trkB Receptor

A protein-tyrosine kinase receptor that is specific for BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; neurotrophin 4 and neurotrophin 5. It is widely expressed in nervous tissue and plays a role in mediating the effects of neurotrophins on growth and differentiation of neuronal cells.

Also Known As:

Networked: 187 relevant articles (4 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Xu, Baoji: 5 articles (08/2014 - 07/2003)
2.	McNamara, James O: 4 articles (11/2015 - 01/2004)
3.	Ye, Keqiang: 4 articles (03/2015 - 03/2012)
4.	Thiele, Carol J: 4 articles (12/2011 - 04/2006)
5.	Numakawa, Tadahiro: 3 articles (08/2014 - 05/2010)
6.	Abujamra, Ana Lucia: 3 articles (08/2012 - 01/2010)
7.	Roesler, Rafael: 3 articles (08/2012 - 01/2010)
8.	Schwartsmann, Gilberto: 3 articles (08/2012 - 01/2010)
9.	Castrén, Eero: 3 articles (06/2012 - 06/2004)
10.	Hohlfeld, Reinhard: 3 articles (03/2012 - 01/2002)

Related Diseases

1.	Stroke (Strokes) 01/01/2011 - "In the acute intervention study, T and T+R, but not R alone, improved NO, reduced infarct volume, inflammation (TNFα), and induced TrkB receptor and neuronal survival in comparison to V. T, R or T+R had similar beneficial effects on stroke incidence and NO in hypertensive rats, confirming BP reduction as determinant factor in stroke prevention. " 12/24/1996 - "Brain-derived neurotrophic factor and its receptor, trkB, are thought to play a crucial role for protection against neuronal death induced by brain ischemia, such as in stroke. "
2.	Anoxia (Hypoxia) 05/01/2013 - "TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia." 08/01/2015 - "TrkB receptor expression was upregulated in primary AMCs and in immortalized chromaffin (MAH) cells exposed to CHox; this effect was absent in MAH cells deficient in the transcription factor, hypoxia inducible factor (HIF)-2α. " 08/01/2015 - "We investigated the role of the neurotrophin BDNF signalling via the TrkB receptor in rat adrenomedullary chromaffin cells (AMCs) exposed to normoxia (Nox; 21% O2) and chronic hypoxia (CHox; 2% O2) in vitro for ∼ 48 h. " 05/01/2013 - "In this study, we investigated the effects of a bioactive high-affinity TrkB receptor agonist 7,8- dihydroxyflavone (7,8 DHF) on neonatal brain injury in female and male mice after hypoxia ischemia (HI). " 05/11/2007 - "We report here that NTRK2, which encodes the TrkB receptor tyrosine kinase, is an oxygen-regulated gene, whose expression is stimulated by the hypoxia-inducible factor-1 (HIF-1). "
3.	Inflammation 01/01/2011 - "Forty-eight h after MCAO, infarct volume by MRI, neuronal survival, inflammation factors and neurotrophin receptor (TrkB) were analysed. " 07/31/2006 - "We examined the expression of the brain-derived neurotrophic factor receptor trkB in response to inflammation. " 01/01/2011 - "In the acute intervention study, T and T+R, but not R alone, improved NO, reduced infarct volume, inflammation (TNFα), and induced TrkB receptor and neuronal survival in comparison to V. T, R or T+R had similar beneficial effects on stroke incidence and NO in hypertensive rats, confirming BP reduction as determinant factor in stroke prevention. " 01/01/2011 - "However, the precise role of BDNF and trkB receptor in the primary sensory neurons of dorsal root ganglia (DRG) during inflammation remains to be clarified. " 08/03/1999 - "C-fiber electrical activity also increases BDNF expression in the DRG, and both inflammation and activity increase full-length TrkB receptor levels in the dorsal horn. "
4.	Huntington Disease (Huntington's Disease) 01/01/2014 - "A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease." 07/02/2014 - "Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease." 06/15/2013 - "Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease." 02/01/2006 - "Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain." 01/01/2015 - "Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease."
5.	Brain Ischemia (Cerebral Ischemia) 01/01/2013 - "Here, we assessed the expressions of NT-4 and its receptor, trkB, following cerebral ischemia and hypothesized that exercise changes the expressions of NT-4 and trkB. " 12/24/1996 - "Brain-derived neurotrophic factor and its receptor, trkB, are thought to play a crucial role for protection against neuronal death induced by brain ischemia, such as in stroke. "

Related Drugs and Biologics

1.	trkB Receptor
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Conditioned Culture Media
4.	neurotrophin 4
5.	Protein-Tyrosine Kinases (Tyrosine Kinase)
6.	Messenger RNA (mRNA)
7.	Ligands
8.	6,7-dihydroxyflavone
9.	N-Methylaspartate (NMDA)
10.	Bombesin Receptors (Bombesin Receptor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)