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Tissue Kallikreins (Tissue Kallikrein)

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A family of trypsin-like SERINE ENDOPEPTIDASES that are expressed in a variety of cell types including human prostate epithelial cells. They are formed from tissue prokallikrein by action with TRYPSIN. They are highly similar to PROSTATE-SPECIFIC ANTIGEN. EC 3.4.21.35.

Also Known As:

Tissue Kallikrein; Kallikrein, Prostate Specific; Glandular Kallikrein; Glandular Kallikrein-1; Kallikrein 1; Kallikrein 2; Prostate Specific Kallikrein; 1, Kallikrein; 2, Kallikrein; Glandular Kallikrein 1; Glandular Kallikreins, Human; Kallikrein, Glandular; Kallikrein, Pancreatic; Kallikrein, Tissue; Kallikrein, Urinary; Kallikrein, hK1; Kallikrein, hK2; Kallikrein-1, Glandular; Kallikreins, Human Glandular; Kallikreins, Tissue; Specific Kallikrein, Prostate; Human Glandular Kallikrein 1; Human Glandular Kallikrein 2; Human Glandular Kallikreins; Pancreatic Kallikrein; Urinary Kallikrein; hK1 Kallikrein; hK2 Kallikrein

Networked: 672 relevant articles (26 outcomes, 73 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Diamandis, Eleftherios P: 34 articles (09/2014 - 05/2002)
2.	Chao, Julie: 30 articles (09/2014 - 03/2002)
3.	Chao, Lee: 29 articles (09/2014 - 03/2002)
4.	Lilja, Hans: 18 articles (01/2015 - 08/2002)
5.	Diamandis, E P: 13 articles (08/2011 - 01/2000)
6.	Scorilas, Andreas: 12 articles (09/2014 - 05/2002)
7.	Shen, Bo: 11 articles (01/2013 - 05/2006)
8.	Yousef, George M: 10 articles (04/2015 - 05/2002)
9.	Yin, Hang: 10 articles (01/2013 - 03/2005)
10.	Bledsoe, Grant: 9 articles (09/2014 - 08/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 03/01/2013 - "Tissue kallikrein has been suggested to be involved in blood pressure regulation and in protection against hypertension. " 07/01/2008 - "Our study indicates that rAAV-mediated human tissue kallikrein gene delivery is a potentially safe method for the long-term treatment of hypertension. " 09/01/2007 - "The aim of this study was to investigate the association between common variants in the human tissue kallikrein 1 (KLK1) gene and susceptibility to essential hypertension in Chinese Han. " 09/01/2007 - "A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-based association study in a Chinese Han population." 09/01/2005 - "This present study aimed to study the polymorphisms of the regulatory region of human tissue kallikrein gene of the Chinese and investigate the relationship of the polymorphisms with essential hypertension. "
2.	Prostatic Neoplasms (Prostate Cancer) 09/01/2003 - "Clinical measurement of human glandular kallikrein 2 (hK2) serves as a complementary marker to PSA for early detection of prostate cancer and constitutes a considerable improvement over PSA as a staging marker for clinically localized prostate cancer. " 04/01/2003 - "Measurement of human kallikrein 2 (hK2) has improved early detection and staging of prostate cancer. " 09/01/2005 - "In this study, we now show that the comparative expression of hK4 protein in prostate cancer tissues, compared with benign glands, is greater than that of PSA and kallikrein 2 (KLK2/hK2), suggesting that hK4 may play an important functional role in prostate cancer progression in addition to its biomarker potential. " 02/15/2003 - "In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (PCa). " 02/01/2003 - "We analyzed and systematized data from studies regarding the effectiveness of PSA and human glandular kallikrein 2 and their derivatives in the detection of prostate cancer. "
3.	Myocardial Infarction 10/01/2008 - "One day after myocardial infarction, tissue kallikrein treatment significantly improved cardiac contractility and reduced myocardial infarct size and left ventricle end diastolic pressure in Brown Norway Katholiek rats. " 01/01/2013 - "Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction." 08/01/2012 - "Tissue kallikrein (TK) has been demonstrated to improve neovasculogenesis after myocardial infarction (MI). " 04/01/2008 - "Tissue kallikrein deficiency aggravates cardiac remodelling and decreases survival after myocardial infarction in mice." 02/01/2008 - "New perspective on the tissue kallikrein-kinin system in myocardial infarction: role of angiogenesis and cardiac regeneration."
4.	Inflammation 08/01/1994 - "Inhibitors of tissue kallikrein may prove effective in the treatment of allergic inflammation in man." 04/01/2005 - "The further observation of an increased tissue kallikrein activity at the systemic and saliva levels may be interpreted as a systemic reflex of skin inflammation. " 07/01/2000 - "The pharmacological activity of phenylacetyl-Phe-Ser-Arg-N-(2, 4-dinitrophenyl)-ethylenediamine (TKI), a tissue kallikrein specific inhibitor, was assessed using models of nociception and inflammation in mice. " 08/01/1994 - "Synthetic inhibitors of tissue kallikrein: effects in vivo in a model of allergic inflammation." 01/01/1989 - "Specimens of the gastric mucosa were obtained by biopsy to measure tissue kallikrein as a marker of inflammation. "
5.	Ischemia 04/01/2004 - "Prophylactic gene therapy with human tissue kallikrein ameliorates limb ischemia recovery in type 1 diabetic mice." 03/04/2005 - "Our previous study has shown that human tissue kallikrein protected against ischemia/reperfusion-induced myocardial injury. " 04/01/2004 - "The present study investigated whether prophylactic gene therapy with human tissue kallikrein (hTK) may protect diabetic limbs from the consequences of supervening ischemia. " 05/01/2009 - "Here, we demonstrate that tissue kallikrein knockout mice (KLK1-/-) show impaired muscle neovascularization in response to hindlimb ischemia. " 06/01/2008 - "Tissue kallikrein and kinin infusion promotes neovascularization in limb ischemia."

Related Drugs and Biologics

1.	Kallikreins (Kallikrein)
2.	Renin
3.	Aldosterone
4.	Potassium
5.	Prostate-Specific Antigen (Semenogelase)
6.	Sodium
7.	Kininogens (Kininogen)
8.	Biological Markers (Surrogate Marker)
9.	Messenger RNA (mRNA)
10.	Antigens

Related Therapies and Procedures

1.	Stents
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Nephrectomy
4.	Kidney Transplantation
5.	Surgical Instruments (Clip)