Leptin

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Also Known As:

Networked: 20156 relevant articles (829 outcomes, 3762 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mantzoros, Christos S: 102 articles (03/2022 - 03/2002)
2.	Myers, Martin G: 53 articles (01/2021 - 05/2003)
3.	Matarese, Giuseppe: 42 articles (01/2021 - 04/2002)
4.	Rahmouni, Kamal: 39 articles (01/2021 - 02/2002)
5.	Palou, Andreu: 37 articles (05/2022 - 07/2002)
6.	Gorden, Phillip: 37 articles (01/2018 - 02/2002)
7.	Hall, John E: 36 articles (01/2021 - 02/2002)
8.	Kalra, Satya P: 34 articles (01/2016 - 05/2002)
9.	Gertler, Arieh: 33 articles (01/2021 - 06/2005)
10.	Brown, Rebecca J: 32 articles (01/2022 - 09/2012)

Related Diseases

1.	Insulin Resistance 04/01/2005 - "We found no difference in cardiac indices, insulin resistance, body composition and leptin levels between patients with complete biochemical remission and those with inadequately controlled disease (P > 0.05 for all) after TSS. " 01/01/2022 - "Several significant correlations were found between insulin sensitivity indices, leptin, and serum metabolites identified as significantly different between remission and control cats. " 09/01/2017 - "Leptin correlated with improved insulin resistance (r = 0.449, p = 0.032) while reduced leptin showed a strong association with improved oxidative stress (r = 0.809, p = 0.001). " 12/01/2008 - "And the simultaneous measurement of insulin resistance and leptin concentration might be helpful for screening subjects with a high-risk of CAD." 01/01/2002 - "The surgical or pharmacological treatment of PA patients increased significantly their serum leptin levels (10.9+/-3.7 vs 8.4+/-1.9 ng/ml, P<0.05) and simultaneously improved their insulin sensitivity. "
2.	Obesity 01/01/2020 - "Thus, in an obesogenic environment, maintaining lower leptin levels is highly beneficial for both obesity and diabetes management. " 01/01/2021 - "Leptin plays an important role in the protection against diet-induced obesity (DIO) by its actions in ventromedial hypothalamic (VMH) neurons. " 04/18/2011 - "The interaction with leptin, which is thought to involve the hypothalamus, may have important implications for the development of new and improved hormonal anti-obesity treatments. " 01/11/2006 - "Absence of MCH neurons in ob/ob mice improved obesity, diabetes, and hepatic steatosis, suggesting that MCH neurons are important mediators of the response to leptin deficiency. " 04/01/2003 - "Changes in the biological efficacy of leptin were evaluated in obesity-resistant (A/J) and obesity-prone (C57BL/6J) mice at weaning and after consuming a high-fat (HF) diet for 4 and 8 wk. There was no evidence of leptin resistance in either strain at the start of the study, but after 4 and 8 wk on the HF diet, C57BL/6J mice became unresponsive to ip leptin. "
3.	Body Weight (Weight, Body) 01/01/2014 - "These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin. " 01/01/2013 - "Genetically obese females reared by lean dams showed normalized early levels of leptin and reduced body weight, food intake and body fat at adulthood; normalized estrous cycle structure and food intake across the cycle, improved hormonal profile and peripheral leptin sensitivity and a remarkable progress in self-control when exposed to a high fat/palatable diet. " 06/01/2005 - "Recent studies indicate that the passive range of motion exercise of the extremities results in a significantly greater increase of body weight, increased bone mineralization, increased bone formation markers and leptin levels, and attenuation of the natural post-natal decline in bone SOS. " 01/01/2020 - "We observed that E2 treatment was generally associated with significantly improved metabolic outcomes, including reductions in body weight, adiposity, and leptin, across both age groups. " 11/01/2019 - "At week 6, HFD + AA had significantly greater body fat % (12%), body weight (6%) and serum leptin concentrations (125%) than CTRL, whereas visceral fat (mass and %, assessed with micro-computed tomography) was increased in both HFD and HFD + AA groups. "
4.	Weight Loss (Weight Reduction) 05/01/1998 - "Exogenous administration of leptin to ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss. " 05/04/2007 - "Blocking central IL1 signaling also did not alter the re-feeding response to a prolonged fast, yet was entirely effective in preventing the anorexic effect of exogenously administered leptin (2 mg/kg ip, cumulative food intake at 18 h AdV-IL1ra 30.5+/-1.1 g vs. VEH 26.4+/-1.7 g, p<0.05) and prevented leptin-induced weight loss (AdV-IL1ra -0.1+/-1.3 g vs. VEH -2.7+/-1.9 g, p<0.05). " 01/01/2018 - "In such patients, leptin replacement results in substantial weight loss and improvement in peripheral metabolism. " 11/18/2016 - "The efficacy of the leptin/EX4 dual antibody fusion on weight loss, especially fat mass loss, was enhanced in ob/ob mice and DIO mice compared to the antibody fusion of either EX4 or leptin alone. " 12/01/2010 - "Weight loss (average 50% excess weight) was associated with a 14% improvement in PWV (P = 0.03), and with reductions in serum leptin levels (P < 0.01). "
5.	Inflammation (Inflammations) 04/01/2013 - "Kupffer cell depletion eliminated oxidative stress and inflammation, whereas in macrophage-depleted mice, the adoptive transfer of leptin-primed macrophages significantly restored inflammation. " 11/15/2003 - "The present study was designed to investigate the putative protective effects of CCK and leptin on acute colonic inflammation. " 01/01/2023 - "Leptin ameliorates Aβ1-42-induced AD by suppressing inflammation via activating the p-Akt signaling pathway." 01/01/2023 - "Studies have shown that the consumption of a high-fat diet (HFD) induces hypothalamic inflammation and leptin resistance, which consequently favours body mass gain. " 07/23/2022 - "Although there are studies concerning inflammation's influence on leptin secretion and vice versa, a ewe model, with its possible 'long-day leptin resistance', is still not examined enough. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Adiponectin
4.	Triglycerides (Triacylglycerol)
5.	Lipids
6.	Resistin
7.	Blood Glucose (Blood Sugar)
8.	Cholesterol
9.	Adipokines
10.	C-Reactive Protein

Related Therapies and Procedures

1.	Therapeutics
2.	Caloric Restriction
3.	Bariatric Surgery
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Injections