Experimental Nervous System Autoimmune Disease

Experimental animal models for human AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM. They include GUILLAIN-BARRE SYNDROME (see NEURITIS, AUTOIMMUNE, EXPERIMENTAL); MYASTHENIA GRAVIS (see MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL); and MULTIPLE SCLEROSIS (see ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL).

Also Known As:

Nervous System Autoimmune Disease, Experimental; Disease Models, Autoimmune, Nervous System; Experimental Autoimmune Myositis; Myositis, Autoimmune Experimental; Nervous System Autoimmune Disease Models; Autoimmune Experimental Myositis; Experimental Myositis, Autoimmune; Autoimmune Disease Models, Nervous System; Autoimmune Myositis, Experimental; Myositis, Experimental Autoimmune

Networked: 33 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Myositis (Idiopathic Inflammatory Myopathies)
2.	Polymyositis
3.	Mitochondrial Diseases (Mitochondrial Disease)
4.	Muscle Weakness
5.	Inflammation (Inflammations)

Experts

1.	He, Fangyuan: 3 articles (01/2022 - 01/2017)
2.	Jia, Hongge: 3 articles (01/2022 - 01/2017)
3.	Zhang, Hongya: 3 articles (01/2022 - 01/2017)
4.	Kang, Juan: 3 articles (07/2020 - 03/2012)
5.	Tian, Xiaojia: 3 articles (07/2020 - 01/2017)
6.	Allenbach, Yves: 3 articles (10/2017 - 03/2009)
7.	Benveniste, Olivier: 3 articles (10/2017 - 03/2009)
8.	Shi, Ming: 2 articles (01/2022 - 01/2017)
9.	Zhou, Linfu: 2 articles (01/2022 - 01/2017)
10.	Han, Wenjuan: 2 articles (07/2020 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Nervous System Autoimmune Disease:

1.	RetinoidsIBA 10/01/2009 - "Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo." 10/01/2009 - "The present study was undertaken to examine the effects of a synthetic retinoid, Am80, on experimental autoimmune myositis as well as on Th phenotype development and antibody production. " 10/01/2009 - "The synthetic retinoid Am80 has an inhibitory effect on experimental autoimmune myositis. "
2.	Myosins (Myosin)IBA 09/01/2017 - "In the present study, a myosin immunization protocol was applied to induce experimental autoimmune myositis (EAM) in guinea pigs. " 01/01/2018 - "Experimental autoimmune myositis (EAM) was induced in a total of 40 guinea pigs by myosin immunization. " 10/01/2009 - "Experimental autoimmune myositis was induced in SJL/J mice by immunization with rabbit myosin. " 11/15/2005 - "We induced experimental autoimmune myositis (EAM) in SJL/J mice by immunization with rabbit myosin and CFA. " 10/22/1997 - "Experimental autoimmune myositis (EAM) was induced in Lewis rats by immunization with partially purified and purified skeletal myosin. "
3.	Proteins (Proteins, Gene)FDA Link 09/15/2007 - "It has been demonstrated that immunization with native human skeletal C protein induces severe and reproducible experimental autoimmune myositis (EAM) in Lewis rats, and that the muscle inflammatory lesions in the EAM mimic those of human PM. " 10/01/2007 - "In the present study, we developed experimental autoimmune myositis (EAM) in Lewis rats by immunization with recombinant skeletal C-protein and examined the role of pathogenic T cells and autoantibodies. " 01/01/2020 - "Consistent with clinical data, the mRNA expression level of miR-146a also decreased, whereas the mRNA and protein level of REG3A, IFN-γ, and IL-17A significantly increased in the muscle tissues of experimental autoimmune myositis mice. " 03/01/2023 - "Classical murine models of autoimmune myositis, experimental autoimmune myositis, and C protein-induced myositis are established by immunization with muscle-specific antigens, myosin, and skeletal C protein, respectively. "
4.	NF-E2-Related Factor 2IBA 01/01/2019 - "We conducted this study to detect whether NF-E2-related factor 2 (Nrf2) pathway inhibit inflammatory infiltration by macrophage in experimental autoimmune myositis (EAM) rat model. "
5.	VenomsIBA 12/10/2015 - "We investigated the effect of defibrase (a proteolytic enzyme extraction of Agkistrodon halys venom) on experimental autoimmune myositis (EAM) in guinea pigs and explored the option of using a modified pig model of EAM to enhance the study of this disease. "
6.	BatroxobinIBA 12/10/2015 - "A new modified animal model of myosin-induced experimental autoimmune myositis enhanced by defibrase." 12/10/2015 - "We investigated the effect of defibrase (a proteolytic enzyme extraction of Agkistrodon halys venom) on experimental autoimmune myositis (EAM) in guinea pigs and explored the option of using a modified pig model of EAM to enhance the study of this disease. "
7.	Peptide Hydrolases (Proteases)FDA Link 12/10/2015 - "We investigated the effect of defibrase (a proteolytic enzyme extraction of Agkistrodon halys venom) on experimental autoimmune myositis (EAM) in guinea pigs and explored the option of using a modified pig model of EAM to enhance the study of this disease. "
8.	AutoantibodiesIBA 10/01/2007 - "In the present study, we developed experimental autoimmune myositis (EAM) in Lewis rats by immunization with recombinant skeletal C-protein and examined the role of pathogenic T cells and autoantibodies. "
9.	tamibaroteneIBA 10/01/2009 - "The present study was undertaken to examine the effects of a synthetic retinoid, Am80, on experimental autoimmune myositis as well as on Th phenotype development and antibody production. " 10/01/2009 - "The synthetic retinoid Am80 has an inhibitory effect on experimental autoimmune myositis. " 10/01/2009 - "In mice with experimental autoimmune myositis, orally administered Am80 significantly reduced the number of infiltrating inflammatory cells and the expression of tumor necrosis factor alpha and interleukin-1beta (IL-1beta) in muscle. " 10/01/2009 - "Moreover, Am80 increased production of interferon-gamma, IL-4, and IL-10, but not IL-17, by myosin-stimulated splenic T cells of mice with experimental autoimmune myositis, suggesting that it could enhance differentiation into Th1 and Th2, but not Th17, in vivo. "
10.	Interleukin-17 (Interleukin 17)IBA 01/01/2020 - "Consistent with clinical data, the mRNA expression level of miR-146a also decreased, whereas the mRNA and protein level of REG3A, IFN-γ, and IL-17A significantly increased in the muscle tissues of experimental autoimmune myositis mice. " 01/01/2017 - "Toll-Like Receptor 4-Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-γ and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model." 02/01/2017 - "[Tacrolimus down-regulates the mRNA levels of IL-17 and IL-23 in the muscle tissues of mice with experimental autoimmune myositis]." 02/01/2017 - "To measure the expression levels of interleukin-17( IL-17) and IL-23 mRNAs in the muscle tissue of the mice with experimental autoimmune myositis( EAM),and investigate the impact of tacrolimus( TAC) treatment on the mRNA levels of IL-17 and IL-23 and its therapeutic effect in EAM mice. " 10/01/2009 - "Moreover, Am80 increased production of interferon-gamma, IL-4, and IL-10, but not IL-17, by myosin-stimulated splenic T cells of mice with experimental autoimmune myositis, suggesting that it could enhance differentiation into Th1 and Th2, but not Th17, in vivo. "

Therapies and Procedures

1.	Subcutaneous Injections 12/18/2018 - "MATERIAL AND METHODS An experimental autoimmune myositis (EAM) model was built by subcutaneous injections of pertussis toxin (PTX) and purified rabbit myosin (10mg/kg) emulsified with an equal volume of conventional complete Freund's adjuvant (CFA) in a Lewis model. "