HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

rho GTP-Binding Proteins (rho GTP-Binding Protein)

Subscribe to New Research on rho GTP-Binding Proteins

A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47.

Also Known As:

rho GTP-Binding Protein; P21 (rho)Protein; rho Protein P21; G-Proteins, rho; GTP-Binding Protein, rho; GTP-Binding Proteins, rho; GTPases, rho; P21, rho Protein; rho G Proteins; rho GTP Binding Protein; rho GTP Binding Proteins; rho Small GTP Binding Proteins; rho G-Proteins; rho GTPases; rho Small GTP-Binding Proteins

Networked: 320 relevant articles (3 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zheng, Yi: 9 articles (01/2015 - 03/2004)
2.	Ridley, Anne J: 8 articles (10/2015 - 11/2002)
3.	Wojciak-Stothard, Beata: 6 articles (03/2013 - 11/2002)
4.	Cerione, Richard A: 5 articles (01/2015 - 06/2006)
5.	El-Sibai, Mirvat: 5 articles (02/2014 - 07/2012)
6.	van Golen, Kenneth L: 5 articles (01/2011 - 01/2003)
7.	Lacal, Juan Carlos: 5 articles (01/2008 - 07/2003)
8.	Fiorentini, Carla: 4 articles (06/2015 - 03/2012)
9.	Fabbri, Alessia: 4 articles (06/2015 - 03/2012)
10.	Liu, Na: 4 articles (03/2011 - 03/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/20/2015 - "Additional studies are warranted to evaluate the therapeutic potential of inhibiting Rho GTPases and COX-2 for treating breast cancers. " 02/01/2012 - "Accumulating evidence from basic and clinical studies supports the concept that signaling pathways downstream of Rho GTPases play important roles in tumor development and progression. " 01/01/2012 - "Further studies are needed to better understand the role of Rho-GTPases in cervical cancer progression." 01/01/2009 - "In the present study, we provide the evidence that the expression of Rhob, a member of Rho GTPases with anti-cancer character, remarkably decreased in RAW-GR(-) and RAW264.7 cells transiently transfected with GR-RNAi vector. " 06/01/2005 - "Although early studies proposed a role for Rho GTPases in cellular transformation, this effect was underestimated due to the fact that no genetic mutations affecting Rho-encoding genes were found in tumors. "
2.	Cardiomegaly (Heart Hypertrophy) 03/01/2002 - "(3) Targeting myocardial Rho GTPases by statins may be a novel treatment strategy to prevent cardiac hypertrophy." 05/01/2004 - "However, left ventricular systolic and diastolic function was largely preserved before and after the development of cardiac hypertrophy, indicating that Rho GTPases are not required to maintain ventricular contractile function under basal physiological condition. " 02/01/2005 - "Signaling events, including Rho GTPases and protein kinase C (PKC), are involved in cardiac hypertrophy. " 12/01/2010 - "The Rho guanosine triphosphatases (Rho GTPases) family, including RhoA, plays an important role in angiotensin II (Ang II)-mediated cardiac hypertrophy. "
3.	Pemphigus (Pemphigus Vulgaris) 05/01/2011 - "Role of Rho GTPases in desmosomal adhesion and pemphigus pathogenesis." 09/01/2007 - "Rather, the cleavage plane in intact human skin caused by pemphigus autoantibodies was similar to the plane of keratinocyte dissociation in response to toxin B-mediated inactivation of Rho GTPases. " 09/01/2010 - "Therefore, we investigated whether pharmacological manipulation of actin polymerization modulates pathogenic effects of PV-IgG. Pharmacological stabilization of actin filaments via jasplakinolide significantly blocked cell dissociation and Dsg3 fragmentation, whereas cytochalasin D-induced actin depolymerization strongly enhanced pathogenic effects of PV-IgG. To substantiate these findings, we studied whether the protective effects of Rho GTPases, which are potent regulators of the actin cytoskeleton and were shown to be involved in pemphigus pathogenesis, were dependent on modulation of actin dynamics. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2014 - "These results constitute a shift from the current paradigm and demonstrate that RHO GTPases can suppress tumour progression and metastasis. " 01/01/2014 - "Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis." 03/01/2013 - "The idea that autophagy is responsible for statin-induced anti-metastasis effects is probably novel, and it extends the conventional view that interference of the post-translational modification of Rho GTPases by statins prevents tumour metastasis." 02/16/2012 - "Our data indicate that interaction between Cav1 and Rho-GTPases (most likely RhoC but not RhoA) promotes metastasis by stimulating α5-integrin expression and regulating the Src-dependent activation of p130(Cas)/Rac1, FAK/Pyk2 and Ras/Erk1/2 signaling cascades." 01/01/2011 - "It is well established that the Rho family GTPases Rho, Rac and Cdc42 orchestrate many of the processes required during metastasis. "
5.	Breast Neoplasms (Breast Cancer) 05/08/2009 - "We also found that D4-GDI associates with Rac1 and Rac3 in breast cancer cells, but not with other Rho GTPases tested (Cdc42, RhoA, RhoC, and TC10). " 01/01/2008 - "Role of Rho GTPases in breast cancer." 06/01/2004 - "Here, we show that endogenous PAK is constitutively activated in certain breast cancer cell lines and that this active PAK is mislocalized to atypical focal adhesions in the absence of high levels of activated Rho GTPases. " 03/01/2004 - "Some Rho GTPases and their signaling components are overexpressed and/or are hyperactive in breast cancer and recent studies have shown a requirement for Rho GTPases in breast cancer cell metastasis in vivo. " 07/01/2014 - "Here, we identify a critical role for 14-3-3τ in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIα, a negative regulator of Rho GTPases and a metastasis suppressor. "

Related Drugs and Biologics

1.	GTP Phosphohydrolases (GTPases)
2.	Cytochalasin D
3.	Immunoglobulin G (IgG)
4.	jasplakinolide
5.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
6.	Proteins (Proteins, Gene)
7.	Cadherins (E-Cadherin)
8.	rho GTPase-activating protein
9.	Guanine
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Heterologous Transplantation (Xenotransplantation)