rab GTP-Binding Proteins

A large family of MONOMERIC GTP-BINDING PROTEINS that play a key role in cellular secretory and endocytic pathways.

Also Known As:

G-Proteins, rab; GTP-Binding Protein, rab; GTP-Binding Proteins, rab; GTPase, Rab; GTPases, rab; Protein, rab GTP-Binding; rab G Proteins; rab GTP Binding Protein; rab GTP Binding Proteins; Rab GTPase; rab G-Proteins; rab GTP-Binding Protein; rab GTPases

Networked: 180 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alessi, Dario R: 6 articles (01/2020 - 01/2016)
2.	Pfeffer, Suzanne R: 4 articles (12/2019 - 11/2017)
3.	Tonelli, Francesca: 4 articles (11/2018 - 01/2016)
4.	Khan, Amir R: 3 articles (01/2021 - 01/2020)
5.	Purlyte, Elena: 3 articles (01/2021 - 01/2018)
6.	Lis, Pawel: 3 articles (12/2019 - 11/2017)
7.	Dhekne, Herschel S: 3 articles (11/2018 - 11/2017)
8.	Steger, Martin: 3 articles (11/2018 - 01/2016)
9.	Goud, Bruno: 3 articles (08/2015 - 03/2010)
10.	Wan, Ying: 3 articles (04/2015 - 10/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/14/2020 - "Collectively, we evidence, for the first time, that AIR breast cancer cells display an increased capability to release exosomes, which may be associated with an enhanced Rab GTPase expression. " 01/01/2016 - "Through a functional siRNA screening of human RAB GTPases, we found that RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines. " 03/01/2020 - "The literature for this review was mainly searched in PubMed during the years 2014 to 2018 by using the keywords, 'breast cancer', 'breast cancer and its current treatments', 'breast cancer and vesicular trafficking', 'Rab family proteins in breast cancer', etc. Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer."
2.	Neoplasms (Cancer) 01/01/2023 - "Recent studies have reported that some Rab GTPases are involved in multiple aspects of tumor progression, including invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. " 01/01/2022 - "RAB6B is a member of Rab GTPases, and it has been found to be dysregulated in various tumors. " 01/01/2021 - "Finally, we discuss the clinical implications and the potential as a cancer therapeutic target of Rab GTPases." 01/01/2021 - "In this review, we describe the characteristics of Rab GTPases; in particular, we discuss the role of their activation in the regulation of membrane transport and provide examples of Rab GTPases regulating membrane transport in tumor progression. " 01/01/2021 - "Therefore, targeting Rab GTPases to adjust membrane trafficking has the potential to become a novel way to adjust cancer treatment. "
3.	Infections 12/01/2023 - "Rab32 is a member of the Rab GTPase family that is involved in membrane trafficking and immune response, which are crucial for controlling pathogen infection. " 01/01/2022 - "However, the relationship between exosomes and Rab GTPases, resulting in antimicrobial activity in vertebrates and invertebrates during pathogenic infection, has not been addressed. " 01/01/2021 - "The role of host cell Rab GTPases in influenza A virus infections." 01/01/2019 - "Chlamydia trachomatis CT229 Subverts Rab GTPase-Dependent CCV Trafficking Pathways to Promote Chlamydial Infection." 05/01/2018 - "Role of Rab GTPases in HSV-1 infection: Molecular understanding of viral maturation and egress."
4.	Virus Diseases (Viral Diseases) 01/01/2008 - "However, the role of Rab GTPases in phagocytosis against virus infection remains unknown. " 08/01/2007 - "Characterization of a Rab GTPase up-regulated in the shrimp Peneaus japonicus by virus infection." 01/01/2008 - "Therefore, our study presents a novel Rab-dependent signaling complex, in which the Rab GTPase might detect virus infection as an intracellular virus recognition protein and trigger downstream phagocytic defense against virus in crustacean for the first time. " 01/01/2023 - "In addition, functional enrichment analysis of genes with RNA editing highlighted that the Rab GTPase family played a common and vital role in the host immune response to IBP and ssRNA viral infections, which was indicated by the consistent up-regulated RNA editing of Ras-related protein Rab27a. "
5.	Lung Neoplasms (Lung Cancer) 06/01/2021 - "In this study, using a combination of molecular, biochemical, and imaging approaches, we discovered that in colon and lung cancer, upon ER stress, ER chaperones, such as GRP78 bypass the Golgi and unconventionally traffic to the cell surface via endosomal transport mediated by Rab GTPases (Rab4, 11 and 15). " 01/01/2020 - "We found that microRNAs target Rab GTPases to regulate EV release from lung cancer cell lines. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Transcription Factors (Transcription Factor)
3.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
4.	Monomeric GTP-Binding Proteins
5.	Lipids
6.	Glucose (Dextrose)
7.	Angiotensin II
8.	Endoplasmic Reticulum Chaperone BiP
9.	TRAPP transport protein particle
10.	LIDA

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy