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Matrix Metalloproteinase 7 (Matrilysin)

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The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.

Also Known As:

Matrilysin; MMP-7 Metalloproteinase; MMP7 Metalloproteinase; Matrix Metalloproteinase-7; MMP 7 Metalloproteinase; Metalloproteinase 7, Matrix; Metalloproteinase, MMP-7; Metalloproteinase, MMP7; Metalloproteinase-7, Matrix

Networked: 460 relevant articles (13 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Metalloproteases: 2318
        Metalloendopeptidases: 49
        Matrix Metalloproteinases: 8496
        Secreted Matrix Metalloproteinases: 9
        Matrix Metalloproteinase 7: 460
        human MMP7 protein
      - Endopeptidases: 212
        Metalloendopeptidases: 49
        Matrix Metalloproteinases: 8496
        Secreted Matrix Metalloproteinases: 9
        Matrix Metalloproteinase 7: 460
        human MMP7 protein

Experts

1.	Matrisian, Lynn M: 8 articles (08/2009 - 06/2002)
2.	Sang, Qing-Xiang Amy: 7 articles (01/2013 - 09/2002)
3.	McGuire, John K: 6 articles (04/2014 - 06/2003)
4.	Parks, William C: 6 articles (03/2013 - 11/2002)
5.	Yamamoto, Hiroyuki: 6 articles (08/2009 - 01/2003)
6.	Adachi, Yasushi: 6 articles (08/2009 - 01/2003)
7.	Miyazaki, Kaoru: 6 articles (03/2009 - 03/2002)
8.	Park, Hyun I: 5 articles (01/2010 - 09/2002)
9.	Imai, Kohzoh: 5 articles (08/2009 - 01/2003)
10.	Higashi, Shouichi: 5 articles (03/2009 - 11/2003)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2002 - "The mean matrilysin labeling index (LI) of gamma-infiltration tumors at the invasive front was significantly greater than that of alpha- and beta-infiltration tumors (P =.01). " 03/01/2004 - "The results of this study indicate that expression of matrix metalloproteinase-7 is related to both the invasiveness of colorectal epithelial tumors and the disturbance of the pit pattern on the tumor surface." 11/01/2001 - "The goal of the current study was to reconcile the proapoptotic and tumor-promoting functions of matrilysin. " 05/01/1998 - "Immunohistochemical study with anti-matrilysin monoclonal antibody revealed that matrilysin was mainly expressed on cancer cells but not or very weakly expressed on other cells. " 07/29/1997 - "In the present study, we analyzed matrilysin-producing cells in various human cancer tissues by immunohistochemistry and in situ hybridization. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2012 - "The purpose of this study was to evaluate expression and prognostic value of matrix metalloproteinase-7 (MMP-7) in colorectal cancer (CRC) patients. " 08/01/2003 - "The results of this study suggest that E1AF, the expression of which is closely correlated with the expression of MMP-1 and matrilysin, plays a key role in the progression of colorectal cancer." 02/01/2003 - "The aim of this study was to assess the validity of matrilysin as a prognostic marker of colorectal cancers. " 09/20/2001 - "The aim of our study was to assess the validity of matrilysin as a prognostic marker of colorectal cancers. " 05/18/2001 - "This study was undertaken to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas. "
3.	Carcinoma (Carcinomatosis) 07/15/1999 - "Patients with matrilysin-positive carcinoma had a significantly shorter disease-free and overall survival time than did those with a matrilysin-negative one (P < 0.0001). " 07/01/2002 - "The aim of this study was to determine whether matrilysin has clinicopathological and prognostic significance in pancreatic carcinoma. " 07/01/2015 - "Matrix metalloproteinase 7 expression in ampullary carcinoma." 01/01/2013 - "Human endometase/matrilysin-2/matrix metalloproteinase-26 (MMP-26) is an endopeptidase mostly produced by human carcinoma cells. " 01/15/2010 - "Endometase (matrilysin 2 or MMP-26) is a putative early biomarker for human carcinomas. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2015 - "In the present study, we examined the relationship between Reg4 and matrix metalloproteinase-7 (MMP-7) expression in CRC, particularly with regard to metastasis. " 05/30/2015 - "Matrix metalloproteinase-7 (MMP-7) is over-expressed by CRC cells and supposed to play a major role in CRC cell diffusion and metastasis. " 01/01/2014 - "Clinicopathological assessment revealed that higher matrix metalloproteinase-7 expression is associated with deeper invasion (pooled OR = 3.20; 95% CI = 1.14 - 8.96; P = 0.026), higher TNM stage (pooled OR = 3.67; 95% CI = 2.281-5.99; P<0.001), lymph node metastasis (pooled OR = 2.84; 95% CI = 1.89 - 4.25; P<0.001), and distant metastasis (pooled OR = 3.68; 95% CI = 1.85 - 7.29; P<0.001), but not with histological grade. " 06/01/2013 - "High urinary matrix metalloproteinase 7 (MMP 7) levels were previously shown to be correlated with the presence of lymph node metastases. " 05/01/2009 - "Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/01/2014 - "Matrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinoma." 09/01/2011 - "Association of matrix metalloproteinase-7 (-181A>G) polymorphism with risk of esophageal squamous cell carcinoma in Kashmir Valley." 12/01/2008 - "In conclusion, active matrix metalloproteinase-7 expression was associated with more aggressive buccal squamous cell carcinomas." 12/01/2008 - "We investigated the expression of active matrix metalloproteinase-7, using tissue microarray, immunohistochemistry, and western blotting, in oral tissues from 24 patients with buccal squamous cell carcinoma, and correlated the findings with clinicopathological features. " 12/01/2008 - "Protein microarrays have shown that matrix metalloproteinase-7 is upregulated in head and neck squamous cell carcinomas, but its role in local tissue invasion is still uncertain. "

Related Drugs and Biologics

1.	beta Catenin
2.	Epidermal Growth Factor Receptor (EGF Receptor)
3.	Osteopontin
4.	Epidermal Growth Factor (EGF)
5.	kalinin
6.	Cyclin B1
7.	Interleukin-1beta (Interleukin 1 beta)
8.	Epithelial Sodium Channel
9.	TNF-Related Apoptosis-Inducing Ligand
10.	TNF-Related Apoptosis-Inducing Ligand Receptors

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Radiotherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Adjuvant Chemotherapy