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Monomeric GTP-Binding Proteins

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A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 3.6.1.47

Also Known As:

ras-Related G-Proteins; ras-Related GTP-Binding Proteins; G Proteins, Monomeric; G-Proteins, Small; G-Proteins, ras-Related; GTP Binding Proteins, Monomeric; GTP-Binding Proteins, ras-Related; GTPases, Small; GTPases, ras-Related; Monomeric G Proteins; Monomeric GTP Binding Proteins; Proteins, ras-Related GTP-Binding; Small G Proteins; ras Related G Proteins; ras Related GTP Binding Proteins; ras Related GTPases; G-Proteins, Monomeric; GTP-Binding Proteins, Monomeric; Monomeric G-Proteins; Small G-Proteins; Small GTPases; ras-Related GTPases

Networked: 286 relevant articles (4 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Der, Channing J: 11 articles (09/2015 - 11/2007)
2.	Theodorescu, Dan: 8 articles (12/2012 - 01/2003)
3.	Martin, Timothy D: 6 articles (09/2015 - 09/2010)
4.	Zheng, Yi: 5 articles (05/2015 - 04/2003)
5.	Wang, En-Hua: 4 articles (02/2015 - 03/2009)
6.	Zhang, Jun-Yi: 4 articles (02/2015 - 03/2009)
7.	Symons, Marc: 4 articles (02/2014 - 11/2005)
8.	Williams, Carol L: 4 articles (01/2014 - 01/2008)
9.	Lorimer, Ellen L: 4 articles (01/2014 - 01/2008)
10.	Oxford, Gary: 4 articles (07/2007 - 01/2003)

Related Diseases

1.	Infection 04/01/2007 - "The aim of the present study was to examine, at earlier stages of infection, the distribution and roles of the small GTPases Rab5 and Rab7, markers of early and late endosomes respectively, as well as of the protein LC3 on C. " 01/01/2005 - "In short, the high expression of immuno-related genes in response to the virus infection and the involvement of small GTPases in the antiviral response provide a new insight for further study in the crustacean innate immunity." 08/01/2012 - "Here we identified the small GTPases Rab9A and Rab23 as novel autophagy regulators during Group A streptococcus (GAS) infection. " 08/01/2012 - "The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection." 04/01/2010 - "Subversion of Rho family small GTPases, which control actin dynamics, is a common infection strategy used by bacterial pathogens. "
2.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2011 - "Statins were found to exert protective effects on cardiovascular disease by suppressing activation of small G proteins, independently of their lipid-lowering effect. " 10/01/2013 - "Pharmacological modulation of small GTPases in cardiovascular diseases: from statins to selective inhibitors."
3.	Lung Injury 01/01/2008 - "Besides blunting the Toll-like receptor-4-induced inflammatory cascade and lung dysfunction in a model of lipopolysaccharide-induced lung injury, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) exerts direct barrier-protective effects on pulmonary endothelial cells in vitro via activation of the small GTPases Rac and Cdc42. "
4.	Heart Diseases (Heart Disease) 01/01/2011 - "Understanding the crosstalk between small G proteins and LTCC may help to understand the pathomechanism of different cardiac diseases and to develop a new generation of genetically-encoded Ca(2+ ) channel inhibitors."
5.	Neoplasms (Cancer) 01/01/2014 - "In the current study, we focused on the role of microenvironment generated by exercise and metastasizing tumor cells at the levels of brain microvessels, influencing oxidative stress-mediated responses and activation of redox-sensitive small GTPases. " 11/01/2004 - "Overall, these studies implicate RAB25, and thus the RAB family of small G proteins, in aggressiveness of epithelial cancers." 09/11/2015 - "The Ras-like small GTPases RalA and RalB are well validated effectors of RAS oncogene-driven human cancer growth, and pharmacologic inhibitors of Ral function may provide an effective anti-Ras therapeutic strategy. " 05/15/2015 - "The Ras family small GTPases regulate multiple cellular processes, including cell growth, survival, movement, and gene expression, and are intimately involved in cancer pathogenesis. " 07/31/2014 - "The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been implicated in cancer and other human diseases. "

Related Drugs and Biologics

1.	Nitrogen
2.	oxidized- L- alpha- 1- palmitoyl- 2- arachidonoyl- sn- glycero- 3- phosphorylcholine
3.	Cadherins (E-Cadherin)
4.	Transforming Growth Factor beta (TGF-beta)
5.	Proteins (Proteins, Gene)
6.	GTP Phosphohydrolases (GTPases)
7.	p21-Activated Kinases
8.	Terpenes (Terpenoids)
9.	NF-kappa B (NF-kB)
10.	Mevalonic Acid (Mevalonate)

Related Therapies and Procedures

1.	Chemoprevention
2.	Heterologous Transplantation (Xenotransplantation)