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Hypertensive Encephalopathy

Brain dysfunction or damage resulting from sustained MALIGNANT HYPERTENSION. When BLOOD PRESSURE exceeds the limits of cerebral autoregulation, cerebral blood flow is impaired (BRAIN ISCHEMIA). Clinical manifestations include HEADACHE; NAUSEA; VOMITING; SEIZURES; altered mental status (in some cases progressing to COMA); PAPILLEDEMA; and RETINAL HEMORRHAGE.
Also Known As:
Encephalopathy, Hypertensive
Networked: 187 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Headache (Headaches)
2. Pheochromocytoma
3. Purpura
4. Hypertension (High Blood Pressure)
5. Seizures (Absence Seizure)

Experts

1. Pietranera, Luciana: 4 articles (05/2019 - 04/2008)
2. Brocca, Maria Elvira: 3 articles (05/2019 - 12/2010)
3. De Nicola, Alejandro F: 3 articles (02/2015 - 04/2008)
4. Edvardsson, Bengt: 2 articles (09/2015 - 01/2015)
5. Garcia-Segura, Luis Miguel: 2 articles (02/2015 - 12/2010)
6. Lima, Analia: 2 articles (02/2015 - 04/2008)
7. Roig, Paulina: 2 articles (02/2015 - 04/2008)
8. Brocca, M E: 2 articles (10/2012 - 02/2011)
9. De Nicola, A F: 2 articles (10/2012 - 02/2011)
10. Garcia-Segura, L M: 2 articles (10/2012 - 02/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertensive Encephalopathy:
1. cytoflavinIBA
01/01/2014 - "To evaluate the efficacy of cytoflavin in the treatment of patients with hypertensive encephalopathy (HE). "
01/01/2014 - "[Efficacy of the energy-modifier cytoflavin in the treatment of patients with hypertensive encephalopathy]."
01/01/2020 - "To study the characteristics of main clinical and diagnostic indicators of cerebral venous circulation and their dynamics in patients with hypertensive encephalopathy of various stages treated with cytoflavin. "
01/01/2020 - "The patients who received cytoflavin in the treatment regimen showed a slight improvement on the 30th day and a significant improvement in venous cerebral circulation indicators on the 60th day (p<0,05), which made it possible to conclude that the drug is effective for improving cerebral venous hemodynamics, and to recommend it in the complex therapy of patients with hypertensive encephalopathy of various stages with existing venous cerebral disorders. "
01/01/2014 - "The molecular pharmacological effects of cytoflavin in patients with hypertensive encephalopathy (HE) and isolated systolic arterial hypertension (ISAH) have been investigated using the following methods: assessment of complaints, 24-hour arterial pressure monitoring, ultrasound diagnostics including echocardiography, measurement of lipid profiles and coagulograms, and molecular phenotyping by MALDI-TOF/TOF-MS. A combination of cytoflavin administration with standard therapy of HE and ISAH led to the most expressed return development of clinical symptoms, restoration of the hemodynamic, structural, and geometrical parameters of cardiovascular system, and normalization of the indices of lipid profiles and coagulograms in comparison to patients with HE and ISAH, which accepted only standard therapy. "
2. Estradiol (Delestrogen)FDA LinkGeneric
3. Zonisamide (Zonegran)FDA LinkGeneric
4. Antihypertensive Agents (Antihypertensives)IBA
5. ErythropoietinFDA Link
6. CollagenIBA
7. Blood Proteins (Serum Proteins)IBA
8. Extracellular Matrix ProteinsIBA
9. SolutionsIBA
10. Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Critical Care (Surgical Intensive Care)
3. Renal Dialysis (Hemodialysis)
4. Intravenous Infusions
5. Cesarean Section (Caesarean Section)