rac GTP-Binding Proteins

03/14/2017 - "In the CD133+-U373-tumorsphere xenotransplanted mouse model, suppression of Rac proteins decreased the incidence of tumor formation and inhibited the tumor growth. "
03/14/2017 - "Moreover, knockdown of Rac proteins reduced the sphere forming efficiency of cells derived from these tumors. "
09/01/2016 - "The level of Rac proteins were found to be increased in all stages of cancer. "
12/01/2010 - "Rac proteins are not mutated in most invasive human cancers but are found to be overactive or over-expressed. "
01/01/2021 - "Among human cancers, Rac proteins are highly activated by either overexpression of the genes, up-regulation of the protein, or by mutations that allow the protein to elude normal regulatory signaling pathways. "

11/28/2023 - "This is the first study to identify the contribution of Rac proteins in pterygium. "

06/01/2007 - "Rac proteins of the Rho-like GTPase family, including the ubiquitous Rac1, the hematopoiesis-specific Rac2, and the least-characterized Rac3 play a major role in oncogenic transformation, tumor invasion and metastasis. "
02/01/2000 - "Oncogenic forms of RAS are locked in their active state and transduce signals essential for transformation, angiogenesis, invasion and metastasis via downstream pathways involving the RAF/MEK/ERK cascade of cytoplasmic kinases, the small GTP-binding proteins RAC and RHO, phosphatidylinositol 3-kinase and others. "

05/01/1998 - "These results suggest that reoxygenation injury requires the activation of rac proteins, and that inhibition of rac-dependent pathways may be a useful strategy for the prevention of reperfusion injury in ischemic tissues."

01/01/2015 - "Rac proteins accumulate at specific regions in the wound leading edge cells and Rac-deficient embryos exhibit slower repair kinetics. "