Anterior Spinal Artery Syndrome

Ischemia or infarction of the spinal cord in the distribution of the anterior spinal artery, which supplies the ventral two-thirds of the spinal cord. This condition is usually associated with ATHEROSCLEROSIS of the aorta and may result from dissection of an AORTIC ANEURYSM or rarely dissection of the anterior spinal artery. Clinical features include weakness and loss of pain and temperature sensation below the level of injury, with relative sparing of position and vibratory sensation. (From Adams et al., Principles of Neurology, 6th ed, pp1249-50)

Also Known As:

Networked: 41 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Paraplegia (Spastic Paraplegia)
2.	Meningeal Carcinomatosis
3.	Post-Dural Puncture Headache
4.	Lacerations
5.	Pick Disease of the Brain (Pick's Disease)

Experts

1.	Huang, Xiang: 1 article (02/2022)
2.	Xiao, Minjia: 1 article (02/2022)
3.	Choi, Byeong Sam: 1 article (10/2020)
4.	Kim, Hae Yu: 1 article (10/2020)
5.	Kwon, John: 1 article (10/2020)
6.	Lee, Sungjoon: 1 article (10/2020)
7.	Aron, Jonathan: 1 article (02/2020)
8.	Blackstock, Adam: 1 article (02/2020)
9.	Drew, Thomas: 1 article (02/2020)
10.	Ghazy, Tamer: 1 article (08/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anterior Spinal Artery Syndrome:

1.	Opiate AlkaloidsIBA 02/01/1992 - "We present three patients with a nontraumatic cervical anterior spinal artery syndrome, two of whom developed painful burning dysaesthesias below the level of spinal cord lesion, refractory to opiate, anticonvulsant and tricyclic antidepressant therapy. "
2.	alpha-Crystallin B ChainIBA 08/01/1992 - "This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcinomatosis, anterior spinal artery syndrome and pellagra. "
3.	UbiquitinIBA 08/01/1992 - "This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcinomatosis, anterior spinal artery syndrome and pellagra. "
4.	Phenol (Carbolic Acid)FDA Link 02/01/1979 - "Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection." 02/01/1979 - "We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain. "
5.	Antiphospholipid AntibodiesIBA 08/01/1991 - "Recovery of anterior spinal artery syndrome in a patient with systemic lupus erythematosus and antiphospholipid antibodies."
6.	Neurofilament ProteinsIBA 08/01/1992 - "This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcinomatosis, anterior spinal artery syndrome and pellagra. "
7.	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 12/01/1993 - "Three patients with symptoms due to the anterior spinal artery syndrome were treated by direct perfusion of dexamethasone sodium phosphate and urokinase into the artery of Adamkiewicz. "
8.	Proteins (Proteins, Gene)FDA Link 08/01/1992 - "This report deals with a comparative study on the expression of alpha B crystallin, ubiquitin, stress-response protein 27 (srp 27), srp 72 and phosphorylated neurofilament protein (pNFP) by ballooned neurons in Pick's disease, Creutzfeldt-Jakob disease (CJD), amyotrophic lateral sclerosis (ALS), leptomeningeal carcinomatosis, anterior spinal artery syndrome and pellagra. "
9.	Tissue Plasminogen Activator (Alteplase)FDA Link 02/01/2022 - "Anterior spinal artery syndrome, intravenous alteplase or not."
10.	Glycerol (Glycerine)FDA LinkGeneric 02/01/1979 - "We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain. "

Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 03/01/2017 - "Anterior Spinal Artery Syndrome Following Coronary Artery Bypass Grafting: a Case Report." 01/01/2017 - "Anterior spinal artery syndrome after double valve replacement and coronary artery bypass surgery." 06/01/2002 - "Anterior spinal artery syndrome after elective coronary artery bypass grafting." 04/01/2005 - "Anterior spinal artery syndrome after minimally invasive direct coronary artery bypass grafting under general combined epidural anesthesia."
2.	Epidural Analgesia 05/01/2001 - "Postoperative epidural analgesia and possible transient anterior spinal artery syndrome." 08/01/2000 - "Anterior spinal artery syndrome masked by epidural analgesia." 11/01/1997 - "We report a case of a patient who developed a postoperative anterior spinal artery syndrome that was masked by the use of epidural analgesia. " 11/01/1997 - "If epidural analgesia is used, opioids may be preferred over local anaesthetics in the immediate postoperative period to prevent masking of an anterior spinal artery syndrome."
3.	Therapeutics 02/01/2004 - "Anterior spinal artery syndrome following periradicular cervical nerve root therapy." 09/01/1987 - "We discussed the therapy of neurogenic bladder due to the anterior spinal artery syndrome." 02/01/1992 - "We present three patients with a nontraumatic cervical anterior spinal artery syndrome, two of whom developed painful burning dysaesthesias below the level of spinal cord lesion, refractory to opiate, anticonvulsant and tricyclic antidepressant therapy. "
4.	Anesthesia 02/01/2015 - "Anterior spinal artery syndrome has rarely been reported as a cause of permanent neurologic complications after neuraxial anesthesia in obstetric patients. " 05/01/1987 - "[Anterior spinal artery syndrome and intradural anesthesia]." 12/01/1984 - "[Massive intracerebral hemorrhage and anterior spinal artery syndrome in etiologic relation to paraspinal anesthesia procedures? "
5.	Catheters 12/01/1984 - "The subject is treated demonstrating two cases of intracerebral haemorrhage and anterior spinal artery syndrome during and following catheter-epidural anaesthesia or spinal anaesthesia, respectively. " 07/01/2002 - "The following complications are presented: needle and catheter-induced nerve injury, post dural puncture headache, anterior spinal artery syndrome, spinal hematoma, septic meningitis, aseptic meningitis, adhesive arachnoiditis, cauda equina syndrome, and transient neurological symptoms. "