Small Nucleolar RNA (snoRNA)

Small nuclear RNAs that are involved in the processing of pre-ribosomal RNA in the nucleolus. Box C/D containing snoRNAs (U14, U15, U16, U20, U21 and U24-U63) direct site-specific methylation of various ribose moieties. Box H/ACA containing snoRNAs (E2, E3, U19, U23, and U64-U72) direct the conversion of specific uridines to pseudouridine. Site-specific cleavages resulting in the mature ribosomal RNAs are directed by snoRNAs U3, U8, U14, U22 and the snoRNA components of RNase MRP and RNase P.

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Networked: 785 relevant articles (4 outcomes, 147 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jiang, Feng: 7 articles (02/2019 - 07/2010)
2.	Wang, Li: 5 articles (10/2022 - 05/2015)
3.	Wang, Jing: 5 articles (08/2022 - 01/2020)
4.	Chu, Liang: 5 articles (01/2022 - 08/2012)
5.	Yuan, Yufeng: 5 articles (11/2021 - 12/2016)
6.	Zhang, Li: 5 articles (11/2021 - 10/2018)
7.	Zhang, Hui: 5 articles (10/2021 - 12/2016)
8.	Liu, Xin: 4 articles (07/2022 - 11/2019)
9.	Zhang, Hao: 4 articles (02/2022 - 01/2020)
10.	Zhang, Rui: 4 articles (01/2022 - 12/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In this study, we found that the H/ACA snoRNA SNORA24 was upregulated in various cancers, including CRC. " 01/01/2021 - "The present study identified a novel eleven-snoRNA prognostic signature of LGG and performed a integrative analysis of its molecular mechanisms and relationship with tumor immunity." 01/01/2021 - "Emerging studies on the predictive value of Small Nucleolar RNA Host Gene 7 (SNHG7) in human neoplasms give evidence of the association of SNHG7 with the human tumor. " 11/26/2020 - "Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar RNA host gene 15 (SNHG15) in malignancies, based on variable data from different studies. " 01/01/2020 - "Previous studies have elucidated the oncogenic role of small nucleolar RNA host gene 6 (SNHG6) in some types of human cancers, whereas it is unclear whether it functions as an oncogene in CC. "
2.	Carcinogenesis 01/01/2013 - "In this study, to investigate the physiological importance of mU50 snoRNA and its involvement in tumorigenesis, we eliminated mU50 snoRNA sequences from the mU50HG-b gene. " 01/01/2020 - "The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. " 11/01/2019 - "The expression and significance of small nucleolar RNA host gene 7 (SNHG7) in early-stage colon carcinogenesis remains unclear. " 01/01/2019 - "Small nucleolar RNA host gene 7 (SNHG7) is a novel identified oncogenic gene in tumorigenesis. " 01/01/2013 - "In the past years, evidence for the involvement of human U50 snoRNA in tumorigenesis has been accumulating. "
3.	Multiple Sclerosis 02/01/2016 - "SncRNA (microRNA &snoRNA) opposite expression pattern found in multiple sclerosis relapse and remission is sex dependent."
4.	PEHO syndrome 01/01/2022 - "We show that missense mutations modeling those found in PEHO syndrome patients cause a decrease in steady-state Hit1 protein levels, a significant reduction of box C/D snoRNA levels, and subsequent defects in rRNA processing and altered cellular translation. "
5.	Glioma (Gliomas) 01/01/2023 - "In the present study, we investigated the altered lncRNAs upon ER stress in glioma and found that small nucleolar RNA host gene 1 (SNHG1) was markedly increased in response to ER stress. " 01/01/2022 - "Conclusion: This study constructed a methylated snoRNA gene risk signature, which may provide a reference for glioma patients' prognosis assessment." 01/01/2019 - "This study will research the effects of Small Nucleolar RNA Host Gene 5 (SNHG5) gene on malignant cellular phenotypes in glioma and explore the possible mechanisms. " 01/01/2019 - "In the present study, we aimed to explore the molecular mechanism of small nucleolar RNA host gene 5 (SNHG5) in glioma progression. " 02/23/2018 - "In this study, we aimed to explore the functional involvement of small nucleolar RNA host gene 14 (SNHG14) and its potential regulatory mechanism in glioma progression. "

Related Drugs and Biologics

1.	MicroRNAs (MicroRNA)
2.	Proteins (Proteins, Gene)
3.	Small Untranslated RNA
4.	Sunitinib (Sutent)
5.	Bevacizumab (Avastin)
6.	atezolizumab
7.	Long Noncoding RNA
8.	Small Nucleolar RNA (snoRNA)
9.	RNA (Ribonucleic Acid)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Castration
4.	Injections
5.	Immunotherapy