Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis)

Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Also Known As:
Autoimmune Experimental Myasthenia Gravis; Myasthenia Gravis, Autoimmune, Experimental; Experimental Autoimmune Myasthenia Gravis, Passive Transfer; Experimental Myasthenia; Experimental Myasthenia Gravis; Myasthenia Gravis, Autoimmune Experimental; Experimental Myasthenias; Myasthenia Gravis, Experimental; Myasthenia, Experimental; Myasthenias, Experimental; Myasthenia Gravis, Experimental Autoimmune; Passive Transfer Experimental Autoimmune Myasthenia Gravis
Networked: 436 relevant articles (16 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Myasthenia Gravis
2. Autoimmune Diseases (Autoimmune Disease)
3. Type 1 Diabetes Mellitus (Autoimmune Diabetes)
4. Muscle Weakness
5. Meningeal Carcinomatosis


1. Christadoss, Premkumar: 25 articles (04/2015 - 01/2002)
2. Tüzün, Erdem: 18 articles (04/2015 - 07/2002)
3. Fuchs, Sara: 17 articles (11/2014 - 02/2003)
4. Souroujon, Miriam C: 16 articles (11/2014 - 07/2003)
5. Feferman, Tali: 13 articles (12/2012 - 07/2003)
6. Duan, Rui-Sheng: 9 articles (08/2015 - 12/2002)
7. Saini, Shamsher S: 9 articles (05/2011 - 02/2006)
8. Yang, Huan: 9 articles (01/2008 - 07/2002)
9. Losen, Mario: 8 articles (08/2015 - 10/2005)
10. Sheng, Jian Rong: 7 articles (12/2015 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Autoimmune Myasthenia Gravis:
1. Acetylcholine (Acetylcholine Chloride)FDA Link
05/12/2014 - "Improved methodology to obtain large quantities of correctly folded recombinant N-terminal extracellular domain of the human muscle acetylcholine receptor for inducing experimental autoimmune myasthenia gravis in rats."
11/01/2010 - "In the current study, we investigated whether naturally occurring CD4(+)CD25(+) T cells, separated by immunomagnetic anti-CD4 and anti-CD25 Abs from naive animals, are able to protect from experimental autoimmune myasthenia gravis (EAMG) and modify the progression of ongoing disease when administered to Torpedo californica acetylcholine receptor (AChR)-immunized Lewis rats. "
06/01/1998 - "To study the involvement of B cells in the immune response to acetylcholine receptor (AChR), B-cell-deficient (mu mutant) and control wild-type C57BL/6 mice were immunized with AChR and assessed for clinical and immunopathological manifestations of experimental autoimmune myasthenia gravis (EAMG). "
05/15/1995 - "Previous study has shown that reduced T cell response to peptide alpha 146-162 of Torpedo californica acetylcholine receptor (tAChR) in B6.C-H-2bm12 (bm12) mice, a mutant of C57BL/6 (B6) mice, correlated with its nonsusceptiblity to experimental autoimmune myasthenia gravis. "
03/01/1995 - "The overall goal of this study was to determine, during induction of experimental autoimmune myasthenia gravis (EAMG) in Lewis rats, the relative importance of acetylcholine receptor (AChR)-reactive helper T cells associated with one particular immunodominant fine specificity. "
2. AutoantibodiesIBA
3. Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
4. Immunosuppressive Agents (Immunosuppressants)IBA
5. Cholinesterase Inhibitors (Anticholinesterases)IBA
6. Chaperonin 60IBA
7. Interleukin-9 (Interleukin 9)IBA
8. Peptide FragmentsIBA
9. Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
10. PeptidesIBA

Therapies and Procedures

1. Intraperitoneal Injections
2. Lymphatic Irradiation
3. Immunotherapy
4. Immunomodulation
5. Thymectomy