Mononeuropathies (Mononeuritis Multiplex)

Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ISCHEMIA; traumatic injury; compression; CONNECTIVE TISSUE DISEASES; CUMULATIVE TRAUMA DISORDERS; and other conditions.

Also Known As:

Networked: 438 relevant articles (16 outcomes, 51 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperalgesia
2.	Vasculitis (Vasculitides)
3.	Neurologic Manifestations (Neurological Manifestations)
4.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
5.	Infection

Experts

1.	Lundeberg, T: 5 articles (11/2000 - 01/2000)
2.	Dyck, P James B: 4 articles (02/2016 - 05/2010)
3.	Dyck, Peter J: 4 articles (02/2016 - 05/2010)
4.	Guillevin, Loïc: 4 articles (02/2014 - 12/2007)
5.	Atweh, S F: 4 articles (01/2006 - 01/2002)
6.	Saadé, N E: 4 articles (01/2006 - 01/2002)
7.	Jabbur, S J: 4 articles (01/2006 - 01/2002)
8.	Thaisetthawatkul, Pariwat: 3 articles (02/2016 - 06/2011)
9.	Yu, Long-Chuan: 3 articles (07/2015 - 05/2007)
10.	Saadé, Nayef E: 3 articles (09/2012 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mononeuropathies:

1.	N-Methylaspartate (NMDA)IBA 06/10/2005 - "Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy." 12/11/1992 - "Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy." 03/05/1993 - "Dextrorphan (DEX), a non-competitive NMDA receptor antagonist, was given intraperitoneally and intrathecally (i.t.) to rats with an experimental painful peripheral mononeuropathy. " 02/24/1995 - "This study tested the prophylactic and therapeutic efficacy of memantine (1-amino-3,5-dimethyl-amandate), a clinically tested N-methyl-D-aspartate (NMDA) antagonist on thermal hyperalgesia in a rat model of painful mononeuropathy. " 02/01/1998 - "In this study, we investigated the suppressive effects of a clinically available NMDA antagonist, ketamine, and the mechanisms of its effects on neuropathic pain in rats with peripheral mononeuropathy. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2003 - "One group had a multiple mononeuropathy resembling reversal reactions with insufficient response to corticosteroids. " 01/01/2014 - "The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. " 10/01/2010 - "Small, uncontrolled, treatment trials with numerous immunomodulatory agents have reported variable benefit in PSS-associated neuropathy, particularly corticosteroids for mononeuritis multiplex and intravenous immunoglobulin for small fiber or sensory ataxic neuropathy. " 12/01/2003 - "Corticosteroids, cyclophosphamide, and anticoagulant therapy altered the hypereosinophilia and mononeuritis multiplex, but no visual recovery occurred during the following 2 years. " 06/01/2001 - "After systemic administration of corticosteroids, the symptoms other than mononeuritis improved markedly, and his MPO-ANCA and rheumatoid factor became negative. "
3.	Immunoglobulins (Immunoglobulin)IBA 02/01/2014 - "We describe a 54-year-old man with mononeuritis multiplex and reactive lymphoid hyperplasia with increased immunoglobulin G4 (IgG4)-positive cells. " 02/01/2014 - "Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells." 01/01/2011 - "Although intravenous high-dose immunoglobulin administration was transiently effective for mononeuritis multiplex, the recurrent high fever and severe abdominal pain remained refractory. " 10/01/2010 - "Small, uncontrolled, treatment trials with numerous immunomodulatory agents have reported variable benefit in PSS-associated neuropathy, particularly corticosteroids for mononeuritis multiplex and intravenous immunoglobulin for small fiber or sensory ataxic neuropathy. " 01/01/2014 - "We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and Treg cell frequency, during EGPA. "
4.	suralIBA 03/01/2014 - "Routine sural conduction study was positive in 34 of 36 patients, whereas a distal recording method was used to verify the diagnosis of sural mononeuropathy in 2 patients. " 03/01/2014 - "Sural mononeuropathy has distinct etiologic, clinical, and electrophysiological features. " 03/01/2014 - "Isolated sural mononeuropathy is rare and frequently constitutes a diagnostic challenge. " 03/01/2014 - "Sural mononeuropathy: a report of 36 cases." 02/01/2008 - "To enhance the accuracy for determining the precise localization, the findings of the compound nerve action potentials (CNAPs) of the common peroneal nerve (CPN) were investigated in patients with common peroneal mononeuropathy (CPM) in the knee, and the sural sensory nerve action potentials (SNAPs) were also analyzed. "
5.	amiridine (ipidacrine)IBA 01/01/2015 - "[A clinical-electroneuromyographic study of the efficacy of ipidacrine in patients with mononeuropathies]." 01/01/2015 - "To evaluate the efficacy and tolerability of axamon (ipidacrine) therapy in patients with focal neuropathies--mononeuropathies. " 01/01/2012 - "[The use of ipidacrinum (neuromidin) in mononeuropathies]." 01/01/1998 - "Rheumatic patients presented affections of the peripheral and central venous systems, vegetative dysfunction, disturbed higher nervous activity manifesting as polyneuropathy, mononeuropathy, pyramid syndrome, dystonia, hypothalamic syndrome, reduced adaptive ability, low tonicity of the sympathetic nervous system, terminal branches of the motor axons, etc. Therapy of nervous disorders in rheumatic patients comprises treatment of cerebral circulation (vascular, nootropic drugs, cerebrolysin), asthenic, neurotic and vegetative disorders (sedative and vegetotropic drugs, etimisol, adaptogens), abnormalities of peripheral nervous system (amiridin, anticholinesterase preparations, vitamins B and others). "
6.	Memantine (Namenda)FDA Link 02/24/1995 - "These results provide evidence that memantine produces long-term prophylactic and short-term therapeutic effects on thermal hyperalgesia in a model of painful mononeuropathy." 02/24/1995 - "This study tested the prophylactic and therapeutic efficacy of memantine (1-amino-3,5-dimethyl-amandate), a clinically tested N-methyl-D-aspartate (NMDA) antagonist on thermal hyperalgesia in a rat model of painful mononeuropathy. " 02/24/1995 - "The clinically tested N-methyl-D-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy." 03/01/2001 - "Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy."
7.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 06/01/1994 - "We describe three patients who presented with mononeuritis multiplex and positive tests for ANCA. " 05/01/2014 - "At the time of diagnosis ANCA-positive patients had a higher incidence of renal involvement (53% vs. 7.7%; p<0.001), skin involvement (93.3% vs. 57.1%; p=0.03), and peripheral neuropathy in the form of mononeuritis multiplex (60% vs. 25.7%; p=0.021). " 01/01/2011 - "He progressively developed ANCA positive multiple mononeuritis and crescentic glomerulonephritis. " 08/01/2007 - "We report the case of a man presenting with clinical features of a mononeuritis multiplex, a perinuclear-ANCA (p-ANCA), and a renal biopsy suggestive of Wegener granulomatosis (WG). " 01/01/2007 - "Laboratory tests often indicate features of systemic inflammation, such as an elevated sedimentation rate or positive anti-neutrophil cytoplasmic antibody, and electrodiagnostic evaluation shows multiple mononeuropathies or a confluent, asymmetric axonal neuropathy. "
8.	Rheumatoid FactorIBA 06/01/2002 - "We diagnosed as severe RA with extraarticular manifestations based on interstitial pneumonia, mononeuritis multiplex, subcutaneous nodules, and high titer of rheumatoid factor. " 04/01/1983 - "A 64-year-old Black woman presented with high titer serum rheumatoid factor (RF), pelvic girdle weakness, sensory mononeuropathy, pulmonary fibrosis, and muscle histologic evidence of small artery necrotizing vasculitis. " 02/01/1997 - "In her further clinical course, symptoms such as episcleritis, mononeuritis multiplex, skin ulcers on bilateral lower legs and circulating disturbance on left lower leg with high titer of rheumatoid factor were appeared in six months, suggesting malignant rheumatoid arthritis (MRA). " 05/01/2006 - "Electroneuromyographic examination found one case of polyneuropathy and four cases of multiplex mononeuropathies; the complement level was normal in all patients and the rheumatoid factor positive in two cases. " 10/01/1985 - "This report describes a 71-year-old man with biopsy-proved giant cell arteritis, mononeuritis (foot drop) multiplex, and high-titer complement-activating rheumatoid factor without rheumatoid arthritis. "
9.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2014 - "Mononeuritis multiple subsequently occurred, and steroid pulse therapy with cyclophosphamide was administered. " 05/01/2004 - "In July 2002, mononeuritis multiplex was diagnosed after the patient presented with paresthesiae and was treated with pulse cyclophosphamide therapy. " 12/01/2002 - "The symptoms were improved shortly by cyclophosphamide pulse therapy with plasmapheresis but symptoms were aggravated and symmetric mononeuropathy of the ulnar nerve developed. " 09/01/2004 - "Treatment by cyclophosphamide allowed a partial recovery or stabilization in patients with myelopathy (92%) or multiple mononeuropathy (100%). " 02/01/2004 - "Mononeuritis in Churg-Strauss syndrome in Asians responding to intravenous cyclophosphamide."
10.	Intravenous Immunoglobulins (IVIG)FDA Link 01/01/2015 - "In the rare occasion of peripheral nerve mononeuropathy during pregnancy, in which therapeutic opportunities are limited, IVIG therapy may be an option when the etiology cannot clearly be determined after thorough medical investigation." 08/01/1997 - "HIV related vasculitic mononeuropathy multiplex: a role for IVIg?" 12/01/2012 - "The effectiveness of IVIg has been proven in Guillain-Barré syndrome (level A), chronic inflammatory demyelinating polyradiculoneuropathy (level A), multifocal mononeuropathy (level A), acute exacerbations of myasthenia gravis and short-term treatment of severe myasthenia gravis (level A). " 09/01/2008 - "The efficacy of IVIG has been proven in Guillain-Barré syndrome (level A), chronic inflammatory demyelinating polyradiculoneuropathy (level A), multifocal mononeuropathy (level A), acute exacerbations of myasthenia gravis (MG) and short-term treatment of severe MG (level A recommendation), and some paraneoplastic neuropathies (level B). " 01/01/2014 - "We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and Treg cell frequency, during EGPA. "

Therapies and Procedures

1.	Plasmapheresis 12/01/2002 - "The symptoms were improved shortly by cyclophosphamide pulse therapy with plasmapheresis but symptoms were aggravated and symmetric mononeuropathy of the ulnar nerve developed. " 01/01/1988 - "Acute or chronic inflammatory demyelinating polyneuropathy (38%) and mononeuropathy multiplex (29%) are most frequently seen, and usually there is a good prognosis, with the neuropathy resolving spontaneously or with steroids or plasmapheresis. " 11/01/1994 - "There are also efficacy of amytriptylinein controlling HIV headache, corticosteroid in mononeuritis multiple and inflammatory myositis, hydrocortisone in autonomic neuropathy and plasmapheresis in distal sensory neuropathy respectively. " 09/01/2015 - "For HCV-CryoVas with severe vasculitis (ie, worsening of renal function, mononeuritis multiplex, extensive skin disease, intestinal ischemia…) control of disease with rituximab, with or without plasmapheresis, is required before initiation of antiviral therapy. " 03/24/1990 - "Immunosuppressants and plasmapheresis in the treatment of the demyelinating IgM-kappa neuropathies, of paraproteinemia with the motor neuron disease-like syndrome, and of mononeuropathy or multifocal neuropathy with cryoglobulinemia, are of doubtful value.(ABSTRACT TRUNCATED AT 250 WORDS)"
2.	Transplants (Transplant) 07/01/1998 - "During follow-up periods of 1 or more years, seven of nine patients with localized hypertrophic mononeuropathy treated with graft repairs were either unchanged or improved. " 03/01/2007 - "Alternatively, other complications such as myositis, myasthenia gravis, and mononeuropathy multiplex may result from a dysimmune systemic disorder such as post-transplant lymphoproliferative disorder, graft-versus-host disease or hepatitis C virus or hepatitis B virus chronic infection. "
3.	Induced Hyperthermia (Thermotherapy) 01/01/2009 - "One month later, after induction therapy, fever, livedo reticularis and peripheral mononeuropathy developed with hypocomplementemia and the patient was treated successfully with glucocorticoid pulse therapy."
4.	Analgesia 02/01/2014 - "The efficacy of EFX analgesia and the contribution of 3αNS were evaluated in a rat model of mononeuropathy. " 02/01/2014 - "Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy."
5.	Ligation 07/10/2015 - "The present study was performed in rats with mononeuropathy induced by left common sciatic nerve ligation. " 11/07/2014 - "The present study was conducted on rats with mononeuropathy induced by left common sciatic nerve ligation. " 01/29/2000 - "The present study was performed in rats with experimentally induced mononeuropathy after common sciatic nerve ligation. " 01/01/2000 - "The present study was performed in rats with experimentally induced mononeuropathy after left common sciatic nerve ligation. " 04/01/1999 - "Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: behavioral, electrophysiological and histopathologic studies."