Estrogen Receptor Modulators (Antiestrogen)

Substances that possess antiestrogenic actions but can also produce estrogenic effects as well. They act as complete or partial agonist or as antagonist. They can be either steroidal or nonsteroidal in structure.

Also Known As:

Networked: 2058 relevant articles (151 outcomes, 275 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Clarke, Robert: 21 articles (12/2015 - 06/2002)
2.	Lykkesfeldt, Anne E: 16 articles (01/2015 - 03/2003)
3.	Arteaga, Carlos L: 13 articles (01/2015 - 01/2003)
4.	Jordan, V Craig: 12 articles (12/2015 - 01/2002)
5.	Miller, Todd W: 11 articles (02/2014 - 05/2009)
6.	Riggins, Rebecca B: 10 articles (01/2015 - 06/2004)
7.	Sutherland, Robert L: 10 articles (07/2012 - 06/2002)
8.	Nicholson, Robert I: 9 articles (12/2014 - 01/2002)
9.	Nephew, Kenneth P: 9 articles (01/2012 - 10/2002)
10.	Jelovac, Danijela: 9 articles (05/2007 - 07/2002)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 05/01/1984 - "Since very useful non-steroidal antiestrogens have been synthesized recently, the usefulness of drug-based endocrine therapy for breast cancer has become more important compared with brought about by surgical therapy. " 02/01/2012 - "Antiestrogen therapy has been used successfully to prolong disease-free and overall survival of ER positive breast cancer patients. " 10/15/2010 - "These observations suggest 1 mechanism whereby AIs, which block E(2) synthesis, would be more effective for breast cancer prevention than use of antiestrogens, which only block ER-mediated effects." 12/01/2013 - "Taken together, our findings identify SHON as a novel human oncogene with predictive utility in ER(+) breast cancer, perhaps offering a simple biomarker to predict the therapeutic efficacy of antiestrogen therapy in patients with breast cancer." 01/01/2011 - "Consistent support for the hypothesis that antiestrogens are effective in reducing contralateral breast cancer risks is available from the literature. "
2.	Neoplasms (Cancer) 10/01/2011 - "This novel treatment strategy may be most effective in women with antiestrogen insensitive tumors, a patient population with historically poor response to traditional therapies." 12/01/1977 - "Our data suggest that canine mammary tumors with significant ER levels would respond favorably to antiestrogen therapy. " 06/01/2003 - "The results suggest that in ER+ tumors, FR-alpha expression is directly and actively suppressed and predict that a brief treatment with antiestrogens will boost FR-alpha expression by passive derepression, enhancing the efficacy of FR-targeted diagnostic and therapeutic applications. " 07/01/1998 - "Both antiestrogens were effective in reducing tumor growth in these mice. " 02/01/1985 - "Both antiestrogens were effective in delaying the development of secondary tumors, especially during the time of treatment. "
3.	Carcinoma (Carcinomatosis) 12/01/2001 - "Based on this and another case reported in the literature, we believe that antiestrogen therapy could prove beneficial in a subset of patients with sweat gland carcinoma. " 01/01/2004 - "The aim of this study was to determine whether Z-(123)I-MIVE scintigraphy is able to predict response or resistance to antiestrogen therapy in patients with metastatic ER-positive breast carcinoma. " 03/01/1987 - "This study attempts to investigate the in vitro effects of E and antiestrogen (AE) on promoting cell proliferation and the cell cycle kinetics of an experimental mammary carcinoma model, CAMA-1. " 06/28/2013 - "This DDS was designed to deliver miproxifen phosphate (TAT-59), an antiestrogen drug, to ductal lesions via the milk duct, where carcinomas originate, more efficiently than systemic administration, using an iontophoretic technique applied to the nipple (IP administration). " 02/15/2011 - "At the human equivalent molar dose of TAM (0.33 or 1.0 mg/kg), SS5020 had much stronger antitumor potential than those same antiestrogens against 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats. "
4.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2004 - "However, response to antiestrogen drugs in BRCA1-blocked ER-positive ovarian cancer cells has not been reported, and this served as the rationale for this study. " 12/01/1987 - "These results indicated that ovarian cancer containing ER, even though it originated from germ cells, would be responsible for antiestrogen therapy." 07/01/2001 - "The finding of a lower apoptotic activity in tumors with a high expression of ER and an indication of increased proliferation in areas with high ER density gives a rationale for antiestrogen therapy even in poorly differentiated epithelial ovarian cancers. " 01/01/2013 - "Estrogen exposure has at least a moderate effect on the risk for ovarian cancer, and antiestrogen therapy may be helpful in treating the disease. " 09/16/2013 - "Data on the efficacy and safety of antiestrogens and aromatase inhibitors in recurrent ovarian cancer have been accumulated through phase II clinical studies. "
5.	Neoplasm Metastasis (Metastasis) 06/28/2007 - "Estimated and true 5-10 year overall survival rates from first line antiestrogen and distant metastases were higher than previously reported in a similar population. " 01/01/2003 - "The patient received antiestrogen therapy but subsequently developed skeletal metastases. " 02/01/2006 - "Ninety-seven postmenopausal patients with axillary lymph node metastasis were treated with an antiestrogen for a period of 3 years after primary surgery and radiotherapy. " 03/01/2014 - "Our results indicate that targeting the GPR30 signaling may be a potential strategy to reduce metastasis and improve the efficacy of antiestrogens in treatment of advanced breast cancer. " 09/01/2007 - "In sum, loss of p27 activated AIB1, E2F1, Gab2, and Akt; increased cell migration and invasion; caused antiestrogen insensitivity; and promoted metastasis of breast cancer cells. "

Related Drugs and Biologics

1.	Tamoxifen
2.	Estrogens (Estrogen)
3.	Hormones
4.	Aromatase Inhibitors
5.	Aromatase (CYP19)
6.	fulvestrant (Faslodex)
7.	Toremifene (Fareston)
8.	Progesterone Receptors (Progesterone Receptor)
9.	Estradiol (Estrace)
10.	letrozole (Femara)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Chemoprevention
3.	Heterologous Transplantation (Xenotransplantation)
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)