Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)

A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4.

Also Known As:

Nerve Growth Factor Receptor, Low Affinity; NGF Receptor; Receptor, Nerve Growth Factor; GP80-LNGFR; Neurotrophin Receptor p75; Neurotropin Receptor p75; gp75 NGFR; p75 Neurotrophin Receptor; GP80 LNGFR; NGFR, gp75; Neurotrophin Receptor, p75; Receptor p75, Neurotrophin; Receptor p75, Neurotropin; Receptor, NGF; Receptor, p75 Neurotrophin; p75, Neurotrophin Receptor; p75, Neurotropin Receptor; NGFR Protein; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity

Networked: 778 relevant articles (18 outcomes, 91 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Nerve Growth Factor Receptors: 526
        Nerve Growth Factor Receptor: 778

Experts

1.	Longo, Frank M: 13 articles (01/2022 - 10/2002)
2.	Massa, Stephen M: 8 articles (01/2020 - 09/2006)
3.	Ohtori, Seiji: 8 articles (10/2015 - 12/2004)
4.	Takahashi, Kazuhisa: 8 articles (10/2015 - 12/2004)
5.	Yang, Tao: 7 articles (01/2022 - 01/2008)
6.	Coulson, Elizabeth J: 7 articles (01/2021 - 08/2006)
7.	Rogers, Mary-Louise: 6 articles (01/2022 - 01/2014)
8.	Zhou, Xin-Fu: 6 articles (07/2019 - 02/2013)
9.	Okumura, Tomoyuki: 6 articles (07/2017 - 09/2006)
10.	Shimada, Yutaka: 6 articles (07/2017 - 09/2006)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 02/01/2015 - "Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease." 07/10/2023 - "Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease." 02/06/2023 - "The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer's Disease." 02/01/2023 - "The extracellular domain (p75ECD) of p75 neurotrophin receptor (p75NTR) antagonizes Aβ neurotoxicity and promotes Aβ clearance in Alzheimer's disease (AD). " 01/01/2023 - "We briefly discuss the design and goals of a recent clinical trial of p75 neurotrophin receptor modulation in patients with mild to moderate Alzheimer's disease. "
2.	Melanoma (Melanoma, Malignant) 11/01/2010 - "P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma." 02/01/2012 - "Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor." 02/01/2011 - "The antibody against NGFR (low affinity nerve growth factor receptor, also known as p75) stains cells of desmoplastic melanoma with high sensitivity; however, the specificity of this marker is not well established. " 03/01/2010 - "Low-affinity nerve growth factor receptor (P75 NGFR) as a marker of perineural invasion in malignant melanomas." 01/01/2004 - "p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells."
3.	Neoplasms (Cancer) 05/01/2013 - "The objective of this study is to test the use of p75 neurotrophin receptor (p75NTR) as an adjunct aid in classification of these tumors. " 01/01/2022 - "p75NTR (p75 neurotrophin receptor) can inhibit tumor growth by inducing cell cycle arrest and regulating cell cycle arrest and apoptotic cell death. " 01/01/2020 - "Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy." 01/01/2020 - "It inhibits the NF-κB pathway and strongly induces the expression of nerve growth factor receptor (NGFR) in preclinical cancer models. " 10/25/2016 - "The nerve growth factor receptor (NGFR) has been observed to be expressed on a subset of cells in OSCC, and NGFR+ cells have greater tumor-initiating capacity in vivo. "
4.	Cognitive Dysfunction 02/04/2002 - "The present study examined the expression of the low affinity p75 neurotrophin receptor (p75(NTR)), an excellent marker of CBF neurons, in postmortem tissue derived from clinically well-characterized individuals who have been classified as having no cognitive impairment (NCI), mild cognitive impairment (MCI), and mild AD. " 01/15/2023 - "Here, we probed into the role of p75 neurotrophin receptor (p75NTR) in cognitive dysfunction in AD. " 01/01/2019 - "Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor." 06/20/2017 - "The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction." 01/01/2018 - "The p75 neurotrophin receptor might mediate sepsis-induced synaptic and cognitive impairments."
5.	Brain Ischemia (Cerebral Ischemia) 06/01/2001 - "The survival of different neuron types and the expression of the p75 neurotrophin receptor (p75(NTR)) after focal cerebral ischemia were studied in the mouse striatum using immunocytochemical and histochemical techniques and stereological procedures. " 08/01/1998 - "Our data suggest that the NGF/receptor system may play a role in the astrocyte/neuron interaction under certain pathological conditions, such as focal cerebral ischemia." 08/01/1998 - "In this experiment, we studied the possible involvement of the NGF/receptor system in the ischemic injury of cortical neurons after focal cerebral ischemia in rats. " 06/01/1998 - "Focal cerebral ischemia in rats induces expression of P75 neurotrophin receptor in resistant striatal cholinergic neurons." 01/01/2021 - "A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia."

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Proteins (Proteins, Gene)
5.	Nerve Growth Factor Receptors (Neurotrophin Receptors)
6.	Messenger RNA (mRNA)
7.	Protein-Tyrosine Kinases (Tyrosine Kinase)
8.	Cholinergic Agents (Cholinergics)
9.	Amyloid (Amyloid Fibrils)
10.	trkA Receptor

Related Therapies and Procedures

1.	Acupuncture Therapy
2.	Intranasal Administration
3.	Therapeutics
4.	Oral Administration
5.	Transcranial Magnetic Stimulation