ADP-Ribosylation Factor 1

ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the interaction of coat proteins with organelle membranes in the early secretory pathway. It is a component of COAT PROTEIN COMPLEX I. This enzyme was formerly listed as EC 3.6.1.47.

Also Known As:

Networked: 32 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Claing, Audrey: 4 articles (03/2016 - 12/2008)
2.	Teng, Yong: 3 articles (01/2020 - 09/2016)
3.	Schlienger, Sabrina: 3 articles (03/2016 - 01/2014)
4.	He, Leilei: 2 articles (01/2020 - 02/2019)
5.	Randazzo, Paul A: 2 articles (12/2019 - 11/2008)
6.	Campbell, Shirley: 2 articles (03/2016 - 01/2014)
7.	Li, XiangRui: 1 article (07/2022)
8.	Muhammad, Ali Memon: 1 article (07/2022)
9.	Muhammad, Haseeb: 1 article (07/2022)
10.	Muhammad, Tahir Aleem: 1 article (07/2022)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2017 - "ADP-ribosylation factor 1 (ARF1) is a small G protein that regulates many cellular processes such as reorganization of the actin cytoskeleton and is highly expressed in various tumor cells and tissues. " 01/01/2017 - "CNK1 clusters induced by activating Ser22 mutants correlate with enhanced cell invasion and binding to and activation of ADP ribosylation factor 1 associated with tumor formation. " 06/01/2005 - "[Expression and significance of ADP-ribosylation factor 1 (ARF1) in colorectal laterally spreading tumor]." 01/01/2021 - "PLB promoted ROS production, activated the endoplasmic reticulum (ER) stress pathway, and induced cell apoptosis, accompanied by the decreased expression level of ADP-ribosylation factor 1 (ARF1) in NSCLC cancer cells, and those effects of PLB could be reversed by the pretreatment with N-acetyl-L-cysteine (NAC). " 12/01/2019 - "Here, we focus on the ADP-ribosylation factor 1 (Arf1), which interacts with numerous proteins in the Arf pathway, such as the ArfGAP ASAP1 that is highly expressed and activated in several cancer cell lines and associated with enhanced migration, invasiveness, and poor prognosis. "
2.	Neoplasm Metastasis (Metastasis) 09/06/2016 - "Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1." 01/01/2023 - "We identified ARF1 (ADP-ribosylation factor 1) as a novel regulator of both vemurafenib resistance and cancer metastasis, its molecular mechanism and potential inhibitor were investigated in this study. "
3.	Breast Neoplasms (Breast Cancer) 09/06/2016 - "Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1." 09/06/2016 - "We report for the first time that ADP-ribosylation factor 1 (ARF1) is the most amplified gene in ARF gene family in breast cancer, and high-level amplification of ARF1 is associated with increased mRNA expression and poor outcomes of patients with breast cancer. " 01/01/2015 - "We have previously reported that the small GTPase ADP-Ribosylation Factor 1 (ARF1) is highly expressed in invasive breast cancer cells and acts as a molecular switch to activate EGF-mediated responses. " 12/26/2008 - "Using an invasive breast cancer cell lines, we demonstrate that the ADP-ribosylation factor 1 (ARF1), a small GTPase classically associated with the Golgi, is an important regulator of the biological effects induced by epidermal growth factor. " 12/26/2008 - "ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells."
4.	Infections 01/01/2020 - "We have identified cellular factors that are critical in the induction of the VS. We show that ADP-ribosylation factor 1 (ARF1), bridging integrator 1 (BIN1), and Rab GTPases RAB7L1 and RAB8A are important regulators of HIV-1 trafficking to the VS and therefore the infection of CD4+ T cells. " 01/01/2010 - "Finally, overexpression of ADP-ribosylation factor 1 (Arf1), a small GTPase essential for the maintenance of the Golgi apparatus, restored Golgi morphology during infection. " 11/01/2007 - "Instead, PLD activity rapidly decreased upon infection and upon ectopic expression of the viral 3A protein, which inhibits the PLD activator ADP-ribosylation factor 1. However, similar decreases were observed during infection with coxsackieviruses carrying defective mutant 3A proteins. " 05/01/2002 - "Infection is strongly inhibited by expression of GTP-restricted ADP-ribosylation factor 1 (Arf1) and Sar1 mutants and by microinjection of antibodies to betaCOP. "
5.	Triple Negative Breast Neoplasms 03/29/2016 - "ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer." 01/01/2015 - "The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors."

Related Drugs and Biologics

1.	Vemurafenib
2.	Proteins (Proteins, Gene)
3.	Monomeric GTP-Binding Proteins
4.	GTP Phosphohydrolases (GTPases)
5.	Messenger RNA (mRNA)
6.	Epidermal Growth Factor (EGF)
7.	ErbB Receptors (EGF Receptor)
8.	Guanosine Triphosphate (GTP)
9.	Peroxiredoxin III
10.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)

Related Therapies and Procedures

1.	Therapeutics