Acidic Glycosphingolipids

A subclass of GLYCOSPHINGOLIPIDS containing large polar heads made up of several sugar units. One or more of their terminal sugar units are bound to a negatively charged molecule at pH 7. Members of this class include: GANGLIOSIDES, uronoglycosphingolipids, SULFOGLYCOSPHINGOLIPIDS, phosphoglycosphingolipids, and phosphonoglycosphingolipids.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Noura, Shingo: 2 articles (06/2009 - 05/2007)
2.	Ohue, Masayuki: 2 articles (06/2009 - 05/2007)
3.	Miyamoto, Yasuhide: 2 articles (06/2009 - 05/2007)
4.	Korekane, Hiroaki: 2 articles (06/2009 - 05/2007)
5.	Misonou, Yoshiko: 1 article (06/2009)
6.	Seki, Yosuke: 1 article (06/2009)
7.	Shida, Kyoko: 1 article (06/2009)
8.	Resić, Jasminka: 1 article (01/2008)
9.	Bozić, Josko: 1 article (01/2008)
10.	Markotić, Anita: 1 article (01/2008)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1996 - "This cellular membrane over-expression and shedding of acidic glycosphingolipids into the interstitial spaces and blood of cancer patients may play a central role in increased tumour cell growth, lack of immune cell recognition and neovascularization and could represent a molecular target for cancer therapy." 09/01/1999 - "Two acidic glycosphingolipids (gangliosides) derived from mouse macrophage membranes and separated by thin-layer chromatography have a strong cytostatic effect on human and mouse tumor cells. " 01/01/1988 - "Neutral and acidic glycosphingolipids of Friend cells were characterized in 1) undifferentiated Friend cells (745A), 2) differentiated Friend cells induced with dimethyl-sulfoxide, and 3) solid tumors grown in mice after subcutaneous implantation of Friend cells. " 02/15/1992 - "I3SO3-GalCer, which was contained in the original tissues of uterine endometrial adenocarcinomas, disappeared completely from the cultured cells at the 70th doubling time, whereas II3SO3-LacCer and ganglio series sulfoglycosphingolipids, which were originally contained in a trace amount or not present at all in the cancer tissues, became the major components in the total acidic glycosphingolipids in the cultured cells. " 01/15/1992 - "In particular, more than 90% of the acidic glycosphingolipids in the mucinous cystadenocarcinoma is comprised of sulfolipids, which are hardly detected in normal ovary and are contained in concentrations of less than 40% in the other type of ovarian tumors. "
2.	Astrocytoma (Pilocytic Astrocytoma) 01/01/1992 - "For the present paper, we set out to analyse the composition of membrane lipids (cholesterol, phospholipids, neutral and acidic glycosphingolipids, sulphatides) in human cerebral astrocytomas, which is a group of tumors that offer a valid model for the study of the various grades of cellular transformations in vivo. "
3.	Adenocarcinoma 05/01/2007 - "The structures of acidic glycosphingolipids in colon adenocarcinoma have been analyzed extensively using a number of conventional methods, such as thin-layer chromatography and methylation analysis, and a variety of acidic glycosphingolipids present in the tissues have been reported. " 05/01/2007 - "In this technique, the carbohydrate moieties of acidic glycosphingolipids from approximately 20mg of colon adenocarcinoma were released by endoglycoceramidase II and were labeled by pyridylamination. " 02/15/1992 - "I3SO3-GalCer, which was contained in the original tissues of uterine endometrial adenocarcinomas, disappeared completely from the cultured cells at the 70th doubling time, whereas II3SO3-LacCer and ganglio series sulfoglycosphingolipids, which were originally contained in a trace amount or not present at all in the cancer tissues, became the major components in the total acidic glycosphingolipids in the cultured cells. "
4.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/1994 - "Re-assessment of acidic glycosphingolipids in small-cell-lung-cancer tissues and cell lines."
5.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 04/01/1991 - "Sera from 23 patients with acute Guillain Barré syndrome (GBS), 15 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and from 40 age-matched blood donors were analysed for antibodies to acidic glycosphingolipids from human brain and peripheral nerve. "

Related Drugs and Biologics

1.	Phospholipids
2.	Membrane Lipids
3.	Cholesterol
4.	Sulfoglycosphingolipids (Sulfatides)
5.	Gangliosides
6.	Neutral Glycosphingolipids
7.	Phosphatidic Acids (Phosphatidic Acid)
8.	Dimethyl Sulfoxide (DMSO)
9.	Antigens
10.	Antibodies