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Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)

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A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4.

Also Known As:

Nerve Growth Factor Receptor, Low Affinity; NGF Receptor; Receptor, Nerve Growth Factor; GP80-LNGFR; Neurotrophin Receptor p75; Neurotropin Receptor p75; gp75 NGFR; p75 Neurotrophin Receptor; GP80 LNGFR; NGFR, gp75; Neurotrophin Receptor, p75; Receptor p75, Neurotrophin; Receptor p75, Neurotropin; Receptor, NGF; Receptor, p75 Neurotrophin; p75, Neurotrophin Receptor; p75, Neurotropin Receptor; NGFR Protein; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity

Networked: 564 relevant articles (12 outcomes, 64 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Peptide Receptors: 579
        Growth Factor Receptors: 766
        Nerve Growth Factor Receptors: 235
        Nerve Growth Factor Receptor: 564

Experts

1.	Takahashi, Kazuhisa: 8 articles (10/2015 - 12/2004)
2.	Ohtori, Seiji: 8 articles (10/2015 - 12/2004)
3.	Longo, Frank M: 7 articles (01/2014 - 10/2002)
4.	Massa, Stephen M: 6 articles (01/2014 - 09/2006)
5.	Lazarovici, Philip: 6 articles (06/2010 - 06/2003)
6.	Yamauchi, Kazuyo: 5 articles (10/2015 - 09/2008)
7.	Yamashita, Masaomi: 5 articles (12/2010 - 09/2008)
8.	Orita, Sumihisa: 5 articles (12/2010 - 09/2008)
9.	Inoue, Gen: 5 articles (12/2010 - 09/2008)
10.	Djakiew, Daniel: 5 articles (11/2008 - 03/2002)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 11/01/2010 - "P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma." 02/01/2012 - "Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor." 02/01/2011 - "The antibody against NGFR (low affinity nerve growth factor receptor, also known as p75) stains cells of desmoplastic melanoma with high sensitivity; however, the specificity of this marker is not well established. " 03/01/2010 - "Low-affinity nerve growth factor receptor (P75 NGFR) as a marker of perineural invasion in malignant melanomas." 01/01/2004 - "p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells."
2.	Neoplasms (Cancer) 05/01/2013 - "The objective of this study is to test the use of p75 neurotrophin receptor (p75NTR) as an adjunct aid in classification of these tumors. " 08/01/2015 - "Expression of the high-affinity nerve growth factor receptor TrkA has been shown to be associated with PNI in noncutaneous neoplasms. " 01/01/2015 - "p75 neurotrophin receptor (p75NTR) has been reported to play important roles in various cancer types. " 03/01/2014 - "We have identified a ligand-independent mechanism whereby the tumor suppressor, TP53, induces nerve growth factor receptor, NTRK1, phosphorylation at Y674/Y675 (NTRK1-pY674/pY675), via the repression of the NTRK1-phosphatase, PTPN6. " 07/01/2012 - "Intriguingly, the expression levels of CRT and NGF receptor TrkA were highly correlated in NBs with differentiated histology, and the coexistence of CRT and TrkA in NB tumors synergistically predicted a better 5-year survival rate. "
3.	Alzheimer Disease (Alzheimer's Disease) 02/01/2015 - "Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease." 01/01/2014 - "The p75 neurotrophin receptor (p75NTR) is involved in degenerative mechanisms related to Alzheimer's disease (AD). " 01/01/2014 - "Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75NTR). " 08/01/2013 - "The p75 neurotrophin receptor (p75(NTR)) is associated with multiple mechanisms linked to Alzheimer's disease (AD); hence, modulating its function might confer therapeutic effects. " 01/01/2012 - "The pan-specific p75 neurotrophin receptor (p75(NTR)) is believed to play an important role in the pathogenesis of Alzheimer's disease (AD). "
4.	Glioma (Gliomas) 02/06/2015 - "Previously, we have shown that p75 neurotrophin receptor is required for glioma invasion and proliferation. " 01/01/2015 - "Modulation of p75 neurotrophin receptor under hypoxic conditions induces migration and invasion of C6 glioma cells." 03/21/2014 - "Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of human glioma cells. " 12/17/2010 - "A research group demonstrated recently that the multifunctional signaling protein neurotrophin receptor p75(NTR) is a central regulator for glioma invasion. " 11/25/2008 - "The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. "
5.	Pheochromocytoma 08/16/1996 - "Using pheochromocytoma-derived cell lines, we show that individual tyrosines within the nerve growth factor receptor TrkA are phosphorylated in a non-coordinate fashion following receptor activation. " 12/08/1982 - "Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells." 06/01/1979 - "Properties of the nerve growth factor receptor of a clonal line of rat pheochromocytoma (PC12) cells." 08/01/1993 - "Immunolocalization of the LNGFR and the high-affinity component of the NGF receptor, trk (HNGFR) was studied by electron microscopic morphometric analysis on cultured PC12 pheochromocytoma cells, C6 glioma cells and neonatal rat dorsal root ganglia neurons using a double immunogold labeling technique. " 01/01/1983 - "A comparison of binding properties and structure of NGF receptor on PC12 pheochromocytoma and A875 melanoma cells."

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
3.	Messenger RNA (mRNA)
4.	Brain-Derived Neurotrophic Factor (BDNF)
5.	Nerve Growth Factor Receptors (Neurotrophin Receptors)
6.	Protein-Tyrosine Kinases (Tyrosine Kinase)
7.	Small Interfering RNA (siRNA)
8.	Amyloid (Amyloid Fibrils)
9.	Proteins (Proteins, Gene)
10.	trkA Receptor

Related Therapies and Procedures

1.	Intranasal Administration
2.	Therapeutics
3.	Intraperitoneal Injections
4.	Transplants (Transplant)
5.	Axotomy