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Paraneoplastic Polyneuropathy

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A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. Pathologically, there are inflammatory changes in peripheral nerves. The most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (Adams et al., Principles of Neurology, 6th ed, p1334)

Also Known As:

Paraneoplastic Neuropathy; Neuropathies, Paraneoplastic; Neuropathies, Paraneoplastic Peripheral; Neuropathy, Paraneoplastic Peripheral; Paraneoplastic Neuropathies; Paraneoplastic Peripheral Neuropathies; Paraneoplastic Polyneuropathies; Peripheral Neuropathies, Paraneoplastic; Polyneuropathies, Paraneoplastic; Neuropathy, Paraneoplastic; Paraneoplastic Peripheral Neuropathy; Peripheral Neuropathy, Paraneoplastic; Polyneuropathy, Paraneoplastic

Networked: 38 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Myasthenia Gravis
2.	Mononeuropathies (Mononeuritis Multiplex)
3.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
4.	Neoplasms (Cancer)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Antoine, J-C: 4 articles (10/2014 - 02/2004)
2.	Kaps, M: 3 articles (09/2010 - 12/2005)
3.	Blaes, F: 3 articles (09/2010 - 12/2005)
4.	Tschernatsch, M: 3 articles (09/2010 - 12/2005)
5.	Camdessanché, Jean-Philippe: 2 articles (04/2012 - 01/2002)
6.	Honnorat, Jérôme: 2 articles (04/2012 - 01/2002)
7.	Antoine, Jean-Christophe: 2 articles (04/2012 - 01/2002)
8.	Honnorat, J: 2 articles (01/2011 - 02/2001)
9.	Dalmau, J: 2 articles (01/2011 - 07/2008)
10.	Gilhus, N E: 2 articles (01/2011 - 09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paraneoplastic Polyneuropathy:

1.	Intravenous Immunoglobulins (IVIG)FDA Link 09/01/2008 - "The efficacy of IVIG has been proven in Guillain-Barré syndrome (level A), chronic inflammatory demyelinating polyradiculoneuropathy (level A), multifocal mononeuropathy (level A), acute exacerbations of myasthenia gravis (MG) and short-term treatment of severe MG (level A recommendation), and some paraneoplastic neuropathies (level B). " 12/01/2012 - "Finally, it appears that the use of IVIg has a beneficial effect also in stiff-person syndrome (level A), some paraneoplastic neuropathies (level B), and some acute-demyelinating diseases and childhood refractory epilepsy (good practice point)." 10/01/2014 - "In addition to definitive therapy for malignancy, immunomodulatory therapy, such as corticosteroids, IV immunoglobulin (IVIg), or immunosuppressants, may benefit some patients, but there are very few published treatment data for paraneoplastic neuropathies. "
2.	AntibodiesIBA 01/01/1994 - "The constellation of findings were indicative of paraneoplastic neuropathy, which was confirmed with the appropriate antibody studies demonstrating antineuronal nuclear antibodies. " 01/01/2013 - "Anti-onconeural anti-Hu and anti-CV2/CRMP antibodies allow when they are detected the diagnosis of paraneoplastic neuropathies. " 09/14/2010 - "Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies." 09/14/2010 - "We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). " 09/14/2010 - "Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy."
3.	AutoantibodiesIBA 12/01/2005 - "The clinical and immunological features of 36 patients with paraneoplastic neuropathy from the authors' database were analysed including the type and course of the neuropathy, associated tumours, and the presence of antineuronal and other autoantibodies. " 10/01/2005 - "Paraneoplastic peripheral neuropathy is sometimes associated with unidentified neuronal autoantibodies. " 04/01/1992 - "Several autoantibodies have been reported in paraneoplastic neuropathies. " 04/01/1992 - "[Carcinomatous autonomic neuropathy and the autoantibodies in paraneoplastic neuropathy]." 10/01/2011 - "The presence of paraneoplastic autoantibodies, especially anti-Hu and anti-CV2/CRMP-5 antibodies, may support the diagnosis of paraneoplastic neuropathy. "
4.	AntigensIBA 11/01/2004 - "These results indicate that GS may represent onconeural antigens in paraneoplastic neuropathy (PNN); their expression on neoplastic tissue may elicit autoimmune responses, which also target neural structures." 04/01/1992 - "Further investigation should reveal more glycoconjugate antigens as targets of possible auto-immune attack in paraneoplastic neuropathies." 10/01/2014 - "Antibodies directed to intracellular neural antigens have been mainly described in paraneoplastic peripheral neuropathies and mostly includes anti-Hu and anti-CV2/CRMP5 antibodies. " 11/01/2004 - "Gangliosides act as onconeural antigens in paraneoplastic neuropathies." 02/01/2004 - "Definite paraneoplastic neuropathies correspond to neuropathies associated with antibodies reacting with antigens common to the peripheral nervous system and the cancer. "
5.	Immunoglobulins (Immunoglobulin)IBA 01/01/2012 - "There is only evidence from case series, case reports or expert opinion (class IV evidence) for the effect of immunomodulation (intravenous immunoglobulin, plasma exchange, steroid treatment or chemotherapy) on paraneoplastic neuropathy. " 10/01/2014 - "In addition to definitive therapy for malignancy, immunomodulatory therapy, such as corticosteroids, IV immunoglobulin (IVIg), or immunosuppressants, may benefit some patients, but there are very few published treatment data for paraneoplastic neuropathies. "
6.	Semaphorin-3AIBA 04/01/2012 - "Collapsin response mediator protein 5 (CRMP5) is one of the rare peripheral nerve antigens that is a target of autoantibodies in a paraneoplastic peripheral neuropathy. "
7.	Paclitaxel (Taxol)FDA LinkGeneric 07/01/1994 - "The findings observed in taxol-induced neuropathy are important to document for comparison with other neoplastic and paraneoplastic neuropathies affecting patients with cancer."
8.	SynaptophysinIBA 06/15/2008 - "Synaptophysin is an autoantigen in paraneoplastic neuropathy."
9.	Calcium Channels (Calcium Channel)IBA 02/01/1996 - "The clinical symptoms were thought to be consistent with paraneoplastic neuropathy, and high antineuronal and anti-calcium channel antibodies led to the diagnosis of small-cell carcinoma of the lung. "
10.	Neostigmine (Neostigmine Bromide)IBA 03/01/2003 - "Repeated neostigmine dosage as palliative treatment for chronic colonic pseudo-obstruction in a patient with autonomic paraneoplastic neuropathy."

Therapies and Procedures

1.	Immunomodulation 01/01/2012 - "There is only evidence from case series, case reports or expert opinion (class IV evidence) for the effect of immunomodulation (intravenous immunoglobulin, plasma exchange, steroid treatment or chemotherapy) on paraneoplastic neuropathy. " 10/01/2014 - "In addition to definitive therapy for malignancy, immunomodulatory therapy, such as corticosteroids, IV immunoglobulin (IVIg), or immunosuppressants, may benefit some patients, but there are very few published treatment data for paraneoplastic neuropathies. "
2.	Drug Therapy (Chemotherapy) 10/01/2011 - "The presence of paraneoplastic neuropathy should be considered in all patients with malignancy and can occur at any point in the disease, even during or after chemotherapy, radiation, or stem cell transplantation. " 01/01/2012 - "There is only evidence from case series, case reports or expert opinion (class IV evidence) for the effect of immunomodulation (intravenous immunoglobulin, plasma exchange, steroid treatment or chemotherapy) on paraneoplastic neuropathy. "
3.	Stem Cell Transplantation 10/01/2011 - "The presence of paraneoplastic neuropathy should be considered in all patients with malignancy and can occur at any point in the disease, even during or after chemotherapy, radiation, or stem cell transplantation. "
4.	Transplants (Transplant) 07/01/2008 - "Some lesser known syndromes such as the immune reconstitution inflammatory syndrome and paraneoplastic neuropathies related with PTLD are increasingly being described and need to be considered in the evaluation of a transplant patient with neurological problems."
5.	Plasmapheresis 12/01/1991 - "Results of plasmapheresis on myasthenic crisis, Guillain-Barre syndrome (GBS) and paraneoplastic polyneuropathy are presented. "