Necrotizing Enterocolitis

04/01/2014 - "There is an intense interest among neonatal caregivers as to whether lactoferrin given enterally may reduce the incidence of necrotizing enterocolitis in preterm infants. "
04/01/2014 - "Lactoferrin and necrotizing enterocolitis."
03/01/2014 - "Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial."
03/01/2013 - "Lactoferrin and necrotizing enterocolitis."
01/01/2012 - "Mother's milk, feeding strategies, and lactoferrin to prevent necrotizing enterocolitis."

04/01/2015 - "Necrotizing enterocolitis occurred less frequently in the liberal oxygen group. "
04/01/2015 - "Necrotizing enterocolitis occurred more frequently in infants on restricted oxygen (RR, 1.24 [95% CI, 1.05-1.47]). "
11/01/2011 - "To report the use of near-infrared spectroscopic monitoring to recognize mesenteric oxygen desaturations in a preterm neonate with necrotizing enterocolitis as well as the demonstration of reassuring mesenteric tissue perfusion in a twin sibling with an uncomplicated course. "
11/01/2011 - "Mesentric oxygen saturations in premature twins with and without necrotizing enterocolitis."
01/01/2007 - "At 4 weeks of age, the infant developed necrotizing enterocolitis in association with significant mesenteric oxygen desaturation, as measured by means of near-infrared spectroscopy. "

01/01/2001 - "Searches were made of the Oxford Database of Perinatal trials, MEDLINE (1966 - June 2000; search terms: necrotizing enterocolitis, antibiotics; limits: newborn infant), previous reviews with cross references, abstracts, conference and symposia proceedings, expert informants and journal hand searching in the fields of neonatal pediatrics and microbiology. "
01/01/2000 - "Searches were made of the Oxford Database of Perinatal trials, MEDLINE (search terms: necrotizing enterocolitis, antibiotics; newborn infant), previous reviews with cross references, abstracts, conference and symposia proceedings, expert informants and journal handsearching in the fields of Neonatal Pediatrics and Microbiology. "
09/24/1997 - "In the total study population, the primary outcome (44.1 % vs 52.9%; P=.04), respiratory distress (40.5% vs 48.7%; P=.04), and necrotizing enterocolitis (2.3% vs 5.8%; P=.03) were less frequent with antibiotics. "
01/01/2014 - "Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets."
01/01/2012 - "The appropriate use of antibiotics for preterm infants, which are highly susceptible to develop necrotizing enterocolitis (NEC), is not clear. "

11/01/1980 - "A randomized, controlled study of oral gentamicin in the treatment of neonatal necrotizing enterocolitis."
12/01/1978 - "The value of prophylactic oral gentamicin sulfate therapy in the prevention of necrotizing enterocolitis (NEC) was evaluated in a group of 42 high-risk neonates over a four-month period in a randomized, double-blind controlled trial. "
12/01/1984 - "Fifty-two preterm neonates receiving oral gentamicin from birth, as prophylaxis against necrotizing enterocolitis (NEC), had serum gentamicin levels measured on the second day of life (52 infants) and on the seventh to tenth days (43 infants). "
01/01/1984 - "Gentamicin absorption during prophylactic use for necrotizing enterocolitis."
12/01/1978 - "Oral gentamicin therapy in the prevention of neonatal necrotizing enterocolitis. "

11/01/1998 - "Prevention of necrotizing enterocolitis in extremely low birth weight infants by IgG feeding?"
07/07/1988 - "Among the infants for whom breast milk did not become available during the study, there were no cases of necrotizing enterocolitis among the 88 receiving oral IgA-IgG, as compared with six cases among the 91 control infants (P = 0.0143). "
07/07/1988 - "Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA-IgG feeding."
07/07/1988 - "We conclude that the oral administration of IgA-IgG may prevent the development of necrotizing enterocolitis in low-birth-weight infants."
11/01/1990 - "Prophylaxis of necrotizing enterocolitis by oral IgA-IgG: review of a clinical study in low birth weight infants and discussion of the pathogenic role of infection."

02/01/1983 - "A highly significant increase in IgA levels (p less than 0.001) was seen in neonates with gastrointestinal anomalies and necrotizing enterocolitis while patients with low anorectal anomalies and spina bifida had normal or undetectable IgA levels. "
07/07/1988 - "Among the infants for whom breast milk did not become available during the study, there were no cases of necrotizing enterocolitis among the 88 receiving oral IgA-IgG, as compared with six cases among the 91 control infants (P = 0.0143). "
07/07/1988 - "Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA-IgG feeding."
07/07/1988 - "We conclude that the oral administration of IgA-IgG may prevent the development of necrotizing enterocolitis in low-birth-weight infants."
11/01/1990 - "Prophylaxis of necrotizing enterocolitis by oral IgA-IgG: review of a clinical study in low birth weight infants and discussion of the pathogenic role of infection."

10/01/2014 - "Similarly, among infants with BW >1500 g, the 17 (9 %) with ROP only differed from the 166 (91 %) without ROP with respect to a higher incidence of necrotizing enterocolitis among those with ROP (11.8 % vs 0 %). "
05/01/1994 - "Statistical analysis, corrected for correlations, showed that the occurrence of ROP was related significantly to early intubation, hypotension, persistent ductus arteriosus and necrotizing enterocolitis."
01/01/2013 - "Birth weight (P < .001), gestational age (P < .001), mechanical ventilation therapy (P = .039), and necrotizing enterocolitis (P = .019) were independent risk factors for ROP. "
10/01/2014 - "For the overall cohort, regression analysis found that birth weight (OR: 0.741 per 100 g; 95 % CI: 0.606, 0.905), gestational age at birth (OR: 0.563 per week; 95 % CI: 0.454, 0.697), multiple gestation (OR 2.02, 95 % CI: 1.15, 3.56), bronchopulmonary dysplasia (OR: 4.68, 95 % CI: 1.93, 11.35), and necrotizing enterocolitis (OR 2.80, 95 % CI: 1.40, 5.16) were independent risk factors for treatment-requiring ROP. "
10/01/2013 - "Bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and necrotizing enterocolitis (NEC) all likely involve oxidative damage to immature tissues. "

02/01/2015 - "In keeping with animal studies, small clinical trials of L-arginine supplementation have shown benefit in reducing necrotizing enterocolitis in premature neonates. "
01/01/2014 - "Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review."
09/01/2013 - "Enteral L-arginine supplementation for prevention of necrotizing enterocolitis in very low birth weight neonates: a double-blind randomized pilot study of efficacy and safety."
12/01/2012 - "We tried to evaluate the effectiveness of inhaled NO compared to L-arginine usage in necrotizing enterocolitis model in rats. "
08/01/2007 - "As plasma L-arginine concentrations are decreased in premature infants with necrotizing enterocolitis (NEC), we hypothesized that the CPS1 T1405N polymorphism would correlate with the presence of NEC. "

07/01/2014 - "Glutamine downregulates TLR-2 and TLR-4 expression and protects intestinal tract in preterm neonatal rats with necrotizing enterocolitis."
05/01/2004 - "Glutamine had no effect on tolerance of enteral feeds, necrotizing enterocolitis, or growth. "
10/01/2011 - "To examine the impact of oral glutamine (Gln) supplementation on gut integrity and on the incidence of necrotizing enterocolitis (NEC)/septicemia of premature neonates. "
10/01/2011 - "The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates."
01/01/2003 - "The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis."

11/01/2005 - "In this prospective, observational study, we determined whether serum C-reactive protein (CRP) correlated with necrotizing enterocolitis (NEC) stages II and III. We hypothesized that serial CRP measurement if used as an adjunct to abdominal radiographs would improve the identification of infants with NEC. "
11/01/2005 - "C-reactive protein in the diagnosis, management, and prognosis of neonatal necrotizing enterocolitis."
01/01/1994 - "In the latter group, C-reactive protein also proved to be a good parameter with statistical significance respecting the severity of necrotizing enterocolitis."
01/01/2013 - "Necrotizing enterocolitis (NEC) and the risk of intestinal stricture: the value of C-reactive protein."
02/01/2012 - "Age, parity, gestational age of PPROM and delivery, latency period, oligohydramnios, white blood cell (WBC) count and serum C-reactive protein (CRP) level at admission and before delivery, the incidence of neonatal respiratory distress syndrome (NRDS), neonatal pneumonia, bronchopulmonary dysplasia, necrotizing enterocolitis, early-onset neonatal sepsis, abnormal brain sonography findings and mortality were compared between two groups. "

09/01/1995 - "A study is presented utilizing the critical decision method to elicit knowledge from neonatal intensive care unit nurses regarding the assessment of infants at risk for necrotizing enterocolitis. "
09/06/1980 - "A study was undertaken to evaluate the predisposing factors, age at the time of onset and prognosis of neonatal necrotizing enterocolitis in 62 patients treated in a neonatal intensive care unit during a 5-year period (1974-78). "
12/01/2015 - "Necrotizing enterocolitis (NEC) leads to significant morbidity and mortality in the neonatal intensive care unit. "
01/01/2015 - "Necrotizing enterocolitis is an acute inflammatory disease, which primarily affects preterm infants, and is a leading cause of morbidity and mortality in the neonatal intensive care unit. "
12/01/2014 - "In 2002, an outbreak of necrotizing enterocolitis in a Canadian neonatal intensive care unit was associated with a proposed novel species of Clostridium, "Clostridium neonatale." To date, there are no data about the isolation, identification, or clinical significance of this species. "

01/01/2016 - "Infants in the high dose group had a higher number of median ventilator days (53.5 vs. 45.6days, p=0.046) and a higher incidence of necrotizing enterocolitis (5% vs. 21.7%, p=0.022). "
01/01/1998 - "In the first case, the neonate developed pneumoperitonium when weaning from the ventilator and was submitted to the operation with clinical diagnosis of Necrotizing Enterocolitis. "
11/01/1995 - "The remainder of the data revealed no statistically significant differences in preterm delivery rate, necrotizing enterocolitis, respiratory distress syndrome, intraventricular haemorrhage rate or severity of haemorrhage, hospital days, latency to delivery, or ventilator days. "
03/01/2003 - "There appeared to be less necrotizing enterocolitis in group II. The average length of hospital stay was 14 days less for group II. The use of a preformed silo initially followed by delayed fascial closure in infants with gastroschisis is associated with improved fascial closure rates, fewer ventilator days, more rapid return of bowel function, and fewer complications compared with attempts at initial early repair."
10/01/2007 - "Three infants had associated problems including prematurity, respiratory distress syndrome type 1, necrotizing enterocolitis, mechanical ventilator support, and one of them had tracheaesophageal fistula. "

10/01/2014 - "Primary laparotomy is effective and safe in the treatment of necrotizing enterocolitis."
08/01/2014 - "This study sought to quantify mortality associated with laparotomy-confirmed SIP and to compare it to mortality of laparotomy-confirmed necrotizing enterocolitis (NEC). "
08/01/2009 - "The aim of the study was to evaluate the effect of disease site on the mortality rate of newborns with necrotizing enterocolitis (NEC) undergoing exploratory laparotomy. "
05/25/2006 - "We designed this multicenter randomized trial to compare outcomes of primary peritoneal drainage with laparotomy and bowel resection in preterm infants with perforated necrotizing enterocolitis. "
03/01/2001 - "The aim of this study was to identify and assess mortality predictive factors in newborns with necrotizing enterocolitis (NEC) requiring emergency exploratory laparotomy. "

12/01/2015 - "We hypothesized that supplemental parenteral nutrition (PN) decreases the need for surgery and mortality associated with necrotizing enterocolitis (NEC). "
12/01/2015 - "The effect of supplemental parenteral nutrition on outcomes of necrotizing enterocolitis in premature, low birth weight neonates."
09/01/2014 - "The primary outcome and neonatal morbidities showed no significant difference, only the incidence of necrotizing enterocolitis and the use of parenteral nutrition showed significant difference. "
07/01/2014 - "Principal outcomes were mortality, necrotizing enterocolitis (NEC), growth, and duration of parenteral nutrition (PN). "
05/01/2014 - "This retrospective study compared the effectiveness of an education-based quality improvement project and the relationship of time of the first EF to necrotizing enterocolitis (NEC) or death incidence and parenteral nutrition (PN) days in VLBW infants. "

07/01/2009 - "Prophylactic surgical ligation of PDA resulted in a statistically significant reduction of severe stage II or III necrotizing enterocolitis, [RR 0.25, 95% CI (0.08, 0.83), P value 0.02, number needed to treat 5]. "
01/01/2008 - "Prophylactic surgical ligation of the PDA resulted in a statistically significant reduction of severe stage II or III necrotizing enterocolitis (NEC), [RR 0.25, 95% CI (0.08,0.83), p value 0.02, NNT 5]. "
10/01/2014 - "Early surgical ligation for the treatment of PDA that failed to close after medical treatment or in cases contraindicated for medical treatment might be desirable to reduce the incidence of necrotizing enterocolitis and to alleviate feeding intolerance in preterm infants."
06/08/1989 - "Among the infants who were fed within 14 days of birth, those who underwent prophylactic ligation had a lower incidence of necrotizing enterocolitis (1 of 11 [9 percent]) than those who did not (13 of 24 [54 percent]; P = 0.001). "
06/08/1989 - "The incidence of necrotizing enterocolitis was reduced in the group that underwent prophylactic ligation (3 of 40 [8 percent]) as compared with the control group (13 of 44 [30 percent]; P = 0.002). "