Aquaporins (Water Channels)

07/15/2015 - "Additionally, we report here that T3 suppresses the expression of aquaporin-4 (AQP4) water channels which could be a likely mechanism of its anti-edema activity. "
05/01/2014 - "Molecular regulation leading to edema will likely also differ, such that treatments which have been suggested for non-hemorrhagic moderate TBI, such as the suppression of aquaporins, may be detrimental in more severe forms of TBI."
05/01/2014 - "Therefore, AQP9 and the AQP4 M1 isoform may be regulated by HIF1α, but not AQP4 isoform 3. This delayed loss of aquaporins may markedly reduce the ability of the brain to efflux water, contributing to the protracted edema that is a characteristic following severe penetrating TBI. "
10/11/2012 - "Aquaporins (AQPs) provide a unique opportunity to examine the mechanisms underlying water mobility, which remain poorly understood in the juvenile post-traumatic edema process. "
09/01/2011 - "Water transport through aquaporins (AQPs) has been suggested to facilitate the development of ischemic edema in the retina. "

05/01/2015 - "Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. "
03/01/2015 - "This case report deals with multiple intracranial metastatic tumors and studies of expression and regulation characteristics of aquaporins (AQPs) of cerebellar metastatic tumor and brain tissue surrounding tumor. "
01/01/2015 - "Several studies have revealed that aquaporins play a role in tumor progression and invasion. "
01/01/2014 - "Recent studies suggested that aquaporins 5 (AQP5) was associated with many kinds of cancers and regulated many processes of various kinds of cancer cells. "
01/01/2014 - "Further study is required to determine whether aquaporins have potential as prognostic factors in cervical cancer."

04/01/2011 - "This review focuses on water shift and oedema in acute brain injury, with particular aspects on pathophysiology of water movements, the role of aquaporins and the potential of new therapies. "
01/01/2010 - "Effect of secondary insults upon aquaporin-4 water channels following experimental cortical contusion in rats."
05/01/2014 - "Early inhibition of water channels may have positive effects in prevention of edema formation in brain injuries but at later time points during the course of a disease, AQP is critical for clearance of water from the brain into blood vessels. "
06/22/2015 - "Aquaporins and blood-brain barrier permeability in early edema development after traumatic brain injury."
09/01/2013 - "Recently, it has been reported that one of the water channels, aquaporin-4 (AQP4) is seemed to have a role in astroglial migration and glial scar formation caused by brain injury, although its molecular mechanism is largely unknown. "

06/10/2013 - "Cellular overexpression of aquaporins slows down the natural HIF-2α degradation during prolonged hypoxia."
06/03/2013 - "Of the three aquaporin (Aqp) water channels, Aqp-9 was down-regulated, and Aqp-1 was up-regulated during hypoxia. "
04/02/2013 - "During flooding, a rapid drop of cytosolic pH due to anoxia leads to a simultaneous closure of the aquaporins in the plasma membrane. "
11/01/2008 - "Anoxia treatment significantly reduced the effect of nitrate on xylem root hydraulic conductivity indicating an important role for aquaporins in this process. "
07/15/2015 - "We find that nematodes lacking aquaporin water channels in tissues that interface with the surrounding environment display decreased edema formation and improved survival rates in anoxia. "

11/01/2012 - "SI in ARDS could improve oxygenation, lung compliance, and airway resistance, which was related to the improved degree of inflammation and better maintained aquaporins."
10/01/2008 - "Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. "
05/16/2014 - "Rapid changes in cell volume characterize macrophage activation, but the role of water channels in inflammation remains unclear. "
09/01/2009 - "Primary or inflammation-related abnormalities in water channels contribute to the exocrinopathy. "
04/01/2009 - "Members of the aquaporin (AQP) family of transmembrane water channels are targets of regulation in models of lung injury and inflammation. "