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Matrix Metalloproteinase 8 (Neutrophil Collagenase)

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A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.

Also Known As:

Neutrophil Collagenase; MMP-8 Metalloproteinase; MMP8 Metalloproteinase; Matrix Metalloproteinase-8; Collagenase 2; Collagenase, Fibroblast; Collagenase, Neutrophil; MMP 8 Metalloproteinase; Metalloproteinase 8, Matrix; Metalloproteinase, MMP-8; Metalloproteinase, MMP8; Metalloproteinase-8, Matrix; Collagenase-2; Fibroblast Collagenase

Networked: 245 relevant articles (6 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sorsa, Timo: 32 articles (02/2016 - 01/2002)
2.	Sorsa, T: 21 articles (02/2015 - 05/2000)
3.	Tervahartiala, Taina: 19 articles (02/2016 - 02/2007)
4.	Yoon, Bo Hyun: 13 articles (01/2015 - 01/2002)
5.	Romero, Roberto: 11 articles (05/2014 - 01/2002)
6.	Tervahartiala, T: 7 articles (02/2015 - 09/2005)
7.	Park, Chan-Wook: 7 articles (01/2015 - 10/2004)
8.	Salo, Tuula: 7 articles (10/2014 - 11/2002)
9.	Mäntylä, Päivi: 6 articles (02/2016 - 08/2003)
10.	Jun, Jong Kwan: 6 articles (01/2015 - 10/2004)

Related Diseases

1.	Inflammation 01/01/2011 - "The aim of the study was to evaluate the efficacy of Parodontax® (GlaxoSmith-Kline, Bühl, Germany) on the signs gingival inflammation and the enzyme activity of matrix metalloproteinase-8 (aMMP-8) in the gingival crevicular fluid. " 01/01/2013 - "The aim of this study was to evaluate the signs of gingival inflammation and the enzyme activity of matrix metalloproteinase-8 (aMMP-8) in the gingival crevicular fluid of pregnant women. " 10/01/2004 - "Matrix metalloproteinase-8 was used because previous studies indicated that this was a sensitive and specific index of inflammation and that is correlated with the amniotic fluid white blood cell count. " 05/01/2010 - "Intraamniotic inflammation was defined as an elevated amniotic fluid (AF) matrix metalloproteinase-8 concentration (>23 ng/mL). " 01/01/2010 - "Intra-amniotic inflammation was defined as an elevated AF matrix metalloproteinase-8 (MMP-8) concentration (>23 ng/mL). "
2.	Sepsis (Septicemia) 02/01/2012 - "Genetic and pharmacologic inhibition of matrix metalloproteinase-8 leads to improved survival and a blunted inflammatory profile in a murine model of sepsis. " 02/01/2015 - "Systemic matrix metalloproteinase-8 and tissue inhibitor of metalloproteinases-1 levels in severe sepsis-associated coagulopathy." 01/01/2014 - "Matrix metalloproteinase-8 inhibitors mitigate sepsis-induced myocardial injury in rats." 02/01/2012 - "A murine model of sepsis was used to explore the effect of genetic and pharmacologic inhibition of matrix metalloproteinase-8 on the inflammatory response to sepsis. " 02/01/2012 - "We further corroborate the role of matrix metalloproteinase-8 in sepsis in a murine model. "
3.	Neoplasms (Cancer) 11/01/2003 - "We generated mice deficient in collagenase-2 (Mmp8), an MMP mainly produced by neutrophils in inflammatory reactions and detected in some malignant tumors. " 11/01/2003 - "Loss of collagenase-2 confers increased skin tumor susceptibility to male mice." 01/01/1985 - "Matrix influence on the tumor cell stimulation of fibroblast collagenase production." 01/01/2011 - "To investigate the effect of intratumoral administration of collagenase-2 on liposomal drug accumulation and diffusion in solid tumor xenografts. " 01/01/2015 - "Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice."
4.	Tongue Neoplasms (Tongue Neoplasm) 07/01/2010 - "Expression of matrix metalloproteinase-8 (MMP-8) in tongue cancer cells has been associated with an improved prognosis. " 02/26/2008 - "Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer."
5.	Shock 01/01/2014 - "Inhibition of neutrophil collagenase/MMP-8 and gelatinase B/MMP-9 and protection against endotoxin shock." 08/15/2005 - "Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock." 01/01/2014 - "Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). "

Related Drugs and Biologics

1.	Matrix Metalloproteinase 9 (Gelatinase B)
2.	Liposomes (Liposome)
3.	Collagenases (Collagenase)
4.	Matrix Metalloproteinase 8 (Neutrophil Collagenase)
5.	Tissue Inhibitor of Metalloproteinase-1
6.	Leukocyte Elastase (Neutrophil Elastase)
7.	Dinoprostone (PGE2)
8.	Matrix Metalloproteinase 1 (Interstitial Collagenase)
9.	Doxycycline (Vibramycin)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplants (Transplant)
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
4.	Root Planing
5.	Oral Hygiene (Dental Hygiene)