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Cefixime (Suprax)

A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.

Also Known As:

Suprax; FK 027; FK-027; FR-17027; 027, FK; FK027; FR 17027; FR17027; 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)((carboxymethoxy)imino)acetyl)amino)3-ethenyl-8-oxo-, trihydrate, (6R-(6alpha,7beta(Z)))-

Networked: 308 relevant articles (69 outcomes, 83 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Centers for Disease Control and Prevention (CDC): 4 articles (08/2012 - 11/2002)
2.	Deguchi, Takashi: 4 articles (09/2010 - 03/2003)
3.	Yasuda, Mitsuru: 4 articles (09/2010 - 03/2003)
4.	Ison, Catherine A: 3 articles (01/2015 - 09/2013)
5.	Town, Katy: 3 articles (01/2015 - 09/2013)
6.	Unemo, Magnus: 3 articles (12/2014 - 03/2012)
7.	Craig, J C: 3 articles (01/2007 - 01/2003)
8.	Hodson, E M: 3 articles (01/2007 - 01/2003)
9.	Kidd, Sarah: 2 articles (12/2015 - 12/2013)
10.	GRASP collaborative group: 2 articles (01/2015 - 09/2013)

Related Diseases

1.	Infection 03/01/2003 - "This regimen would not be effective against infection by strains exhibiting cefixime MIC(90)s of > or =0.125 microg/ml. For such strains, a different regimen with a higher dose of cefixime would be required." 10/01/1986 - "gonorrhoeae infections, and cefixime shows considerable promise for treatment of N. " 03/01/1993 - "Cefixime was effective in the treatment of bacterial sinus infections in adults and was well tolerated." 01/01/2015 - "This study demonstrated that of the previous first-line therapies, cefixime would be the only antimicrobial suitable for use for infection in heterosexual patients alone." 09/01/1998 - "Preliminary studies have shown excellent clinical outcomes with switch therapy to cefixime after 2-3 days for a variety of serious infections. "
2.	Otitis Media 03/01/1994 - "The results of this study support the daily administration of cefixime as an effective agent for the treatment of otitis media due to its extended half-life and broad antibiotic spectrum." 01/01/1991 - "The results of this study demonstrate that cefixime is an effective and well tolerated treatment for acute otitis media in children." 01/01/1991 - "It was concluded that cefixime is clinically effective and well tolerated in the treatment of children with acute otitis media." 03/01/1994 - "An experimental study of cefixime in the treatment of Streptococcus pneumoniae otitis media." 01/01/1991 - "A large scale multicentre clinical study was undertaken to assess the efficacy and tolerability of cefixime in the treatment of acute otitis media in children. "
3.	Urinary Tract Infections (Urinary Tract Infection) 02/01/1995 - "Cefixime given per os seems effective and safe in treating urinary tract infections. " 10/11/1989 - "Cefixime is a safe and effective antibiotic for the treatment of urinary tract infections." 10/11/1989 - "Thousands of adults have been treated by cefixime for lower respiratory tract, ear-nose-throat and urinary tract infections, showing that cefixime is a safe and effective antimicrobial agent. " 12/01/2011 - "The present study was designed to assess the clinical efficacy, bacteriological eradication rates and tolerability of cefixime in children with community-acquired upper RTI (URTI), lower RTI (LRTI) and uncomplicated urinary tract infections (UTI). " 03/01/2003 - "Cefixime for the prophylaxis of urinary tract infections in children with malformative uropathies: an open study."
4.	Respiratory Tract Infections (Respiratory Tract Infection) 09/01/1998 - "Very good efficacy of cefixime was also demonstrated microbiologically, with eradication in 35 of 36 isolates from children, including all Streptococcus pneumoniae isolates, 40 of 45 isolates from patients with respiratory tract infections, and 64 of 71 isolates from patients with UTI." 09/16/1988 - "Results of these trials demonstrate that cefixime at a dosage of 400 mg once daily is an effective and safe oral antibiotic for the treatment of acute respiratory tract infections." 10/11/1989 - "Administered in doses of 200 mg twice daily, cefixime proved effective and safe in the treatment of lower respiratory tract infections." 01/01/1995 - "Safety and efficacy of cefixime in treatment of respiratory tract infections in Germany." 05/01/1996 - "Cefixime in the treatment of patients with lower respiratory tract infections: results of US clinical trials."
5.	Typhoid Fever (Typhoid) 09/01/2001 - "However, cefixime has been shown to be clinically effective against typhoid fever. " 12/01/1995 - "Cefixime given in a short 8-day course is safe and effective in the management of MDR typhoid fever in children." 01/01/2000 - "Efficacy of cefixime in the therapy of typhoid fever." 12/01/1997 - "This study is meant to assess the efficacy, safety, and cost effectiveness of an oral third-generation cephalosporin (cefixime) in the treatment of multidrug-resistant enteric fever. " 09/01/2008 - "Salmonella paratyphoid A, for which there is no commercial vaccine, may not be a benign disease as perceived, and cefixime that is recommended for enteric fever may be an ineffective choice."

Related Drugs and Biologics

1.	Amoxicillin (Wymox)
2.	Ceftriaxone (Ceftriaxon)
3.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
4.	Cefixime (Suprax)
5.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)
6.	Ciprofloxacin (Cipro)
7.	Cephalosporins (Cephalosporin Antibiotics)
8.	Cefaclor (Ceclor)
9.	Azithromycin (Zithromax)
10.	Clavulanic Acid (Potassium Clavulanate)

Related Therapies and Procedures

1.	Oral Administration
2.	Catheters
3.	Off-Label Use
4.	Kampo Medicine (Kampo)
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)