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Methylmethacrylate (Metaplex)

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The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.

Also Known As:

Metaplex; Simplex P; Sintex; P, Simplex; Cranioplast; Kallocryl; Kallocryl A; Methacrylate Methyl Monomer; Zimmer Bone Cement; A, Kallocryl; Bone Cement, Zimmer; Cement, Zimmer Bone; Methyl Monomer, Methacrylate; Methyl Monomer, Methylmethacrylate; Monomer, Methacrylate Methyl; Monomer, Methylmethacrylate Methyl; Methylmethacrylate Methyl Monomer; 2-Propenoic acid, 2-methyl- methyl ester

Networked: 226 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Amaro, Cristina: 2 articles (02/2012 - 01/2012)
2.	Cardoso, Jorge: 2 articles (02/2012 - 01/2012)
3.	Maio, Paula: 2 articles (02/2012 - 01/2012)
4.	Carvalho, Rodrigo: 2 articles (02/2012 - 01/2012)
5.	Santos, Raquel: 2 articles (02/2012 - 01/2012)
6.	Lewis, G: 2 articles (08/2007 - 01/2000)
7.	Belkoff, S M: 2 articles (07/2001 - 05/2000)
8.	Mathis, J M: 2 articles (07/2001 - 05/2000)
9.	Furlanetto, Tania Weber: 1 article (06/2015)
10.	Rados, Dimitris Varvaki: 1 article (06/2015)

Related Diseases

1.	Fatigue 05/01/1990 - "Simplex P bone cement was prepared in three commercially available vacuum mixing systems, the Enhancement Mixer, the Mixevac II High Vacuum System, and the Mitab Vacuum System, to determine the improvement in fatigue strength associated with porosity reduction of the cement in all three systems. " 04/01/1989 - "Centrifugation significantly improved the fatigue properties of Simplex P and AKZ. " 06/01/2006 - "In mechanical fatigue, there were no significant differences in the log cycles to failure among the cements; however, Weibull analysis predicted Surgical Simplex P to have a higher characteristic life than the other cements. " 01/01/2001 - "The performance of three vacuum-mixing cement guns--a comparison of the fatigue properties of simplex P cement." 01/01/2000 - "Third, hand-mixed Osteopal outperforms vacuum-mixed Simplex P (especially at low alternating stress levels), indicating that MW(w) of a bone cement is more influential than mixing method on its fatigue performance."
2.	Spontaneous Fractures (Pathological Fracture) 09/01/1982 - "This study appears to clearly indicate that methylmethacrylate enhances the stability of the pathological fracture and contributes to achieving the goals of treatment in these severely compromised patients." 01/01/1976 - "Pathologic fractures of femoral shaft: study of internal fixation techniques incorporating methylmethacrylate." 01/01/1988 - "From this series, we conclude that any patient who has a pathologic fracture or impending fracture of the humerus and a predicted survival of six weeks or more is likely to benefit from rigid internal fixation with an appropriately selected device, adjunctive use of methylmethacrylate, and postoperative local irradiation therapy as needed." 09/01/1984 - "Internal fixation, supplemented with methylmethacrylate to fill bone defects, is the standard treatment for pathologic fractures. " 09/01/1982 - "Subtrochanteric pathological fractures should be internally fixed using a Zickel nail and methylmethacrylate. "
3.	Compression Fractures (Compression Fracture) 06/01/2008 - "Osteoporotic compression fractures can be effectively treated with methylmethacrylate vertebral augmentation. " 02/01/2003 - "Vertebral compression fractures what time destroys, methylmethacrylate may mend." 04/15/2000 - "This was a retrospective review of 47 consecutive patients (1995-1998) in whom percutaneous intraosseous methylmethacrylate cement injection (percutaneous vertebroplasty) was used to treat osteoporotic vertebral compression fractures and spinal column neoplasms. " 07/15/2001 - "To determine the strength and stiffness of osteoporotic vertebral bodies subjected to compression fractures and stabilized via bipedicular injections of the following: 1) Simplex P (Stryker-Howmedica-Osteonics, Rutherford, NJ), 2) Simplex P formulated consistent with the practice of vertebroplasty (F2), or 3) BoneSource (Stryker-Howmedica-Osteonics). " 05/01/2000 - "To determine the strength and stiffness of osteoporotic vertebral bodies subjected to compression fractures and subsequently stabilized via bipedicular injection of one of two bone cements: one is a commercially available polymethylmethacrylate (Simplex P) and one is a proprietary glass-ceramic-reinforced BisGMA/BisEMA/TEGDMA matrix composite that is being developed for use in vertebroplasty (Orthocomp). "
4.	Hypotension (Low Blood Pressure) 07/01/1995 - "The purpose of this in vitro study was to determine if methylmethacrylate monomer could produce hypotension by acting directly on vascular smooth muscle. " 09/01/1998 - "The use of monomeric methylmethacrylate (MMA) bone cement causes hypotension by several mechanisms. " 05/01/1985 - "Surgical fixation with methylmethacrylate did not produce profound or prolonged hypotension despite sudden massive blood loss prior to its use. " 10/01/1978 - "We did not encounter any hypotension during surgery or as a result of the methylmethacrylate. " 01/27/1973 - "Hypotension and methylmethacrylate cement."
5.	Congenital Abnormalities (Deformity) 09/01/2006 - "Chest wall resection followed immediately by reconstruction utilizing synthetic mesh with a filler of methylmethacrylate with or without local or pedicled muscle flaps can be performed as a safe, effective one-stage surgical procedure for major chest wall defects which prevents paradoxical movement of chest wall and overcomes deformity." 08/01/1980 - "Preformed methylmethacrylate prostheses have in such cases been implanted in patients with significant skull deformities with only minimal morbidity. " 08/01/1980 - "Methylmethacrylate onlay implants in the treatment of forehead deformities secondary to craniosynostosis." 12/01/2011 - "Prefabricated methylmethacrylate implants, with the aid of modeling clay, computer imaging, and modern rapid-prototyping technologies, fits the depression deformity well and balances the skeletal contour. " 10/01/1993 - "Eighteen of the 124 patients enrolled in the gentamicin methylmethacrylate bead (GMB; Septopal) study had infected deformities that were treated with the Ilizarov external fixator. "

Related Drugs and Biologics

1.	Polymethyl Methacrylate (Sol)
2.	Gentamicins (Gentamicin)
3.	Tobramycin (Nebcin)
4.	Erythromycin (Erycette)
5.	Colistin (Coly-Mycin)
6.	gentamicin-polymethylmethacrylate bead
7.	Mercox
8.	Bone Cements (Bone Glue)
9.	Silicones
10.	Polypropylenes (Polypropylene)

Related Therapies and Procedures

1.	Fracture Fixation
2.	External Fixators
3.	Vertebroplasty
4.	Transplants (Transplant)
5.	Intraocular Lenses (Intraocular Lens)