cdc42 GTP-Binding Protein

A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array of cellular functions including cytoskeletal changes, filopodia formation and transport through the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47.

Also Known As:

Cell Division Control Protein 42 Homolog; Cell Division Cycle 42 Protein; G25K GTP-Binding Protein; G25K GTP Binding Protein; G25K GTP Binding Protein, Placental Isoform; GTP-Binding Protein, G25K; GTP-Binding Protein, cdc42; cdc42 GTP Binding Protein; cdc42, p21; G25K GTP-Binding Protein, Placental Isoform; G25K Protein; cdc42 Protein; p21 cdc42

Networked: 28 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cha, Hye Jin: 2 articles (04/2019 - 12/2016)
2.	Kim, Young-Hoon: 2 articles (04/2019 - 12/2016)
3.	Shin, Jisoon: 2 articles (04/2019 - 12/2016)
4.	Yoon, Kyung Sik: 2 articles (04/2019 - 12/2016)
5.	Yun, Jaesuk: 2 articles (04/2019 - 12/2016)
6.	Li, Jin-mei: 2 articles (10/2008 - 08/2007)
7.	Wang, Xue-feng: 2 articles (10/2008 - 08/2007)
8.	Xi, Zhi-qin: 2 articles (10/2008 - 08/2007)
9.	Xiao, Fei: 2 articles (10/2008 - 08/2007)
10.	Chen, Shiyao: 1 article (01/2022)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 09/01/2010 - "In this study, we transfected miR-206 into MDA-MB-231 cells and examined Cdc42 protein expression as well as MMP-2 and MMP-9, which are also associated with metastasis of breast cancer. " 10/01/2022 - "The co‑immunoprecipitation, immunofluorescence and western blot results also revealed that LIS1 binds to cytoplasmic linker protein 170 (CLIP170) to form a protein complex (LIS1/CLIP170), which activates the cell division control protein 42 homolog (Cdc42) signaling pathway to modulate the proliferation and anti‑apoptosis of tumor cells, and enhanced invasion and metastasis by regulating the formation of invadopodia and the expression of MMPs in SACC‑LM cells. "
2.	Breast Neoplasms (Breast Cancer) 09/01/2010 - "In this study, we transfected miR-206 into MDA-MB-231 cells and examined Cdc42 protein expression as well as MMP-2 and MMP-9, which are also associated with metastasis of breast cancer. " 11/01/2019 - "The Rho guanosine triphosphatase (GTPase) Cdc42 (Cell division control protein 42 homolog) is often upregulated by some cell surface receptors and oncogenes in breast cancer. "
3.	Colorectal Neoplasms (Colorectal Cancer) 07/25/2013 - "The purpose of this study was to investigate the role of activated Rho GTPase cell division control protein 42 homolog (Cdc42) in colorectal cancer cell adhesion, migration, and invasion. "
4.	Carcinoma (Carcinomatosis) 07/01/2016 - "PAK1 and CDC42 protein expression in normal cervix, CINI, CINII, CINIII and cervical carcinoma tissues showed a gradually increasing trend. " 07/01/2016 - "This study investigated P21-activated kinase 1 (PAK1) and cell division control protein 42 homolog (CDC42) expression and their correlation with clinicopathological features and prognosis in cervical carcinoma. " 07/01/2016 - "Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma."
5.	Urinary Bladder Neoplasms (Bladder Cancer) 09/01/2015 - "The aim of the present study was to investigate the role of miR-195 in the regulation of bladder cancer cell proliferation and to determine whether cell division control protein 42 homolog (Cdc42)/signal transducer and activator of transcription-3 (STAT3) signaling acts as a downstream effector of miR-195 in bladder cancer cells. " 09/01/2015 - "microRNA-195 inhibits cell proliferation in bladder cancer via inhibition of cell division control protein 42 homolog/signal transducer and activator of transcription-3 signaling."

Related Drugs and Biologics

1.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
2.	p21-Activated Kinases
3.	Phosphotransferases (Kinase)
4.	GTP Phosphohydrolases (GTPases)
5.	Proteins (Proteins, Gene)
6.	cdc42 GTP-Binding Protein
7.	Botulinum Toxins (Botulinum Toxin)
8.	Caspase 3 (Caspase-3)
9.	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)
10.	Proteinase-Activated Receptors

Related Therapies and Procedures

1.	Therapeutics