HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Pseudobulbar Palsy

Subscribe to New Research on Pseudobulbar Palsy

A syndrome characterized by DYSARTHRIA, dysphagia, dysphonia, impairment of voluntary movements of tongue and facial muscles, and emotional lability. This condition is caused by diseases that affect the motor fibers that travel from the cerebral cortex to the lower BRAIN STEM (i.e., corticobulbar tracts); including MULTIPLE SCLEROSIS; MOTOR NEURON DISEASE; and CEREBROVASCULAR DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p489)

Also Known As:

Pseudobulbar Mutism; Pseudobulbar Paralysis; Pseudobulbar Paresis; Pseudobulbar Syndrome; Bulbar Palsies, Spastic; Bulbar Palsy, Spastic; Dysarthrias, Pseudobulbar; Mutism, Pseudobulbar; Mutisms, Pseudobulbar; Palsies, Pseudobulbar; Palsies, Spastic Bulbar; Palsy, Pseudobulbar; Palsy, Spastic Bulbar; Paralyses, Pseudobulbar; Pareses, Pseudobulbar; Paresis, Pseudobulbar; Pseudobulbar Dysarthria; Pseudobulbar Dysarthrias; Pseudobulbar Mutisms; Pseudobulbar Palsies; Pseudobulbar Paralyses; Pseudobulbar Pareses; Pseudobulbar Syndromes; Spastic Bulbar Palsies; Syndrome, Pseudobulbar; Syndromes, Pseudobulbar; Dysarthria, Pseudobulbar; Paralysis, Pseudobulbar; Spastic Bulbar Palsy

Networked: 48 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dementia (Dementias)
2.	Paralysis (Palsy)
3.	Parkinsonian Disorders (Parkinsonism)
4.	Epilepsy (Aura)
5.	Malformations of Cortical Development

Experts

1.	Pollak, Pierre: 1 article (06/2015)
2.	Horvath, Judit: 1 article (06/2015)
3.	Ghika, Joseph: 1 article (06/2015)
4.	Nicastro, Nicolas: 1 article (06/2015)
5.	Cheon, Miju: 1 article (02/2015)
6.	Lee, Kyung-Han: 1 article (02/2015)
7.	Yasuda, Clarissa L: 1 article (07/2014)
8.	Costa, André L F: 1 article (07/2014)
9.	Teixeira, Karine C: 1 article (07/2014)
10.	Guimarães, Catarina A: 1 article (07/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pseudobulbar Palsy:

1.	Levodopa (L Dopa)FDA LinkGeneric 07/20/2002 - "In patients with vascular PS (VP) there is generally no tremor and rigidity, but pseudobulbar palsy, dementia, gate disturbance, incontinency appears; L-dopa treatment is generally ineffective. " 06/01/1996 - "RESULTS--The most frequent clinical features (occurring in at least 75% of the patients) were early postural instability and falls, vertical supranuclear palsy, akinetic-rigid predominant parkinsonian disorder characterised by symmetric bradykinesia and axial rigidity unrelieved by levodopa, pseudobulbar palsy, and frontal release signs. " 01/01/1996 - "The following items, present in at least 80% of pathologically confirmed cases, can be considered as the most accurate clinical data for the diagnosis of PSP: non-familial parkinsonism, not improved by L-dopa therapy, with vertical voluntary gaze palsy; postural instability and falls; pseudobulbar palsy and dementia with frontal lobe-like syndrome; and a progressive course of less than 10 years. " 10/01/1994 - "Furthermore, additional administration of L-dopa and droxidopa improved his pseudobulbar palsy, akinesia, and lack of initiative. "
2.	DroxidopaIBA 10/01/1994 - "Furthermore, additional administration of L-dopa and droxidopa improved his pseudobulbar palsy, akinesia, and lack of initiative. "
3.	Perisylvian syndromeIBA 11/01/2004 - "Congenital bilateral perisylvian syndrome (CBPS) is a congenital neurological syndrome characterized by pseudobulbar palsy, cognitive deficits and bilateral perisylvian abnormalities observed on imaging. " 07/01/2001 - "The main features of congenital bilateral perisylvian syndrome (CBPS) are pseudobulbar palsy, cognitive deficits, epilepsy, and perisylvian abnormalities on imaging studies, however, the clinical spectrum of this syndrome is much wider than previously believed and may vary from minor speech difficulties to severely disabled patients. " 01/01/2014 - "Congenital bilateral perisylvian syndrome (CBPS) is characterized by epilepsy, cognitive deficits, pseudobulbar palsy and diplegia of the facial, pharyngeal and masticatory muscles. " 07/13/1998 - "The congenital bilateral perisylvian syndrome is characterized by pseudobulbar palsy, moderate delay in mental and motor development and epilepsy. " 08/01/1994 - "Congenital bilateral perisylvian syndrome(CBPS) is a recently described disease identify characterized by pseudobulbar palsy, epilepsy, mental retardation, and migration disorders in the bilateral perisylvian area. "
4.	Complement Factor D (Factor D)IBA 10/01/2011 - "Orthogonal design was used to study the different combinations of treatment programs among four factors and three levels, named acupuncture opportunity (factor A: A1: 1-10 d, A2: 11-20 d, A3: 21-40 d), point combination (factor B: B1: points in the neck, B2: points in the neck + points in the glossopharyngeal part, B3: points in the neck + points in the glossopharyngeal part + differentiating point), needling depth (factor C: C1: shallow puncture, C2: moderate puncture, C3: deep puncture), and treatment session (factor D: D1: 2 sessions, D2: 4 sessions, D3: 6 sessions); as well as the influences on pseudobulbar palsy dysphagia after cerebral infarction so as to determine primarily the optimized acupuncture program for dysphagia after cerebral infarction. "
5.	Complement Factor B (Factor B)IBA 10/01/2011 - "Orthogonal design was used to study the different combinations of treatment programs among four factors and three levels, named acupuncture opportunity (factor A: A1: 1-10 d, A2: 11-20 d, A3: 21-40 d), point combination (factor B: B1: points in the neck, B2: points in the neck + points in the glossopharyngeal part, B3: points in the neck + points in the glossopharyngeal part + differentiating point), needling depth (factor C: C1: shallow puncture, C2: moderate puncture, C3: deep puncture), and treatment session (factor D: D1: 2 sessions, D2: 4 sessions, D3: 6 sessions); as well as the influences on pseudobulbar palsy dysphagia after cerebral infarction so as to determine primarily the optimized acupuncture program for dysphagia after cerebral infarction. "
6.	factor AIBA 10/01/2011 - "Orthogonal design was used to study the different combinations of treatment programs among four factors and three levels, named acupuncture opportunity (factor A: A1: 1-10 d, A2: 11-20 d, A3: 21-40 d), point combination (factor B: B1: points in the neck, B2: points in the neck + points in the glossopharyngeal part, B3: points in the neck + points in the glossopharyngeal part + differentiating point), needling depth (factor C: C1: shallow puncture, C2: moderate puncture, C3: deep puncture), and treatment session (factor D: D1: 2 sessions, D2: 4 sessions, D3: 6 sessions); as well as the influences on pseudobulbar palsy dysphagia after cerebral infarction so as to determine primarily the optimized acupuncture program for dysphagia after cerebral infarction. "
7.	factor CIBA 10/01/2011 - "Orthogonal design was used to study the different combinations of treatment programs among four factors and three levels, named acupuncture opportunity (factor A: A1: 1-10 d, A2: 11-20 d, A3: 21-40 d), point combination (factor B: B1: points in the neck, B2: points in the neck + points in the glossopharyngeal part, B3: points in the neck + points in the glossopharyngeal part + differentiating point), needling depth (factor C: C1: shallow puncture, C2: moderate puncture, C3: deep puncture), and treatment session (factor D: D1: 2 sessions, D2: 4 sessions, D3: 6 sessions); as well as the influences on pseudobulbar palsy dysphagia after cerebral infarction so as to determine primarily the optimized acupuncture program for dysphagia after cerebral infarction. "
8.	Foix Chavany Marie syndromeIBA 12/01/2009 - "Foix-Chavany-Marie Syndrome (FCMS) or bilateral opercular syndrome is characterised by faciopharyngoglossomasticatory diplegia with automatic voluntary dissociation and is a rare form of pseudobulbar palsy most commonly associated with occlusive cerebrovascular disease. " 02/01/2000 - "Foix-Chavany-Marie syndrome (FCMS) is a distinct clinical picture of suprabulbar (pseudobulbar) palsy due to bilateral anterior opercular lesions. " 09/01/1995 - "Foix-Chavany-Marie Syndrome or anterior opercular syndrome constitutes the cortical form of pseudobulbar palsy. " 07/01/1992 - "Acquired bilateral anterior opercular lesions result in the characteristic Foix-Chavany-Marie syndrome that features expressive dysphasia and pseudobulbar palsy. "
9.	Worster Drought syndromeIBA 01/01/2008 - "Worster-Drought syndrome (WDS) is a distinct clinical phenotype, comprising a congenital pseudobulbar palsy usually in association with a mild tetraplegia and often additional impairments. " 10/01/2007 - "Worster-Drought syndrome (WDS) is a developmental disorder presenting as mild tetraplegic cerebral palsy (CP) with severe pseudobulbar palsy, manifested as articulation problems or anarthria, chewing, and swallowing difficulties and severe drooling. " 06/03/2008 - "Worster-Drought syndrome (WDS) (congenital bilateral perisylvian syndrome, congenital pseudobulbar paresia) is characterized by neuronal migration defect, pseudobulbar paralysis, epilepsy, neuromotor retardation and perisylvian dysplasia. " 04/01/2006 - "Worster-Drought syndrome (WDS) (congenital bilateral perisylvian syndrome, congenital pseudobulbar paresia) is characterized by neuronal migration defect, pseudobulbar paralysis, epilepsy, neuromotor retardation and perisylvian dysplasia. "
10.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 07/01/2010 - "Regulating the Governor Vessel and Conception Vessel has a significant therapeutic effect for treatment of pseudobulbar palsy after stroke, and superior to that of routine needling." 07/01/2010 - "[Regulating the governor Vessel and Conception Vessel for treatment of pseudobulbar palsy after stroke]." 05/01/1994 - "Parkinsonism with prominent gait disturbances in conjunction with pyramidal tract signs, dysarthria, pseudobulbar affect, and incontinence are frequent motor manifestations of VAD with small vessel disease. "

Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation) 01/01/2003 - "The clinical picture evolved to a reversible pseudobulbar palsy requiring mechanical ventilation. " 09/01/1997 - "A 53-year-old woman developed bulbar palsy, spastic quadriplegia, amyotrophy, and supranuclear ophthalmoplegia, and thereafter her condition was managed with mechanical ventilation for 1 year. "
2.	Drug Therapy (Chemotherapy) 02/01/2003 - "Appropriate indications for PEG placement are 1) Esophageal obstruction (e.g., esophageal cancer), 2) Neurologic etiology of dysphagia without obstruction (e.g., status post cerebrovascular accident, pseudobulbar palsy), 3) Prolonged refusal to swallow without evidence of concomitant terminal illness (e.g., protracted pseudodementia due to severe depression), 4) Supplemental nutrition for patients undergoing chemotherapy or radiation therapy. " 01/01/1980 - "The syndrome usually began several months after the initiation of chemotherapy with subtle personality changes followed by a progressive dementia, focal seizures, pseudobulbar palsy, spastic quadriparesis, and stupor. "
3.	Deep Brain Stimulation 06/01/2015 - "Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei."
4.	Surgical Decompression 09/01/1999 - "Three to 18 months after surgical decompression of the thoracic arachnoid cyst, the patient developed a diffuse predominantly upper motor neuron syndrome characterized by spastic quadriparesis, pseudobulbar paresis, and pseudobulbar affect. "
5.	Carotid Endarterectomy 09/01/1985 - "Pseudobulbar palsy after carotid endarterectomy."