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Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)

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Cellular DNA-binding proteins encoded by the sis gene (GENES, SIS). c-sis proteins make up the B chain of PLATELET-DERIVED GROWTH FACTOR. Overexpression of c-sis causes tumorigenesis.

Also Known As:

Platelet Derived Growth Factor B; Proto-Oncogene Products c-sis; Proto-Oncogene Protein sis; Proto-Oncogene Proteins sis; Proto Oncogene Products c sis; Proto Oncogene Protein sis; Proto Oncogene Proteins c sis; Proto Oncogene Proteins sis; Proto-Oncogene Proteins, sis; c sis Proteins; sis Proto Oncogene Proteins; sis, Proto-Oncogene Protein; sis, Proto-Oncogene Proteins; PDGFB; Platelet-Derived Growth Factor B; c-sis Proteins; sis Proto-Oncogene Proteins

Networked: 269 relevant articles (3 outcomes, 27 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Betsholtz, Christer: 8 articles (01/2015 - 08/2002)
2.	Fuller, Gregory N: 7 articles (05/2015 - 07/2007)
3.	Rao, Ganesh: 5 articles (05/2015 - 12/2010)
4.	Holland, Eric C: 5 articles (10/2014 - 07/2004)
5.	Uhrbom, Lene: 5 articles (10/2014 - 09/2007)
6.	Westermark, Bengt: 5 articles (06/2011 - 06/2005)
7.	Yang, Yuhui: 4 articles (05/2015 - 11/2011)
8.	Zhang, Wei: 4 articles (03/2015 - 07/2007)
9.	Pedeutour, Florence: 4 articles (02/2015 - 04/2002)
10.	Uhrbom, L: 4 articles (06/2009 - 02/2000)

Related Diseases

1.	Wounds and Injuries (Trauma) 09/01/1999 - "Adenoviral-mediated gene transfer of platelet-derived growth factor-B overcame the ischemic defect in wound healing and offers promise in the treatment of chronic nonhealing wounds. " 02/01/2009 - "To investigate the biological function of platelet-derived growth factor B (PDGF-B) on the survival and proliferation of cat corneal endothelial cells so as to provide bases for further studies of its role in wound repair and its clinical application. " 07/01/2005 - "In this study, lentiviral vectors carrying the human platelet-derived growth factor B (PDGF-B) gene were used to treated diabetic mouse wounds. " 10/01/2003 - "In this study, mouse dermal fibroblasts retrovirally transduced with the human platelet-derived growth factor B (PDGF-B) gene were used to treat diabetic mouse wounds. " 05/01/2009 - "Clinical interest has been witnessed in the past for exogenous applications of platelet derived growth factor B (PDGF-B) in chronic nonhealing wounds. "
2.	Glioma (Gliomas) 12/01/2012 - "(18)F-SKI249380 is a PDGFR-selective tracer, which demonstrates improved delivery to PDGFB-driven high-grade gliomas and facilitates treatment planning when coupled with nanoformulations and quantitative PET imaging approaches." 07/10/2007 - "Thus, this study provides definitive evidence that IGFBP2 plays a key role in activation of the Akt pathway and collaborates with K-Ras or PDGFB in the development and progression of two major types of glioma." 05/01/2015 - "We showed that coexpression of STAT5b and PDGFB in mice yielded a significantly higher rate of high-grade gliomas than PDGFB expression alone. " 07/01/2014 - "Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H." 01/01/2013 - "The phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma, and Lrig2 appeared to have important molecular and developmental functions that were distinct from those of Lrig1 and Lrig3."
3.	Neoplasms (Cancer) 02/01/2008 - "Thus, Pdgfb-iCreER mice are a valuable research tool to manipulate endothelial cells in postnatal mice and study tumor angiogenesis." 01/15/1994 - "Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study." 10/01/2015 - "We generated subcutaneous tumors in a genetic mouse model of pericyte deficiency (the pdgfb (ret/ret) mouse) and littermate control mice (n = 6-25). " 05/01/2015 - "High-grade tumors from the STAT5b + PDGFB expression set were found to have a lower rate of apoptosis than those from PDGFB alone. " 02/01/2015 - "For the 185 certain tumors specimens: 178 (96%) FISH analyses showed a PDGFB/COL1A1 rearrangement, 7 (4%) were negative. "
4.	Breast Neoplasms (Breast Cancer) 05/03/2013 - "In the present study, we found that both HBXIP and PDGFB were highly expressed in breast cancer cell lines. " 05/03/2013 - "In function, HBXIP enhanced the proliferation of breast cancer cells through PDGFB in vitro. " 10/02/2012 - "In this study, we show that HIF-1 promotes lymphatic metastasis of breast cancer by direct transactivation of the gene encoding platelet-derived growth factor B (PDGF-B), which has proliferative and chemotactic effects on lymphatic endothelial cells. " 05/03/2013 - "Thus, we conclude that HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells." 05/03/2013 - "The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast cancer cells."
5.	Ischemia 05/01/1998 - "The present study was conducted to clarify the role of platelet-derived growth factor-B chain (PDGF-B) in neuronal death after ischemia. " 09/01/1994 - "Ischemia induces the expression of the platelet-derived growth factor-B chain in neurons and brain macrophages in vivo." 02/16/1998 - "To investigate whether the homodimer of platelet-derived growth factor B-chain (PDGF-BB) can protect neurons against focal temporary ischemia, PDGF-BB was administered to the rat brain for a prolonged period prior to, during, and after ischemia, since PDGF-BB protected rat neurons from global ischemia in our previous study. " 01/06/2006 - "Using a severe hindlimb ischemia model of streptozotocin-induced diabetic mice (STZ-DM), we show that diabetic foot is a disease solely of the disturbance of platelet-derived growth factor B-chain homodimer (PDGF-BB) expression but not responses of angiogenic factors. "

Related Drugs and Biologics

1.	Collagen
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
4.	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)
5.	Interleukin-1beta (Interleukin 1 beta)
6.	Fibronectins (Fibronectin)
7.	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)
8.	Platelet-Derived Growth Factor
9.	Dermatofibrosarcoma protuberans
10.	platelet-derived growth factor BB (becaplermin)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Microbubbles
3.	Transplantation (Transplant Recipients)
4.	Traction
5.	Therapeutics