Glucuronides

Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.

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Networked: 795 relevant articles (39 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Papot, Sébastien: 9 articles (11/2020 - 02/2007)
2.	Cheng, Tian-Lu: 9 articles (11/2017 - 05/2006)
3.	Roffler, Steve R: 9 articles (04/2016 - 05/2006)
4.	Hu, Ming: 8 articles (12/2018 - 04/2008)
5.	Hecht, Stephen S: 8 articles (08/2015 - 04/2005)
6.	Renoux, Brigitte: 7 articles (11/2020 - 04/2010)
7.	Gonzalez, Frank J: 6 articles (01/2019 - 08/2013)
8.	Chen, Kai-Chuan: 6 articles (04/2016 - 04/2009)
9.	Wu, Baojian: 5 articles (03/2018 - 02/2012)
10.	Carmella, Steven G: 5 articles (08/2015 - 03/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Long considered as no more than biological waste meant to be eliminated in urine, glucuronides have recently contributed to tremendous developments in the biomedical field, particularly against cancer. " 06/01/1997 - "Nevertheless, in vitro studies carried out by various investigators have shown that the cytotoxicities of several glucuronides in cancer cells are not sufficiently high for their use as effective anti-cancer drugs. " 01/01/2022 - "Here we will discuss some of the most promising strategies using glucuronides to promote successful anti-tumor therapeutic treatments." 01/01/2022 - "In both cases, glucuronides are utilized as a vector to improve pharmacokinetics and confer localized activation of potent drugs at tumor sites while also decreasing systemic toxicity. " 01/01/2020 - "Each of these points is highly significant and together afford a safe, selective anticancer measure, making tumor-targeted glucuronides attractive for translational medicine."
2.	Renal Insufficiency (Renal Failure) 04/01/1994 - "The pharmacokinetics of the drug in patients with renal failure have not been published, and may be important because the acyl-glucuronides are renally cleared." 01/01/2022 - "In the case of advanced renal failure, the glucuronides accumulate, mainly responsible for toxicity 3-glucuronides. " 01/01/2012 - "2) Although the renal excretion rate of acetoaminophen is only less than 5%, the accumulation of its glucuronide conjugate during multiple dosing in patients with kidney failure may induce high serum acetoaminophen trough levels via the entero-hepatic circulation. " 01/01/1982 - "Glucuronidation and disposition of drug glucuronides in patients with renal failure. " 01/01/1981 - "Higher post-hydrolysis values confirmed the presence of glucuronides in plasma from normal subjects and patients with renal failure. "
3.	Inflammation (Inflammations) 01/01/2020 - "The bioactivity of flavonoid glucuronides and free aglycones in the context of their absorption, II phase metabolism and deconjugation at the inflammation site." 10/08/2008 - "Although metabolic conversion attenuates its biological effects, active aglycone may be generated from the glucuronide conjugates by enhanced beta-glucuronidase activity during inflammation. " 01/01/2005 - "These results suggest that beta-glucuronidase released from neutrophils or certain injured cells may hydrolyze glucuronide conjugates to free aglycones at the site of inflammation." 01/01/2005 - "We investigated whether glucuronides were converted to free parent compounds by beta-glucuronidase released from human-stimulated neutrophils in inflammation. " 11/01/2021 - "Curcumin exerts protective metabolic effects in dietary obesity, in part through downregulation of adipose tissue inflammation, which may be mediated by alterations in composition of gut microbiota, and metabolism of curcumin into curcumin-O-glucuronide."
4.	Breast Neoplasms (Breast Cancer) 12/01/2014 - "We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case-control study conducted in two cities in Poland (2000-2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population. " 04/01/2016 - "Bioanalytical LC-MS Method for the Quantification of Plasma Androgens and Androgen Glucuronides in Breast Cancer." 11/01/2012 - "The efflux transporter breast cancer resistance protein (BCRP/ABCG2) plays an important role in excretion of anionic drugs and metabolites including glucuronides in humans. " 11/01/2012 - "A new strategy to rapidly evaluate kinetics of glucuronide efflux by breast cancer resistance protein (BCRP/ABCG2)." 12/01/2010 - "Hydroxyanastrozole (mainly as a glucuronide) and anastrozole were quantified in plasma of breast cancer patients taking anastrozole (1 mg day⁻¹); anastrozole glucuronide was less apparent. "
5.	Cholestasis 03/01/2008 - "In this study we examined the interactions of some therapeutic agents, which have been shown to cause cholestasis, with the elimination of bilirubin-glucuronides, in order to clarify whether these drugs modify the activity of Mrp2 and Mrp3 directly. " 04/01/2018 - "We characterized this process in estradiol 17 β-d-glucuronide (E17G)-induced cholestasis, an experimental model which partially mimics pregnancy-induced cholestasis. " 09/01/2009 - "Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis." 09/01/2005 - "Due to cholestasis or adverse drug effects, the excretion of bilirubin conjugates can decrease; therefore, the level of bilirubin (B) and bilirubin glucuronides (BGs) increases in the serum with the concomitant shift of bilirubin diversus monoglucuronide (BDG/BMG) equilibrium. " 10/01/1998 - "Male Sprague-Dawley rats were given a single oral dose of 150 mg/kg ANIT or i.v. doses of estradiol glucuronide (E2-17G; 21 mumol/kg/h for 48 h) to produce obstructive and non-obstructive cholestasis, respectively. "

Related Drugs and Biologics

1.	Prodrugs
2.	Glucuronidase
3.	Mycophenolic Acid (Cellcept)
4.	Sulfates (Sulfates, Inorganic)
5.	Proteins (Proteins, Gene)
6.	Acetaminophen (Paracetamol)
7.	baicalin
8.	Morphine (MS Contin)
9.	Enzymes
10.	Androgens

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Peritoneal Dialysis
4.	Drug Therapy (Chemotherapy)
5.	Drug Substitution