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Pick Disease of the Brain (Pick's Disease)

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A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Also Known As:

Pick's Disease; Brain Atrophy, Circumscribed Lobar; Pick Disease; Picks Disease of Brain; Atrophies, Lobar (Brain); Atrophy, Lobar (Brain); Disease, Pick; Disease, Pick's; Lobar Atrophies (Brain); Picks Disease; Circumscribed Lobar Atrophy of the Brain; Lobar Atrophy (Brain); Lobar Atrophy of the Brain

Networked: 286 relevant articles (5 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease)
2.	Frontotemporal Lobar Degeneration (Semantic Dementia)
3.	Frontotemporal Dementia
4.	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
5.	Dementia (Dementias)

Experts

1.	Ferrer, I: 9 articles (02/2013 - 01/2001)
2.	Trojanowski, John Q: 8 articles (01/2016 - 06/2002)
3.	Lee, Virginia M-Y: 7 articles (01/2016 - 06/2002)
4.	Ferrer, Isidre: 7 articles (12/2014 - 03/2004)
5.	Puig, B: 7 articles (04/2006 - 01/2001)
6.	Miller, Bruce L: 6 articles (12/2013 - 06/2002)
7.	Grossman, Murray: 5 articles (01/2016 - 06/2002)
8.	Tsuchiya, Kuniaki: 5 articles (05/2009 - 05/2003)
9.	Revesz, T: 5 articles (06/2005 - 02/2000)
10.	Arnold, Steven E: 4 articles (01/2016 - 02/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pick Disease of the Brain:

1.	Amyloid (Amyloid Fibrils)IBA 01/01/2005 - "M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple intracellular pathways involving tau phosphorylation and amyloid metabolism." 09/01/1999 - "We present a patient with early-onset Pick's disease in which selective nigral degeneration, KP1 expression of ghost Pick bodies and amyloid P-positive astrocytes were found. " 09/01/1999 - "KP1 expression of ghost Pick bodies, amyloid P-positive astrocytes and selective nigral degeneration in early onset Picks disease." 04/25/1994 - "Accumulation of amyloid precursor protein in brain lesions of patients with Pick disease." 06/01/1996 - "These two subjects, both homozygous for the APOE-epsilon4 allele, were primarily diagnosed as having Creutzfeldt-Jakob disease and Pick's disease in the absence of significant neocortical amyloid deposition. "
2.	alpha-Crystallin B ChainIBA 10/01/1995 - "The remaining brains have frontal lobe degeneration: the use of alpha B-crystallin immunostaining, on these, to detect ballooned neurons may help to define two groups of patients, one of which we believe may represent a variant of Pick's disease. " 08/01/1992 - "alpha B Crystallin was expressed by the majority of ballooned neurons of Pick's disease and CJD, but not by those of the other disorders. " 06/01/1995 - "We studied the distribution of alpha B-crystallin-positive degenerating neurons in cases with progressive supranuclear palsy, and compared them with those in Pick's disease. " 08/01/1992 - "Ubiquitin and srp 27 expression was also restricted to abnormal neurons of Pick's disease and CJD, but the proportion of stained cells was less than that expressing alpha B-crystallin. " 01/01/2008 - "Pick disease (PiD) is a frontotemporal dementia characterized by frontal and temporal atrophy, neuronal loss, gliosis, ballooned neurons that are positive for alpha-B crystallin and neurofilament, and the presence of tau- and ubiquitin-positive Pick bodies. "
3.	CalciumIBA 07/01/1991 - "Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). " 03/01/2007 - "In addition, patients with Pick's disease, which is part of the spectrum of frontotemporal lobar degeneration, showed improvement on calcium EDTA. " 01/01/2001 - "Calcium/calmodulin-dependent kinase II (alpha- and beta-CaM kinase II), and phosphorylated mitogen-activated extracellular signal-regulated protein kinase (MAPK/ERK-P), phosphorylated protein kinase of 38 kDa (p38-P) and phosphorylated stress-activated protein kinase (SAPK/JNK-P) expression have been examined in Alzheimer disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). "
4.	Glucose (Dextrose)FDA LinkGeneric 01/01/1993 - "Patients with Pick's disease revealed decreased glucose metabolism in frontal and temporal regions. " 12/01/1986 - "[Disorders of glucose metabolism in Pick's disease]." 12/01/1986 - "Pick's disease can be differentiated against presenile dementia represented by Alzheimer's disease in that the pattern of reduced metabolism characteristic of Alzheimer's disease is different from that of Pick's disease where in accordance with the clinical syndrome the glucose metabolism in the frontal and temporobasal regions in reduced, involving also the structures of the hippocampus and an equally significant reduction of glucose metabolism in the caudate nucleus. "
5.	NeuropeptidesIBA 01/01/2015 - "We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with neurotrophic effects, ameliorates the pathology in amyloid precursor protein transgenic (tg) mouse model of AD and 4R tau, however it is unclear if CBL ameliorates the deficits and neuropathology in the mouse model of Pick's disease over expressing 3R tau. "
6.	Edetic Acid (EDTA)FDA Link 03/01/2007 - "In addition, patients with Pick's disease, which is part of the spectrum of frontotemporal lobar degeneration, showed improvement on calcium EDTA. "
7.	rivastigmine (Exelon)FDA LinkGeneric 06/01/2009 - "We report a case of frontotemporal dementia, Pick's disease, which improved with rivastigmine treatment. " 06/01/2009 - "[Rivastigmine in a case of autopsy proved frontotemporal dementia (Pick's disease)]."
8.	tau Proteins (tau Protein)IBA 01/01/1996 - "In the present study, tau protein alterations were studied in one corticobasal degeneration and seven Pick's disease cases using specific immunological probes. " 01/18/2011 - "Abnormal deposits of hyperphosphorylated and ubiquitinated tau protein are present in 30% of cases, which include the classic presentation of Pick disease with argyrophilic, intraneuronal inclusions known as Pick bodies. " 02/01/2008 - "Even though the inclusions are morphologically different, flame-shape structure for AD vs. spherical structure for Pick disease, both have filaments mainly composed of tau protein. " 12/01/2006 - "Surviving VENs were often dysmorphic, with pathological tau protein accumulation in Pick's disease. " 02/16/2001 - "The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease."
9.	Protein Isoforms (Isoforms)IBA 10/01/2006 - "Bi-dimensional gel electrophoresis and western blotting also disclosed increased amounts and numbers of glial acidic protein isoforms in the frontal cortex in Pick's disease. " 06/13/2005 - "Similarly, there was no significant difference in the 4R/3R ratio between Pick's disease cases and controls, indicating that the predominance of tau3R protein in PiD reflects post-translational modifications of specific isoforms. " 10/01/2003 - "In addition, the results of the RD3 and ET3 immunostains clearly explain for the first time the presence of both 3R and 4R tau isoforms in preparations of insoluble tau from some Pick's disease cases." 04/01/2001 - "Filaments assembled in vitro from single isoforms were similar in mass/nm length, but less dense than AD-PHFs and Pick's disease filaments. " 01/01/2000 - "In Pick's disease, only phosphorylated 3R-tau isoforms aggregate into filaments and are characterized by another major tau doublet (tau 55 and 64). "
10.	Apolipoproteins E (ApoE)IBA 01/01/2013 - "The presence of truncated apoE within Pick bodies suggests a broader role of apoE beyond AD and raises the question as to whether this protein contributes to pathogenesis associated with Pick's disease. " 01/01/2013 - "To examine a possible role of apoE in Pick's disease, an immunohistochemical analysis was performed utilizing a novel site-directed antibody that is specific for an amino-terminal fragment of apoE. " 12/01/2003 - "Neurocognitive data indicated a progressive right hemispheric syndrome, insight was preserved, and ApoE was 3/3, but tau concentrations and beta-amyloid(42) were highly consistent with cut-offs for AD; the differential fell on the Pick's disease/frontotemporal degeneration spectrum. " 04/01/2002 - "Furthermore, the apolipoprotein epsilon4 allele (APOE epsilon4) may be associated with Pick disease. " 01/01/1998 - "We carried out immunohistochemical examination of apolipoprotein E (apoE) in brains from two patients with Pick's disease. "

Therapies and Procedures

1.	Lasers (Laser) 03/01/2006 - "By utilizing a novel combinatorial method of a Laser Microdissection System and Western blot analysis, we demonstrate that a distinct isoform of abnormally phosphorylated tau (69 kDa, Tau 69) predominantly aggregated in laser-microdissected Pick bodies (PBs) in sporadic Pick's disease. " 12/01/2005 - "As a model, pick bodies were chosen and laser-microdissected from three different brain regions of two patients with Pick's disease. " 02/01/2008 - "In this study, we used laser scanning confocal microscopy to characterize and compare the processing of tau protein during Pick disease with that found in AD. "
2.	Nursing Care 04/20/1983 - "Nursing care study: a patient with Pick's disease."
3.	Pericardiectomy 01/01/1936 - "Pericardiectomy in a Case of Pick's Disease."
4.	Home Nursing (Nursing, Home) 05/01/2009 - "Nursing home residents diagnosed with AD (NINCDS/ADRDA criteria) or the behavioral variant of FTD (Frontotemporal Dementia and Pick's Disease Working Group criteria) were included in the research group. "
5.	Drug Therapy (Chemotherapy) 03/01/2011 - "Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal dementia" OR "fronto-temporal dementia" OR "fronto-temporal degeneration" OR "Pick's disease" OR "Pick's atrophy" OR "semantic dementia" OR "progressive aphasia" AND "pharmacotherapy" OR "treatment" OR "efficacy" OR "effects" OR "management" was performed in the Medline and Lilacs databases. "