
5.	Prolactinoma (Prolactinomas)

Experts

1.	Kelly, Daniel F: 4 articles (11/2013 - 02/2003)
2.	Jane, John A: 2 articles (10/2015 - 01/2008)
3.	Kim, J: 2 articles (10/2015 - 06/2002)
4.	Karavitaki, Niki: 2 articles (01/2014 - 02/2012)
5.	Ansorge, Olaf: 2 articles (01/2014 - 02/2012)
6.	Cohan, Pejman: 2 articles (11/2013 - 02/2003)
7.	Fahlbusch, Rudolf: 2 articles (12/2006 - 06/2005)
8.	Buslei, Rolf: 2 articles (12/2006 - 06/2005)
9.	Kreutzer, Jürgen: 2 articles (12/2006 - 06/2005)
10.	Thorner, Michael O: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Central Nervous System Cysts:

1.	Cerebrospinal fluid leakIBA 01/01/1998 - "This is a retrospective study of a series of 28 Rathke's cleft cysts operated on transsphenoidally that was undertaken for the following reasons: 1) to study the presentation, with particular reference to hormonal and visual disturbances; 2) to study postoperative improvements in endocrine function and vision; 3) to record postoperative complications; and 4) to assess the efficacy of a minor modification of the standard transsphenoidal surgical technique, whereby the cyst is allowed to drain directly into the sphenoid air sinus without fossa floor repair when there is no intraoperative cerebrospinal fluid leak. " 09/01/2010 - "The pathologies included 99 pituitary tumors, 15 craniopharyngiomas, 11 meningiomas, 11 Rathke's cleft cysts, 7 encephaloceles, 5 cerebrospinal fluid leak repairs, 9 clival chordomas, and 6 other pathologies of the sella. "
2.	ProlactinIBA 02/01/2003 - "At a median follow-up period of 16 months (range 3-45 months), surgical remission rates were as follows: in 40 patients with endocrine-inactive macroadenomas, 95% for noninvasive and 40% for invasive tumors; in the 20 patients with prolactinomas, 75% for prolactinomas with an initial prolactin (PRL) level lower than 200 ng/ml, 33% for those with a PRL level between 200 and 600 ng/ml, and 0% for those with a PRL level higher than 1400 ng/ml; in the 15 patients with Cushing disease, 73% for microadenomas and 25% for macroadenomas; in the 10 patients with acromegaly, 75% for microadenomas and 50% for macroadenomas; in the five patients with Rathke cleft cysts, 80%; and in the five patients with craniopharyngiomas, 40%. "
3.	Growth Hormone (Somatotropin)IBA 01/01/1995 - "Rathke's cleft cysts within a growth hormone producing pituitary adenoma." 05/01/2004 - "In childhood, the most common presenting symptoms of Rathke's cleft cysts are endocrine abnormalities, such as reduced growth hormone secretion, hyperprolactinemia, or diabetes insipidus. " 01/01/2010 - "The histological studies confirmed a case of sarcoidosis within a non-functioning pituitary adenoma, a case of intrasellar schwannoma coexisting with growth hormone (GH) secreting adenoma, two Rathke's cleft cysts combined with pituitary adenomas, three gangliocytomas associated with GH-secreting adenomas, and a case of a double pituitary adenoma. " 06/01/2013 - "Ten demonstrative cases of pituitary lesions, including three cases of gonadotropin-producing pituitary adenoma, two cases of somatotropin-secreting pituitary adenoma, and five cases of Rathke's cleft cysts, were entered in this study. " 09/01/2013 - "Non-functioning pituitary adenoma (NFPA) was the most common pathology (n = 152), followed by growth hormone secreting tumors (n = 41) and Rathke's cleft cysts (n = 30). "
4.	GonadotropinsIBA 06/01/2013 - "Ten demonstrative cases of pituitary lesions, including three cases of gonadotropin-producing pituitary adenoma, two cases of somatotropin-secreting pituitary adenoma, and five cases of Rathke's cleft cysts, were entered in this study. "
5.	beta CateninIBA 12/01/2006 - "Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft cysts: a clinico-pathologic approach." 06/01/2005 - "Furthermore, the expression pattern of beta-catenin was immunohistochemically analysed in a cohort of tumours and cysts of the sellar region including pituitary adenomas (n=58), craniopharyngiomas (n=57), arachnoidal cysts (n=8), Rathke's cleft cysts (n=10) and xanthogranulomas (n=6). "
6.	Gadolinium DTPA (Magnevist)FDA Link 03/01/1994 - "MR imaging with gadopentetate dimeglumine does assist in the diagnosis of Rathke cleft cysts. " 07/01/1994 - "We compared the position of the normal pituitary gland as estimated by gadolinium (Gd)-DTPA-enhanced MRI, with its position at surgery in 40 patients with intra- and juxtasellar tumours: 22 pituitary adenomas, 4 craniopharyngiomas, 7 meningiomas, 2 germinomas, and 5 Rathke cleft cysts. "
7.	SiliconesIBA 06/01/2002 - "Silicone plates were used in 10 patients who had 7 pituitary adenomas, 2 Rathke's cleft cysts, and 1 metastatic tumor. " 06/01/1998 - "A silicone plate was used to reconstruct the sellar floor in 69 consecutive patients with sellar tumors that included 60 pituitary adenomas and nine Rathke's cleft cysts. "
8.	MucinsIBA 05/01/1997 - "The lining cells and mucin of Rathke's cleft cysts also revealed CA19-9. " 07/01/1985 - "A tumor of Rathke's cleft origin was studied, which showed some histologic features consistent with craniopharyngioma, but also had ciliated and mucin-containing cells more commonly observed in Rathke's cleft cysts. "
9.	Keratins (Keratin)IBA 10/01/2002 - "Craniopharyngiomas had a cytokeratin expression pattern distinct from that of Rathke cleft cysts and pituitary gland pars intermedia: craniopharyngiomas did not express cytokeratins 8 and 20, whereas Rathke cleft cysts and pars intermedia of pituitary glands both expressed cytokeratins 8 and 20. " 11/01/2003 - "Chordoid glioma was immunoreactive for glial fibrillary acidic protein, S-100 protein and vimentin, and focally positive for epithelial membrane antigen and CD34, while cytokeratin highlighted epithelial cells lining Rathke's cleft cysts. "
10.	Colloids (Colloid)IBA 11/01/2009 - "Neurenteric cysts are lined by simple-to-pseudostratified respiratory/gastrointestinal-like epithelium; as such, these lesions closely resemble colloid and Rathke's cleft cysts. " 10/01/1993 - "This finding supports the neuroepithelial origin for choroid and ependymal cysts, and an endodermal nature for colloid and Rathke's cleft cysts. "

Therapies and Procedures

1.	Colonic Pouches (S Pouch) 10/01/2015 - "Rathke cleft cysts (RCCs) are benign embryonic remnants of the Rathke's pouch found in 13% to 33% of the general population. " 01/01/2015 - "Rathke's cleft cysts (RCC) are benign lesions that originate from remnants of Rathke's pouch. " 04/01/2014 - "Rathke's cleft cysts (RCC) are usually benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. " 01/01/2014 - "Rathke's cleft cysts are benign sellar and suprasellar lesions arising from epithelial remnants of Rathke's pouch with a peak incidence at 30-50 years of age. " 10/01/2013 - "Rathke's cleft cysts (RCC) are cystic sellar and suprasellar lesions derived from remnants of Rathke's pouch, lined by cuboidal or columnar epithelium. "
2.	Craniotomy 12/01/2013 - "The endonasal approach seems more appropriate for primarily intrasellar RCCs, while the craniotomy is recommended for purely or mainly suprasellar cysts. " 01/01/1989 - "By a right frontotemporal craniotomy, the suprasellar cyst was explored. " 04/01/1987 - "She had a right frontal craniotomy and a suprasellar cyst was subtotally removed. "
3.	Endoscopes 10/01/2005 - "Our data suggest that suprasellar cysts are well treated by endoscopic or endoscope-assisted procedures with good clinical outcome and low surgical morbidity." 10/01/2005 - "Between December 1996 and December 2003, 13 patients (7 female and 6 male patients), mean age 29 years, underwent endoscopic or endoscope-assisted procedures for suprasellar cysts at our department. "
4.	Sutures (Suture) 01/01/2015 - "In this paper, we present 8 consecutive cases involving arachnoid cysts and Rathke's cleft cysts, which were managed by using drainage and cisternostomy, the intentional fenestration of the cyst into the subarachnoid space, and then meticulously closing sellar floor using dural sutures. "
5.	Radiotherapy 01/01/1995 - "Rathke's cleft cysts only require limited surgical intervention, and radiotherapy is not necessary. "