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Matrix Metalloproteinase 9 (Gelatinase B)

Subscribe to New Research on Matrix Metalloproteinase 9

An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.

Also Known As:

Gelatinase B; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; MMP-9 Metalloproteinase; MMP9 Metalloproteinase; Matrix Metalloproteinase-9; 92 kDa Gelatinase; 92 kDa Type IV Collagenase; MMP 9 Metalloproteinase; Metalloproteinase 9, Matrix; Metalloproteinase, MMP-9; Metalloproteinase, MMP9

Networked: 3183 relevant articles (43 outcomes, 337 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Metalloproteases: 2318
        Metalloendopeptidases: 49
        Matrix Metalloproteinases: 8496
        Secreted Matrix Metalloproteinases: 9
        Matrix Metalloproteinase 9: 3183
        pro-matrix metalloproteinase 9: 94
        MMP-9-hemopexin: 3
        mouse Mmp9 protein
        Collagenases: 2958
        Matrix Metalloproteinase 9: 3183
        pro-matrix metalloproteinase 9: 94
        MMP-9-hemopexin: 3
        mouse Mmp9 protein
        Gelatinases: 1831
        Matrix Metalloproteinase 9: 3183
        pro-matrix metalloproteinase 9: 94
        MMP-9-hemopexin: 3
        mouse Mmp9 protein
      - Endopeptidases: 212
        Metalloendopeptidases: 49
        Matrix Metalloproteinases: 8496
        Secreted Matrix Metalloproteinases: 9
        Matrix Metalloproteinase 9: 3183
        pro-matrix metalloproteinase 9: 94
        MMP-9-hemopexin: 3
        mouse Mmp9 protein
        Collagenases: 2958
        Matrix Metalloproteinase 9: 3183
        pro-matrix metalloproteinase 9: 94
        MMP-9-hemopexin: 3
        mouse Mmp9 protein
        Gelatinases: 1831
        Matrix Metalloproteinase 9: 3183
        pro-matrix metalloproteinase 9: 94
        MMP-9-hemopexin: 3
        mouse Mmp9 protein

Experts

1.	Opdenakker, Ghislain: 48 articles (12/2015 - 01/2002)
2.	Van den Steen, Philippe E: 24 articles (01/2014 - 03/2002)
3.	Opdenakker, G: 20 articles (12/2008 - 01/2000)
4.	Yang, Shun-Fa: 16 articles (10/2015 - 07/2002)
5.	Lo, Eng H: 15 articles (03/2013 - 11/2002)
6.	Rao, Jasti S: 14 articles (01/2013 - 11/2002)
7.	Tanus-Santos, Jose E: 14 articles (11/2012 - 09/2005)
8.	Hsieh, Yih-Shou: 13 articles (01/2015 - 07/2002)
9.	Lindsey, Merry L: 12 articles (08/2015 - 08/2005)
10.	Zhang, Wei: 11 articles (06/2014 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 02/15/2012 - "In particular, mast cells are essential for the outgrowth of early-stage tumors due to their matrix metalloproteinase-9 production, become dispensable in advanced-stage, post-epithelial-to-mesenchymal transition, and are protective against neuroendocrine prostate tumor variants. " 06/28/2015 - "An immunohistochemical study of integrin αvβ6 and matrix metalloproteinase-9 (MMP-9) was performed on tissue microarrays of 200 spots, including 100 cases of colon tumors. " 01/01/2010 - "Further studies of tumors and primary epidermal keratinocyte cultures showed that matrix metalloproteinase 9 (MMP-9) levels and cell proliferation decreased in K5-VILIP-1 mice when compared with their wild counterparts. " 04/01/2008 - "Previous studies in the K14-HPV/E(2) mouse model of cervical carcinogenesis demonstrated that infiltrating macrophages are the major source of matrix metalloproteinase 9 (MMP-9), a metalloprotease important for tumor angiogenesis and progression. " 10/08/2007 - "Previous studies have demonstrated raised serum levels of matrix metalloproteinase 9 (sMMP-9) in a range of cancers. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 07/01/2012 - "Moreover, repopulated bone marrow cells ameliorated liver fibrosis through higher expression of matrix metalloproteinase-9, consistent with improved liver functions and better survival rate. " 01/01/2011 - "Moreover, bone marrow cells infused into the liver improved liver function and ameliorated liver fibrosis with higher expression of matrix metalloproteinase 9 (MMP-9), consistent with improved survival rate. " 08/01/2015 - "Enhanced liver fibrosis in the presence of iNOS was associated with hypoxia-inducible factor-1α stabilization, matrix metalloproteinase-9 expression, and enhanced hepatic DNA damage. " 08/01/2004 - "This study found a correlation between some serum markers [AST/ALT ratio, level of matrix metalloproteinase 9 (MMP9), level of viraemia and HCV serotype] and severity of liver fibrosis in HCV-infected patients. " 01/01/2011 - "Matrix metalloproteinase-9 (MMP-9) is one of the gelatinases that may be important in liver fibrosis. "
3.	Neoplasm Metastasis (Metastasis) 06/01/2012 - "In the present study, we found that in NPC cells, LMP2A upregulated matrix metalloproteinase 9 (MMP9), a metastasis-associated protease. " 05/01/2011 - "Additional studies suggest a mechanism in which Fibulin-5 suppresses metastasis formation by inhibiting production of matrix metalloproteinase 9 (MMP9) and reducing the invasive behavior of fibroblasts. " 11/01/2006 - "All the data in the present study suggested that S100A4 might contribute to HCC invasion and metastasis through two paths of matrix metalloproteinase (MMP9) secretion regulation and strengthened motility and invasion properties." 09/08/2015 - "The metastasis effects of P85 and P123 both in vitro and in vivo were partially attributed to the downregulation of matrix metalloproteinase-9 (MMP-9). " 08/15/2014 - "In addition, an interference of metastasis was also observed in MDA-MB-231 cells through the regulation of the matrix metalloproteinase 9 (MMP-9) releases. "
4.	Fibrosis (Cirrhosis) 04/01/2013 - "A pro-fibrotic role of matrix metalloproteinase-9 (MMP-9) in tubular cell epithelial-mesenchymal transition (EMT) is well established in renal fibrosis; however studies from our group and others have demonstrated some previously unrecognized complexity of MMP-9 that has been overlooked in renal fibrosis. " 05/01/2014 - "Additional targets of miR-326 controlling TGF-β signaling and fibrosis-related pathways were identified, and miR-326 was found to down-regulate profibrotic genes, such as Ets1, Smad3, and matrix metalloproteinase 9, whereas it up-regulates antifibrotic genes, such as Smad7. " 09/01/2013 - "Matrix metalloproteinase-9 deletion is associated with decreased mid-term vein wall fibrosis in experimental stasis DVT." 01/01/2013 - "Matrix metalloproteinase-9 (MMP9) induces fibrosis that causes stiffness of the ECM and impairs differentiation of cardiac stem cells into cardiomyocytes. " 12/01/2012 - "Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice."
5.	Infection 09/01/2010 - "The purpose of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) in the pathogenesis of vascular leakage in patients with dengue virus infection. " 10/01/2015 - " Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. " 08/01/2015 - "Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo." 01/01/2015 - "Increased lung levels of matrix metalloproteinase 9 (MMP9) are frequently observed during respiratory syncytial virus (RSV) infection and elevated MMP9 concentrations are associated with severe disease. " 11/01/2014 - "We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. "

Related Drugs and Biologics

1.	Collagen
2.	Matrix Metalloproteinase 2 (Gelatinase A)
3.	Interleukin-6 (Interleukin 6)
4.	Tissue Inhibitor of Metalloproteinase-1
5.	Transforming Growth Factors (Transforming Growth Factor)
6.	Cyclin D1
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Gelatinases
10.	Matrix Metalloproteinase 1 (Interstitial Collagenase)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplantation (Transplant Recipients)
3.	Adjuvant Chemotherapy
4.	Transcutaneous Electric Nerve Stimulation (TENS)
5.	Drug Therapy (Chemotherapy)