Spastic Paraparesis

Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.

Also Known As:

Networked: 225 relevant articles (7 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neurologic Manifestations (Neurological Manifestations)
2.	Multiple Sclerosis
3.	Spinal Cord Ischemia
4.	Ataxia (Dyssynergia)
5.	Cataract (Cataracts)

Experts

1.	Kakinohana, Manabu: 6 articles (03/2007 - 11/2002)
2.	Sugahara, Kazuhiro: 5 articles (04/2006 - 11/2002)
3.	Hardy, J: 5 articles (11/2001 - 03/2000)
4.	Kalimo, H: 4 articles (07/2008 - 03/2000)
5.	Verkkoniemi, A: 4 articles (07/2008 - 03/2000)
6.	Nakamura, Seiya: 4 articles (04/2006 - 11/2002)
7.	Abramsky, Oded: 3 articles (10/2015 - 02/2006)
8.	Lossos, Alexander: 3 articles (10/2015 - 02/2006)
9.	Paetau, A: 3 articles (07/2008 - 11/2000)
10.	Crook, R: 3 articles (11/2001 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spastic Paraparesis:

1.	Botulinum Toxins (Botulinum Toxin)IBA 02/01/2007 - "In an open label study, we analyzed the efficacy of botulinum toxin injection at the lower limbs of patients with hereditary spastic paraparesis (HSP). " 02/01/2007 - "Botulinum toxin injection in patients with hereditary spastic paraparesis." 03/01/1995 - "[Treatment of spastic paraparesis with botulinum toxin with reference to beneficial effects, disease severity and long-term treatment]." 06/01/1992 - "We treated three patients with spastic paraparesis with botulinum toxin (BTX). " 08/01/2010 - "Botulinum toxin injections for pediatric patients with hereditary spastic paraparesis."
2.	BaclofenFDA LinkGeneric 10/01/2007 - "Some patients with hereditary spastic paraparesis have good functional improvement with chronic intrathecal delivery of baclofen if walking is still possible. " 10/01/2007 - "[Intrathecal baclofen in hereditary spastic paraparesis: benefits and limitations]." 02/25/2000 - "The covariation between thigh, shank and foot elevation angles during locomotion was analysed by means of orthogonal planar regression in a patient with pure hereditary spastic paraparesis before and after an intrathecal bolus of baclofen and in seven healthy subjects. " 02/25/2000 - "Effect of intrathecal baclofen on gait control in human hereditary spastic paraparesis." 09/01/1992 - "Muscle tone and deep-tendon reflexes were evaluated in three patients with hereditary spastic paraparesis after a double-blind, cross-over bolus injection of intrathecal baclofen. "
3.	Oligoclonal BandsIBA 03/01/1989 - "Ten of the 11 patients with positive results had a chronic spastic paraparesis with IgG oligoclonal bands and elevated HTLV-I antibody index. " 09/01/1990 - "All of the TSP/HAM cases exhibited a spastic paraparesis with a chronic and slow evolution and high HTLV-I antibody titers in serum and cerebrospinal fluid, with a high HTLV-I antibody index and specific HTLV-I immunoglobulin = oligoclonal bands. "
4.	Prednisolone (Predate)FDA LinkGeneric 04/01/1992 - "[Spastic paraparesis and sensory disturbance improved by prednisolone therapy]."
5.	Biotin (Vitamin H)FDA Link 03/01/1992 - "After a period of 2 months of oral substitution with biotin 10 mg per day the visual field defects improved as well as the distal spastic parapareses and motor neuropathy. "
6.	Morphine (MS Contin)FDA LinkGeneric 03/01/2003 - "Intrathecal administration of morphine, but not small dose, induced spastic paraparesis after a noninjurious interval of aortic occlusion in rats." 11/01/2002 - "The purpose of this study was to investigate interactions between morphine and GABAergic agonists or antagonists on motor function after spinal cord ischemia and then clarify the mechanism of the spastic paraparesis induced by intrathecal morphine. " 11/01/2002 - "In this study, we investigate interactions between morphine and GABAergic agonists or antagonists on motor function after spinal cord ischemia and then clarified the mechanism of the spastic paraparesis induced by intrathecal morphine. " 03/01/2003 - "We sought to investigate the dose-response relationship for the effect of intrathecal morphine on the transient spastic paraparesis after short-lasting spinal ischemia in rats. " 11/01/2002 - "We have previously demonstrated that intrathecal morphine given after a noninjurious interval of spinal cord ischemia induced transient spastic paraparesis in a rodent model. "
7.	Spastic paraplegia 17IBA 02/01/2015 - "Silver syndrome/spastic paraplegia 17 is an autosomal dominant, complicated hereditary spastic paraparesis in which spasticity of the legs is accompanied by amyotrophy of the hands and occasionally also the lower limbs. " 06/01/2008 - "Silver syndrome (SPG17) is a rare form of hereditary spastic paraparesis. " 02/01/2006 - "Mutations in the BSCL2 gene have recently been identified in families with (SPG17-linked) Silver syndrome-type hereditary spastic paraparesis as well as in families with distal hereditary motor neuropathy (HMN). " 03/01/2004 - "Silver syndrome (OMIM #270685) is a rare form of hereditary spastic paraparesis mapped to chromosome 11q12-q14 (SPG17) in which spasticity of the legs is accompanied by amyotrophy of the hands and occasionally also the lower limbs. " 12/01/2003 - "Silver syndrome is a rare variant of autosomal dominant complicated hereditary spastic paraparesis (HSP), in which spasticity of the lower limbs is accompanied by amyotrophy of the hands and occasionally also the lower limbs. "
8.	DNA (Deoxyribonucleic Acid)IBA 01/01/1996 - "In the present study we examined the presence of HTLV-I provirus genomic DNA by nested polymerase chain reaction (PCR) and by DNA hybridization in mouthwash samples obtained from 13 Mashhadi-born Iranian Jews with spastic paraparesis associated with HTLV-I, 4 Mashhadi-born Iranian Jews asymptomatic carriers for HTLV-I and 21 healthy controls. " 09/20/2002 - "Failure to detect HTLV type 1 DNA from HTLV type 1-seronegative patients with chronic progressive spastic paraparesis in Kagoshima." 11/01/1993 - "None of the non-Mashhadi Iranian Jews was seropositive or PCR-positive for HTLV-I proviral DNA, or had clinical signs of spastic paraparesis.(ABSTRACT TRUNCATED AT 250 WORDS)" 05/01/1991 - "Amplifications of multiple regions of the HTLV-I genome from DNA of an Italian spastic paraparesis patient but not from DNA of multiple sclerosis patients." 08/15/1988 - "DNA blotting analysis of human retroviruses in cerebrospinal fluid of spastic paraparesis patients: the viruses are identical to human T-cell leukemia virus type-1 (HTLV-1)."
9.	Type A Botulinum Toxins (Botulinum A Toxin)FDA Link 12/01/2000 - "Botulinum toxin type-A treatment in spastic paraparesis: a neurophysiological study." 01/01/2007 - "[The application of botulinum toxin type A in the treatment of spastic paraparesis]." 01/01/2007 - "The introduction of botulinum toxin type A (BTX-A) has brought a new approach to the treatment for spasticity and pain connected, in the patients with spastic paraparesis in course of multiple sclerosis, posttraumatic and angiogenic lesion of brain and spinal cord. "
10.	VitaminsIBA 01/01/1956 - "[Effect of the administration of nicotinic amide on spastic paraparesis probably caused by a vitamin disorder]." 04/01/1969 - "[Therapeutic trials of a new drug association (corticoids, phosphorylcholamine and vitamins) in some forms of spastic paraparesis]."

Therapies and Procedures

1.	Injections 05/01/2005 - "In conclusion, short-term NS accelerates the effectiveness of intramuscular BTXA injections on the neuromuscular blockade in patients with spastic paraparesis and could induce a rapid and persistent improvement in spasticity. " 03/01/1995 - "In conclusion, the beneficial effects of botulinum injections to spastic paraparesis were (1) improvement of objective symptoms in mild cases, (2) improvement of ADL in moderate cases, and (3) improvement of objective symptoms and ease of nursing care in severe cases. " 08/01/2010 - "Botulinum toxin injections for pediatric patients with hereditary spastic paraparesis." 03/01/1995 - "We administered local botulinum toxin injections on the leg adductors of 12 patients with spastic paraparesis (9 patients with HAM, 2 patients with spinal spastic paraparesis, 1 patient with an identified degenerative disease). "
2.	Liver Transplantation 03/01/2008 - "One patient experienced improved neurologic symptoms after liver transplantation, whereas the other patient only received medical treatment, which did not prevent the progression of spastic paraparesis."
3.	Rhizotomy 01/01/2014 - "In this study selective dorsal rhizotomy (SDR) was performed to improve the spasticity of pure hereditary spastic paraparesis and the long-term results were followed. " 01/01/2014 - "Long-term results of selective dorsal rhizotomy for hereditary spastic paraparesis." 11/01/1981 - "The effect of selective posterior lumbar rhizotomy on the evolution of cerebropathic spastic paraparesis was particularly impressive. " 01/01/2015 - "Selective dorsal rhizotomy (SDR) is often recommended for children with spastic paraparesis and cerebral palsy. " 07/01/1982 - "In 18 patients in whom the clinical picture showed spastic paraparesis a posterior selective lumbar rhizotomy was performed: 3 patients with disabling spastic tetraparesis underwent posterior cervical C1-C3 rhizotomy. "
4.	Decompression 11/01/1997 - "Neurosurgical decompression therapy was, therefore, performed to alleviate his spastic paraparesis. " 01/01/2011 - "The first patient who underwent delayed decompression showed good healing of the TB lesion but continued to have spastic paraparesis with kyphosis. " 09/01/2006 - "Six months after posterior fossa decompression there was the disappearance of nuchal rigidity, vertigo, spastic paraparesis and improvement of balance. " 02/01/1983 - "Spastic paraparesis or quadriparesis, severe nuchal immobility and pain, and flaccid paresis of the upper limbs necessitated anterior medullary decompression and posterior cervical fusion. "
5.	Surgical Portasystemic Shunt (Portosystemic Shunt) 12/01/2012 - "Spastic paraparesis due to portosystemic shunts was diagnosed. " 10/01/1991 - "Postshunt myelopathy is a rare, severely debilitating syndrome complicating portosystemic shunts that is characterized by spastic paraparesis. " 01/01/2006 - "Hepatic myelopathy (HM) is a rare complication of chronic liver diseases usually associated with a portosystemic shunt, causing a progressive spastic paraparesis, and is likely to be overlooked. "