Knee Osteoarthritis

Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

Also Known As:

Networked: 1893 relevant articles (245 outcomes, 554 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Low Back Pain (Lumbago)
3.	Inflammation
4.	Osteoarthritis
5.	Rheumatoid Arthritis

Experts

1.	Honsawek, Sittisak: 14 articles (01/2015 - 06/2009)
2.	Chevalier, Xavier: 14 articles (01/2015 - 07/2005)
3.	Tanavalee, Aree: 13 articles (01/2015 - 06/2009)
4.	Felson, David T: 12 articles (08/2015 - 07/2002)
5.	Pelletier, Jean-Pierre: 11 articles (01/2016 - 05/2006)
6.	Raynauld, Jean-Pierre: 11 articles (02/2015 - 02/2005)
7.	Garnero, Patrick: 11 articles (12/2012 - 10/2002)
8.	Kraus, V B: 10 articles (12/2015 - 10/2001)
9.	Kraus, Virginia B: 10 articles (11/2015 - 06/2004)
10.	Reginster, Jean-Yves: 10 articles (08/2014 - 07/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Knee Osteoarthritis:

1.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2011 - "Euflexxa(®) (high molecular weight hyaluronate), a bioengineered high molecular weight hyaluronan, has been shown to be a safe and effective treatment for patients with knee osteoarthritis. " 05/01/2003 - "The results showed that both intra-articular hyaluronic acid and 6-MPA treatments provide clinically significant improvement and demonstrated that Na HA has a long-term beneficial effect in patients with knee osteoarthritis." 01/01/2015 - "Thus it can be proved that content of IL-1β in knee joint synovial fluid KOA patients is higher than healthy people; sodium hyaluronate can reduce the content of IL-1β in synovial joints and can be effective in the treatment of knee osteoarthritis. " 01/01/2013 - "Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis." 04/01/2010 - "Is hyaluronate sodium effective in the management of knee osteoarthritis? "
2.	Diclofenac (SR 38)FDA LinkGeneric 03/01/2012 - "Determine the efficacy of Ayurved Siriraj Wattana Recipe for knee osteoarthritis in a randomized, open-label, diclofenac-controlled trial for 12 weeks. " 01/01/2011 - "Safety and efficacy of topical diclofenac sodium gel for knee osteoarthritis in elderly and younger patients: pooled data from three randomized, double-blind, parallel-group, placebo-controlled, multicentre trials." 06/01/2010 - "Safety and efficacy of topical diclofenac sodium 1% gel in knee osteoarthritis: a randomized controlled trial." 01/01/2015 - "[Controlled clinical study on compound Decumbent Corydalis Rhizome and diclofenac in treatment of knee osteoarthritis]." 01/01/2015 - "A phase 2, double-blind, randomized, and controlled trial study with a purpose to determine the clinical efficacy and safety of SHT in comparison with diclofenac for the treatment of knee osteoarthritis. "
3.	hylanIBA 01/01/2003 - "Hylan G-F 20 was safe and effective in knee osteoarthritis and had a relatively low cost-utility ratio." 04/01/2008 - "The purpose of this study was to evaluate the efficacy of hylan G-F 20 when used to treat an active and athletic patient population with knee osteoarthritis who had undergone knee arthroscopy for mechanical symptoms. " 01/01/2014 - "Long-Term (1-Year) Safety and Efficacy of a Single 6-mL Injection of Hylan G-F 20 in Indian Patients with Symptomatic Knee Osteoarthritis." 10/01/2009 - "Functional improvement with hylan G-F 20 in patients with knee osteoarthritis." 02/01/2005 - "To compare the effectiveness and safety of repeat treatment with hylan G-F 20 based on data from a randomized, controlled trial [Raynauld JP, Torrance GW, Band PA, Goldsmith CH, Tugwell P, Walker V, et al. A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with knee osteoarthritis (Part 1 of 2): clinical results. "
4.	Glucosamine (Dona)IBA 01/01/2012 - "A randomized comparative study of safety and efficacy of immediate release glucosamine HCL and glucosamine HCL sustained release formulation in the treatment of knee osteoarthritis: A proof of concept study." 01/01/2012 - "To compare the safety and efficacy of glucosamine HCl- sustained release (GLU-SR) with that of Glucosamine HCl- immediate release (GLU-IR) in patients with knee osteoarthritis (OA). " 02/01/2013 - "Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles." 08/15/2005 - "Efficacy of glucosamine sulfate in knee osteoarthritis: comment on the article by Cibere et al." 10/15/2004 - "To assess the efficacy of glucosamine sulfate in knee osteoarthritis (OA). "
5.	Acetaminophen (Paracetamol)FDA LinkGeneric 10/01/2012 - "The objective of this study was to assess the satisfaction of patients diagnosed with hip and/or knee osteoarthritis who had been previously treated with paracetamol and switched to NSAID treatment due to a lack of effectiveness by paracetamol. " 11/01/2014 - "Determine efficacy and safety of acetaminophen extended release (ER) 1300 mg given three times daily compared to placebo for relieving signs and symptoms of hip or knee osteoarthritis. " 03/01/2014 - "[Platelet rich plasma versus oral paracetamol for the treatment of early knee osteoarthritis. " 09/01/2009 - "Patient preference for sustained-release versus standard paracetamol (acetaminophen): a multicentre, randomized, open-label, two-way crossover study in subjects with knee osteoarthritis." 10/01/2001 - "Use of acetaminophen in alcoholic patients: comment on the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarthritis."
6.	Chondroitin Sulfates (Chondroitin Sulfate)IBA 03/01/2005 - "To determine whether chondroitin sulfate (CS) is effective in inhibiting cartilage loss in knee osteoarthritis (OA). " 06/01/2010 - "To update a published meta-analysis of double-blind placebo-controlled randomized clinical trials (RCTs) to assess the efficacy of chondroitin sulfate as a structure-modifying drug for knee osteoarthritis (OA). " 01/01/2012 - "Symptom-modifying effect of chondroitin sulfate in knee osteoarthritis: a meta-analysis of randomized placebo-controlled trials performed with structum(®)." 06/01/2010 - "Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration." 05/01/1998 - "This multicenter randomized, double-blind, controlled study was performed to compare the efficacy and tolerability of chondroitin sulfate (CS, Condrosulf, IBSA, Lugano, CH) 1200 mg/day oral gel vs CS 3 x 400 mg/day capsules vs placebo, in patients with mono or bilateral knee osteoarthritis (Kellgren and Lawrence radiographic score grade I to III). "
7.	salicylhydroxamic acid (SHAM)IBA 09/01/2010 - "We conducted a 3-month randomized clinical trial in patients with knee osteoarthritis to compare the efficacy of TCA with sham acupuncture and to examine the effects of acupuncturists' communication styles. " 05/01/2014 - "The aim of this study was to compare whether the effectiveness of continuous ultrasound (US) was superior against pulsed US and against sham US in knee osteoarthritis. " 12/26/2013 - "In this trial involving patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, the outcomes after arthroscopic partial meniscectomy were no better than those after a sham surgical procedure. " 12/26/2013 - "We conducted a multicenter, randomized, double-blind, sham-controlled trial in 146 patients 35 to 65 years of age who had knee symptoms consistent with a degenerative medial meniscus tear and no knee osteoarthritis. " 01/01/2013 - "This article describes the rationale and methodology of a randomized sham-controlled trial to assess the benefit of arthroscopic partial meniscectomy of a medial meniscus tear in patients with mild or no knee osteoarthritis. "
8.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 02/01/2010 - "In conclusion, the local application of a plaster with NSAIDs leads to the same level of improvement in knee osteoarthritis as oral NSAIDs." 03/01/2011 - "The purpose of this study was to determine muscle and tendon protein fractional synthesis rates (FSR) at rest and after a one-legged kicking exercise in patients with knee osteoarthritis (OA) receiving either placebo or nonsteroidal anti-inflammatory drugs (NSAIDs). " 01/01/2011 - "To compare the prescription modalities of general practitioners (GPs) and rheumatologists (RHs) for symptomatic knee osteoarthritis (OA) and to determine correlates with prescription of low-dose NSAIDs. " 09/01/2009 - "The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on knee osteoarthritis progression are unclear. " 12/01/2008 - "In medial knee osteoarthritis, foot pronation orthotics--when there are no contraindications--can be proposed for their symptomatic impact, especially in the decrease of NSAIDs consumption (Grade B). "
9.	celecoxib (Celebrex)FDA Link 02/26/2004 - "SAMe has a slower onset of action but is as effective as celecoxib in the management of symptoms of knee osteoarthritis. " 12/01/2010 - "The aim of the study was to evaluate by quantitative magnetic resonance imaging the effect of celecoxib 200 mg daily on cartilage volume loss over 12 months in knee osteoarthritis. " 04/01/2009 - "The objective was to substantiate these beneficial effects in an in vivo (clinical) study with celecoxib treatment of patients with severe knee osteoarthritis (OA) and subsequent evaluation of cartilage tissue ex vivo. " 04/01/2014 - "Fifty-three percent of knee osteoarthritis patients requesting celebrex would receive it, compared with 24% of patients making no request (P = 0.001). " 10/07/2013 - "This prospective, randomized, double-blind, multicenter study compared the efficacy and safety of Celecoxib and GCSB-5, a new product from extracts of six herbs, for the treatment of knee osteoarthritis. "
10.	3- (3- dimethylamino- 1- ethyl- 2- methylpropyl)phenolFDA Link 01/01/2015 - "Subgroup analysis showed a higher improvement with tapentadol among patients with knee osteoarthritis and among pooled results from studies of higher quality and shorter follow-up period, although there were no statistical significant differences in the effect size between these subgroups. " 09/01/2015 - "Tolerability and efficacy of tapentadol extended release in elderly patients ≥ 75 years of age with chronic osteoarthritis knee or low back pain." 09/01/2015 - "Data were pooled from three similarly designed, randomized, doubleblind, placebo- and active-controlled, phase 3 studies of tapentadol ER for moderate to severe, chronic osteoarthritis knee (NCT00421928, NCT00486811) or low back (NCT00449176) pain, and data for patients ≥ 75 years of age were evaluated. " 08/01/2014 - "We performed a post hoc analysis of data pooled from three randomized, placebo- and active-controlled, phase III studies of tapentadol ER for managing chronic osteoarthritis knee (NCT00421928, NCT00486811) or low back (NCT00449176) pain (15-week, double-blind treatment period). " 06/01/2014 - "Driving Ability in Patients with Severe Chronic Low Back or Osteoarthritis Knee Pain on Stable Treatment with Tapentadol Prolonged Release: A Multicenter, Open-label, Phase 3b Trial."

Therapies and Procedures

1.	Intra-Articular Injections 07/01/2005 - "The efficacy of combined therapy of intra-articular injection of SH and SHO for knee osteoarthritis was superior to that of intra-articular injection of SH only." 05/01/2014 - "The purpose of this study was to assess the safety and efficacy of intra-articular injection of autologous adipose tissue derived MSCs (AD-MSCs) for knee osteoarthritis. " 05/01/2015 - "In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated. " 05/01/2015 - "In a randomized, controlled, double-blind trial, 196 patients with symptomatic knee osteoarthritis (mean age ± SD, 59.4 ± 9.9 years, Kellgren-Lawrence grade 1-3) were given either 3 weekly intra-articular injections of HA or saline (placebo). " 09/01/2013 - "The goal of this study is to evaluate repairing effects of intra-articular injection of PG use in a rat model of knee osteoarthritis (OA). "
2.	Injections 06/01/2011 - "Corticosteroid joint injections are perceived as being an effective treatment for symptomatic knee osteoarthritis, with a very low risk of complications. " 08/01/2004 - "Steroid injections effective for knee osteoarthritis." 12/01/2004 - "To evaluate long term efficacy of three iterative courses of three weekly intra-articular (IA) injections of NRD101 in the treatment of symptomatic knee osteoarthritis (OA). " 01/01/2015 - "Prior studies describing the treatment of symptomatic knee osteoarthritis with injections of bone marrow concentrate have provided encouraging results. " 11/01/2011 - "A multicentre, randomised, patient and evaluator-blinded, controlled study in 306 patients fulfilling American College of Rheumatology criteria for knee osteoarthritis, radiological grades II-III (Kellgren-Lawrence) and joint space width ≥ 2 mm. Patients received four cycles of five intra-articular HA or placebo injections with a follow-up of 6 months after the first and second cycles, and 1 year after the third and fourth cycles. "
3.	Resistance Training 03/01/2015 - "[Conclusion] The results of this study suggest that combined application of progressive resistance training and Russian electrical stimulation can be effective in strengthening the quadriceps femoris muscle in elderly women with knee osteoarthritis. " 01/01/2009 - "This article provides the rationale and methodology, of the first randomised controlled trial to our knowledge designed to assess the efficacy of progressive resistance training on cartilage morphology in women with knee osteoarthritis.Development" 09/01/2015 - "Efficacy of Blood Flow-Restricted Low-Load Resistance Training For Quadriceps Strengthening in Men at Risk of Symptomatic Knee Osteoarthritis." 04/01/2015 - "Efficacy of blood flow-restricted, low-load resistance training in women with risk factors for symptomatic knee osteoarthritis." 01/15/2010 - "Middle-aged, sedentary persons with mild early knee osteoarthritis benefited from strength training, self-management, and the combination program. "
4.	Arthroplasty 10/01/2014 - "The authors concluded that total knee arthroplasty may be a safe and effective surgical intervention for adults with TAR syndrome and associated knee osteoarthritis. " 05/01/2010 - "This study indicates that for knee osteoarthritis patients treated with primary total knee arthroplasty, a 10-day multidisciplinary outpatient rehabilitation programme 2-4 months after surgery does not yield faster attainment of functional recovery or improvement in quality of life than can be achieved with conventional care." 03/01/2014 - "The objective indicators which reflect the past results of end-stage knee osteoarthritis (OA) patients who have already received total knee arthroplasty (TKA) could be helpful for physicians to discuss with patients who are considering TKA. " 12/01/2013 - "Total knee arthroplasty (TKA) is the gold standard treatment for end-stage knee osteoarthritis. " 10/01/2015 - "Fifty-three patients (71 knees) with primary varus knee osteoarthritis and who underwent total knee arthroplasty were selected for this study. "
5.	Transcutaneous Electric Nerve Stimulation (TENS) 08/01/2004 - "No significant difference was found among the four treatment protocols, but the addition of TENS to exercise training tended to produce the best overall improvement in physical outcomes in people with knee osteoarthritis." 10/01/2001 - "Two positive recommendations of clinical benefit were developed: (1) transcutaneous electrical nerve stimulation (TENS) and therapeutic exercises were beneficial for knee osteoarthritis, and (2) there was good agreement with these recommendations from practitioners (73% for TENS, 98% for exercises). " 01/01/2008 - "The present study tests whether a combined treatment of acupuncture and transcutaneous electrical nerve stimulation (TENS) is more effective than acupuncture or TENS alone for treating knee osteoarthritis (OA). " 10/01/2014 - "To study the effects of transcutaneous electrical nerve stimulation (TENS) on joint position sense (JPS) in knee osteoarthritis (OA) subjects. " 01/01/2008 - "[Does transcutaneous electrical nerve stimulation or therapeutic ultrasound increase the effectiveness of exercise for knee osteoarthritis: a randomized controlled study]."