Acidic Glycosphingolipids

A subclass of GLYCOSPHINGOLIPIDS containing large polar heads made up of several sugar units. One or more of their terminal sugar units are bound to a negatively charged molecule at pH 7. Members of this class include: GANGLIOSIDES, uronoglycosphingolipids, SULFOGLYCOSPHINGOLIPIDS, phosphoglycosphingolipids, and phosphonoglycosphingolipids.

Also Known As:

Networked: 20 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Korekane, Hiroaki: 2 articles (06/2009 - 05/2007)
2.	Miyamoto, Yasuhide: 2 articles (06/2009 - 05/2007)
3.	Noura, Shingo: 2 articles (06/2009 - 05/2007)
4.	Ohue, Masayuki: 2 articles (06/2009 - 05/2007)
5.	Chan, Wai-Him: 1 article (12/2019)
6.	Chen, Li: 1 article (12/2019)
7.	Huang, Hao: 1 article (12/2019)
8.	Jiang, Zhi-Hong: 1 article (12/2019)
9.	Luo, Pei: 1 article (12/2019)
10.	Meng, Xiong-Yu: 1 article (12/2019)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1996 - "This cellular membrane over-expression and shedding of acidic glycosphingolipids into the interstitial spaces and blood of cancer patients may play a central role in increased tumour cell growth, lack of immune cell recognition and neovascularization and could represent a molecular target for cancer therapy." 09/01/2023 - "Gangliosides (acidic glycosphingolipids) have crucial regulatory roles in normal physiological processes, as well as in pathological conditions, including tumor onset and progression. " 01/01/1988 - "Neutral and acidic glycosphingolipids of Friend cells were characterized in 1) undifferentiated Friend cells (745A), 2) differentiated Friend cells induced with dimethyl-sulfoxide, and 3) solid tumors grown in mice after subcutaneous implantation of Friend cells. " 02/15/1992 - "I3SO3-GalCer, which was contained in the original tissues of uterine endometrial adenocarcinomas, disappeared completely from the cultured cells at the 70th doubling time, whereas II3SO3-LacCer and ganglio series sulfoglycosphingolipids, which were originally contained in a trace amount or not present at all in the cancer tissues, became the major components in the total acidic glycosphingolipids in the cultured cells. " 01/15/1992 - "In particular, more than 90% of the acidic glycosphingolipids in the mucinous cystadenocarcinoma is comprised of sulfolipids, which are hardly detected in normal ovary and are contained in concentrations of less than 40% in the other type of ovarian tumors. "
2.	Astrocytoma (Pilocytic Astrocytoma) 01/01/1992 - "For the present paper, we set out to analyse the composition of membrane lipids (cholesterol, phospholipids, neutral and acidic glycosphingolipids, sulphatides) in human cerebral astrocytomas, which is a group of tumors that offer a valid model for the study of the various grades of cellular transformations in vivo. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 05/01/2023 - "Gangliosides (GAs) and sulfatides (STs) are acidic glycosphingolipids that are particularly abundant in the nervous system and are closely related to aging and neurodegenerative disorders. " 12/01/2019 - "Gangliosides (GAs) and sulfatides (STs) are major acidic glycosphingolipids (GSLs) that are particularly abundant in the central nervous system and associated with substantial neurodegenerative diseases. "
4.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/1994 - "Re-assessment of acidic glycosphingolipids in small-cell-lung-cancer tissues and cell lines."
5.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 04/01/1991 - "Sera from 23 patients with acute Guillain Barré syndrome (GBS), 15 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and from 40 age-matched blood donors were analysed for antibodies to acidic glycosphingolipids from human brain and peripheral nerve. "

Related Drugs and Biologics

1.	Phospholipids (Phosphatides)
2.	Membrane Lipids
3.	Cholesterol
4.	Sulfoglycosphingolipids (Sulfatides)
5.	Gangliosides
6.	Cytostatic Agents
7.	Neutral Glycosphingolipids
8.	Phosphatidic Acids (Phosphatidic Acid)
9.	Lipids
10.	Hemostatics (Antihemorrhagics)

Related Therapies and Procedures

1.	Therapeutics