Escherichia coli Meningitis

A form of gram-negative meningitis that tends to occur in neonates, in association with anatomical abnormalities (which feature communication between the meninges and cutaneous structures) or as OPPORTUNISTIC INFECTIONS in association with IMMUNOLOGIC DEFICIENCY SYNDROMES. In premature neonates the clinical presentation may be limited to ANOREXIA; VOMITING; lethargy; or respiratory distress. Full-term infants may have as additional features FEVER; SEIZURES; and bulging of the anterior fontanelle. (From Menkes, Textbook of Child Neurology, 5th ed, pp398-400)

Also Known As:

Networked: 58 relevant articles (8 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Meningitis
2.	Brain Injuries (Brain Injury)
3.	Inflammation
4.	Infection
5.	Brain Edema (Cerebral Edema)

Experts

1.	Park, W S: 5 articles (12/2001 - 02/2000)
2.	Chang, Y S: 5 articles (12/2001 - 02/2000)
3.	Lee, M: 5 articles (12/2001 - 02/2000)
4.	Nau, Roland: 4 articles (12/2007 - 06/2003)
5.	Gerber, Joachim: 4 articles (12/2007 - 06/2003)
6.	Bidet, Philippe: 3 articles (04/2014 - 12/2007)
7.	Bonacorsi, Stéphane: 3 articles (04/2014 - 12/2007)
8.	Spreer, Annette: 3 articles (12/2007 - 08/2006)
9.	Hanssen, Mareike: 3 articles (12/2007 - 08/2006)
10.	Bingen, Edouard: 2 articles (07/2012 - 12/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Escherichia coli Meningitis:

1.	Cefotaxime (Kendrick)FDA LinkGeneric 03/01/1986 - "In addition, two cases of Escherichia coli meningitis in which moxalactam therapy inexplicably failed were cured with cefotaxime. " 01/01/1985 - "In addition, two cases of Escherichia coli meningitis which had inexplicably failed on moxalactam were cured with cefotaxime. " 09/01/1982 - "Penetration of cefotaxime and moxalactam into cerebrospinal fluid of rabbits with experimentally induced Escherichia coli meningitis." 09/01/1987 - "We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. " 03/01/1986 - "The therapeutic efficacy of the fluoroquinolone pefloxacin mesylate was compared with those of cefotaxime and chloramphenicol in a rabbit model of Escherichia coli meningitis. "
2.	Moxalactam (Latamoxef)FDA Link 01/01/1982 - "Relapse of Escherichia coli meningitis following therapy with moxalactam." 01/01/1981 - "Moxalactam in treatment of recurrent Escherichia coli meningitis and ventriculitis in an infant with agammaglobulinemia." 03/01/1986 - "In addition, two cases of Escherichia coli meningitis in which moxalactam therapy inexplicably failed were cured with cefotaxime. " 01/01/1985 - "In addition, two cases of Escherichia coli meningitis which had inexplicably failed on moxalactam were cured with cefotaxime. " 09/01/1982 - "Penetration of cefotaxime and moxalactam into cerebrospinal fluid of rabbits with experimentally induced Escherichia coli meningitis."
3.	Chloramphenicol (Chloromycetin)FDA Link 09/01/1987 - "We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. " 04/01/1985 - "In a case of neonatal Escherichia coli meningitis good serum levels of chloramphenicol were achieved with chloramphenicol palmitate orally, supporting the view that oral chloramphenicol palmitate can be used to treat serious infections in this age group. " 03/01/1986 - "The therapeutic efficacy of the fluoroquinolone pefloxacin mesylate was compared with those of cefotaxime and chloramphenicol in a rabbit model of Escherichia coli meningitis. " 01/01/1980 - "The activities of cefamandole, cephalothin, ampicillin, and chloramphenicol were compared in fulminant and temperate Escherichia coli meningitis in rabbits. " 01/01/1980 - "Comparison of cefamandole, cephalothin, ampicillin, and chloramphenicol in experimental Escherichia coli meningitis."
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/1999 - "Efficacy of anti-tumor necrosis factor-alpha antibody as an adjunctive therapy in experimental Escherichia coli meningitis in the newborn piglet." 08/01/2011 - "Stimulation panels included Toll-Like receptor (TLR) ligands; the inflammation mediator tumor necrosis factor-α; and the pathogens cytomegalovirus, Neisseria meningitides, Escherichia coli, and Streptococcus pneumoniae. " 09/01/1993 - "In a rabbit Escherichia coli meningitis model, endotoxin liberation and concentrations of leukocytes, tumor necrosis factor (TNF), and lactate were compared after a single intravenous dose of cefotaxime, cefpirome, meropenem, chloramphenicol, or gentamicin. "
5.	Streptomycin (Streptomycin Sulfate)FDA Link 01/01/1950 - "Escherichia coli meningitis treated successfully with streptomycin." 10/15/1947 - "Escherichia coli meningitis treated with streptomycin."
6.	PefloxacinIBA 03/01/1986 - "Evaluation of pefloxacin in experimental Escherichia coli meningitis." 03/01/1986 - "The therapeutic efficacy of the fluoroquinolone pefloxacin mesylate was compared with those of cefotaxime and chloramphenicol in a rabbit model of Escherichia coli meningitis. "
7.	Pentoxifylline (Trental)FDA LinkGeneric 05/01/2000 - "The efficacy of pentoxifylline as an anti-inflammatory agent in experimental Escherichia coli meningitis in the newborn piglet."
8.	gatifloxacin (Zymar)FDA Link 07/01/1999 - "Efficacy of gatifloxacin in experimental Escherichia coli meningitis."
9.	thienamycinIBA 03/01/1982 - "Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis."
10.	Amino AcidsFDA Link 08/01/1993 - "Effect of experimental Escherichia coli meningitis on concentrations of excitatory and inhibitory amino acids in the rabbit brain: in vivo microdialysis study."

Therapies and Procedures

1.	Catheters 09/01/1995 - "Escherichia coli meningitis and septicemia associated with an epidural catheter."
2.	Neurosurgical Procedures 09/01/1990 - "This is a report of fungal pseudomeningitis superimposed on a case of nosocomial Escherichia coli meningitis resulting from a neurosurgical procedure. "
3.	Ventriculoperitoneal Shunt 11/01/1999 - "Transient diabetes insipidus following Escherichia coli meningitis complicated by ventriculoperitoneal shunt."
4.	Salvage Therapy 12/01/2008 - "A man with Escherichia coli meningitis and bacteremia, while on dexamethasone, developed Strongyloides hyperinfection syndrome and died despite salvage therapy with subcutaneous ivermectin. "
5.	Electrodes (Electrode) 01/01/1991 - "A case of Escherichia coli meningitis in a newborn boy is described which seemed to be related to the use of a screwed top scalp electrode for perinatal monitoring. " 01/01/1991 - "Scalp electrode associated neonatal Escherichia coli meningitis--a case report."