Interleukin-7 Receptors (Interleukin 7 Receptor)

Cell surface receptors that are specific for INTERLEUKIN-7. They are present on T-LYMPHOCYTES and B-LYMPHOCYTE precursors. The receptors are heterodimeric proteins consisting of the INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR COMMON BETA SUBUNIT.

Also Known As:

Networked: 110 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ming, Jian: 3 articles (08/2012 - 03/2009)
2.	Okamoto, Ryuichi: 3 articles (02/2011 - 08/2003)
3.	Watanabe, Mamoru: 3 articles (02/2011 - 08/2003)
4.	Kanai, Takanori: 3 articles (02/2011 - 08/2003)
5.	Nakamura, Tetsuya: 3 articles (02/2011 - 08/2003)
6.	Cooper, David A: 3 articles (04/2010 - 02/2006)
7.	Sasson, Sarah C: 3 articles (04/2010 - 02/2006)
8.	Kelleher, Anthony D: 3 articles (04/2010 - 02/2006)
9.	Zaunders, John J: 3 articles (04/2010 - 02/2006)
10.	Leonard, Warren J: 3 articles (04/2008 - 01/2005)

Related Diseases

1.	Necrosis 02/01/2000 - "Studies in cytokine- and cytokine-receptor-gene-knockout (-/-) mice demonstrated that mice that are IL-2 -/- and IL-7 receptor -/- produce the same CTLp response to M-FP as do control mice, whereas responses in the IL-6 -/-, IL-10 -/- and IFNgamma -/- mice were marginally improved and responses to M-FP in IL-4 -/- and tumour necrosis factor receptor 2 -/- mice were weaker. "
2.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 11/01/2009 - "Delayed onset of (severe) combined immunodeficiency (S)CID (T-B+NK+): complete IL-7 receptor deficiency in a 22 months old girl." 11/01/2009 - "Thus even in patients with moderate clinical symptoms and delayed onset a (T-B+NK+) (Severe) Combined Immunodeficiency ((S)CID)) due to missing IL-7 receptor signalling must be considered." 11/01/2009 - "Usually IL-7 receptor deficiency presents as (T-B+NK+) (Severe) Combined Immunodeficiency (SCID) within the first six months of life. " 01/01/2005 - "The essential non-redundant role of this cytokine for T cell development in vivo is indicated by the phenotype of murine knockout models as well as by humans with a T-B+NK+ form of severe combined immunodeficiency (SCID) resulting from mutations in IL-7 receptor alpha chain. " 08/01/2000 - "Recently, two SCID (severe combined immunodeficiency disease) patients with greatly diminished T cells but normal or increased numbers of B and NK cells (T(-)B(+)NK(+) SCID) were found to have mutations in the gene for the IL-7 receptor. "
3.	Sjogren's Syndrome (Sjogren Syndrome) 12/01/2012 - "Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression."
4.	Obesity 10/01/2015 - "IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice." 10/01/2015 - "Although the IL-7 receptor (IL-7R) is mostly known as a key regulator of T lymphocyte development and homeostasis, its role in obesity and metabolic diseases is unknown. "
5.	Insulin Resistance 10/01/2015 - "IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice."

Related Drugs and Biologics

1.	Cytokine Receptors (Cytokine Receptor)
2.	Interleukin-2 (IL2)
3.	Interleukin-4 (Interleukin 4)
4.	Interleukin-10 (Interleukin 10)
5.	Interleukin-6 (Interleukin 6)
6.	leflunomide (Arava)
7.	Interleukin-7 (Interleukin 7)
8.	Janus Kinases
9.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
10.	Interferons

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Ligation