RGS Proteins

A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.

Also Known As:

Networked: 82 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hooks, Shelley B: 7 articles (01/2018 - 01/2008)
2.	Neubig, Richard R: 7 articles (06/2015 - 03/2002)
3.	Traynor, John R: 6 articles (01/2020 - 07/2004)
4.	Druey, Kirk M: 5 articles (01/2021 - 08/2003)
5.	Hurst, Jillian H: 4 articles (11/2010 - 02/2008)
6.	Yang, Shuying: 3 articles (01/2022 - 03/2013)
7.	Fisher, Rory A: 3 articles (12/2020 - 01/2012)
8.	Huang, Xinyan: 3 articles (06/2010 - 05/2007)
9.	Roman, David L: 2 articles (12/2019 - 01/2016)
10.	Martemyanov, Kirill A: 2 articles (04/2016 - 08/2013)

Related Diseases

1.	Hypertrophy 03/03/2006 - "In this study, we report a marked decrease in RGS2 (but not other major cardiac RGS proteins (RGS3-RGS5)) that occurs prior to hypertrophy development in different models with enhanced G(q/11) signaling (transgenic expression of activated Galpha(q)(*) and pressure overload due to aortic constriction). " 10/01/2006 - "We investigated the potential role of RGS proteins on alpha1-adrenergic receptor signals associated with hypertrophy in primary cultures of neonatal rat cardiomyocytes. " 05/01/2004 - "This article reviews the role of G alpha q in the development of pressure overload hypertrophy and discusses the relationships between G alpha q and beta-adrenergic receptors, RGS proteins, and the proapoptotic factor, Nix/Bnip3L."
2.	Neoplasms (Cancer) 09/15/2004 - "These data provide the first evidence that RGS proteins may be important modulators of cancer risk and validate RGS6 as a target for further study." 04/28/2023 - "In this review, we summarize the molecular mechanisms governing the expression of RGS proteins, and further discuss the relationship of RGS proteins and cancer." 04/28/2023 - "Emerging evidence has shown that RGS proteins act as important mediators in controlling essential cellular processes including cell proliferation, survival -and death via regulating downstream cellular signaling activities, indicating that RGS proteins are fundamentally involved in sustaining normal physiological functions and dysregulation of RGS proteins (such as aberrant expression of RGS proteins) is closely associated with pathologies of many diseases such as cancer. " 04/28/2023 - "RGS proteins and their roles in cancer: friend or foe?" 01/01/2023 - "We used the novel bioinformatics tool three-dimensional missense tolerance ratio (3DMTR) to define regions of genetic intolerance in RGS proteins and prioritize which cancer-linked mutants to test. "
3.	Carcinogenesis 09/15/2004 - "Recent reports have shown that RGS proteins modulate neuronal, cardiovascular, and lymphocytic activity, yet their role in carcinogenesis has not been explored. " 01/01/2019 - "Many studies have shown that RGS proteins contribute to tumorigenesis and metastasis. " 11/15/2009 - "This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types."
4.	Parkinson Disease (Parkinson's Disease) 10/01/2003 - "In connection with the previously documented acute regulation of RGS proteins after modulation of the dopaminergic transmission [Geurts et al., Neurosci Lett 2002;333:146-50], the present study demonstrates that alteration in their genetic expression can be long-lasting and this could reflect the adaptation processes that occur in certain pathological states, such as Parkinson's disease." 12/01/2020 - "RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson's Disease." 06/17/2015 - "These results expand our understanding of the mechanism and specificity of TDZD RGS inhibitors and support the potential for therapeutic targeting of RGS proteins in Parkinson's disease and other neural disorders. " 06/17/2015 - "Regulators of G protein signaling (RGS) proteins, especially RGS4, play significant roles in epilepsy and Parkinson's disease. " 10/01/2014 - "Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of l-DOPA-induced abnormal involuntary movements (AIMs), also known as dyskinesia (LID), in Parkinson's disease (PD). "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2009 - "Thus, multiple RGS proteins are expressed at significantly different levels in cells derived from cancerous and normal ovarian cells and at least two candidate RGS transcripts have been identified to account for the reported regulation of LPA signalling pathways in ovarian cancer cells." 01/01/2009 - "We have recently reported that RGS proteins endogenously expressed in SKOV-3 ovarian cancer cells dramatically attenuate LPA stimulated cell signalling. " 02/01/2008 - "These data establish RGS proteins as novel regulators of LPA signaling in ovarian cancer cells." 02/01/2008 - "Finally, LPA-stimulated SKOV-3 cell migration, as measured in a wound-induced migration assay, was enhanced in cells expressing Galpha(i2) RGSi as compared to cells expressing Galpha(i2) RGSwt, suggesting that endogenous RGS proteins in ovarian cancer cells normally attenuate this LPA effect. " 02/01/2008 - "To determine the effect of endogenous RGS proteins on LPA signaling in ovarian cancer cells, we compared LPA activity in SKOV-3 ovarian cancer cells expressing G(i) subunit constructs that are either insensitive to RGS protein regulation (RGSi) or their RGS wild-type (RGSwt) counterparts. "

Related Drugs and Biologics

1.	GTP-Binding Proteins (G-Protein)
2.	Proteins (Proteins, Gene)
3.	Opioid Analgesics (Opioids)
4.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
5.	mu Opioid Receptors (mu Opioid Receptor)
6.	Pertussis Toxin
7.	GTPase-Activating Proteins (GTPase-Activating Protein)
8.	GTP Phosphohydrolases (GTPases)
9.	Opioid Receptors (Opioid Receptor)
10.	lysophosphatidic acid

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Analgesia