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Glaucoma Drainage Implants

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Devices, usually incorporating unidirectional valves, which are surgically inserted in the sclera to maintain normal intraocular pressure.

Also Known As:

Aqueous Humor Shunts; Aqueous Humor Shunt; Aqueous Shunt; Drainage Implant, Glaucoma; Drainage Implants, Glaucoma; Filtration Implant, Glaucoma; Filtration Implants, Glaucoma; Glaucoma Drainage Implant; Glaucoma Filtration Implant; Implant, Glaucoma Drainage; Implant, Glaucoma Filtration; Implants, Baerveldt; Implants, Glaucoma Drainage; Implants, Glaucoma Filtration; Shunt, Aqueous; Shunt, Aqueous Humor; Shunts, Aqueous; Shunts, Aqueous Humor; Valves, Krupin; Aqueous Shunts; Baerveldt Implants; Glaucoma Filtration Implants; Krupin Valves

Networked: 129 relevant articles (9 outcomes, 6 trials/studies)

Relationship Network

Therapy Context: Research Results

Equipment and Supplies
- Prostheses and Implants: 13222
  - Glaucoma Drainage Implants: 129
    - Molteno Implants: 35

Experts

1.	Budenz, Donald L: 10 articles (02/2015 - 08/2002)
2.	Gedde, Steven J: 8 articles (02/2015 - 08/2002)
3.	Barton, Keith: 6 articles (02/2015 - 06/2007)
4.	Buys, Yvonne M: 4 articles (10/2015 - 03/2011)
5.	Feuer, William J: 4 articles (02/2015 - 03/2011)
6.	Schiffman, Joyce: 4 articles (02/2015 - 03/2011)
7.	Ahmed Baerveldt Comparison Study Group: 4 articles (02/2015 - 03/2011)
8.	Park, Chan Kee: 3 articles (06/2015 - 05/2013)
9.	Flynn, Harry W: 3 articles (06/2015 - 09/2003)
10.	Miller, Darlene: 3 articles (06/2015 - 09/2003)

Related Diseases

1.	Glaucoma 12/01/2003 - "Aqueous shunt implantation offers a significantly greater chance of successful glaucoma control in the first 2 years of life, compared with trabeculectomy with MMC. " 01/01/2002 - "Aqueous shunts were relatively effective in this series of infants with recalcitrant glaucoma." 05/01/2009 - "Molteno and Baerveldt glaucoma drainage implants surgery seems to be safe and effective treatment for primary and secondary pediatric glaucoma refractive to the initial surgical procedure and medical therapy." 01/01/2009 - "Ahmed and Baerveldt implants are a safe and effective procedure for lowering the IOP in the management of refractory glaucoma." 11/01/2007 - "Molteno and Baerveldt glaucoma drainage implants surgery seems to be safe and effective treatment for primary and secondary pediatric glaucoma refractory to the initial surgical procedure and medical therapy."
2.	Cataract (Cataracts) 02/01/2004 - "To examine the safety and efficacy of combined phacoemulsification and glaucoma drainage implant surgery in providing reduction of intraocular pressure (IOP) and visual rehabilitation in eyes with refractory glaucoma and cataract. " 06/01/2015 - "Of the 10 study patients who were identified, clinical settings included trabeculectomy bleb-associated (n = 3), post-cataract surgery (n = 2), post-penetrating keratoplasty (n = 2), post-scleral buckle (n = 1), glaucoma drainage implant-associated (n = 1), and post-keratoprosthesis (n = 1). " 04/01/2004 - "Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery." 02/01/2004 - "For subjects with refractory glaucoma and cataract, combined phacoemulsification and glaucoma drainage implant surgery provide good visual rehabilitation and control of IOP, with low incidence of complications." 02/01/2004 - "Surgical outcomes of combined phacoemulsification and glaucoma drainage implant surgery for Asian patients with refractory glaucoma with cataract."
3.	Blister (Bulla) 06/01/2015 - "Serial changes in the bleb wall after glaucoma drainage implant surgery: characteristics during the hypertensive phase." 06/01/2015 - "In the 12 patients identified, clinical settings included postcataract surgery (n = 4), postpenetrating keratoplasty (n = 3), endogenous source (n = 2), post-pars plana vitrectomy (n = 1), trabeculectomy bleb-associated setting (n = 1), and glaucoma drainage implant-associated setting (n = 1). " 09/01/2014 - "Immunohistochemical analysis of extracellular matrix bleb capsules of functioning and non-functioning glaucoma drainage implants." 01/01/2014 - "Combined Baerveldt glaucoma drainage implant surgery and surgical bleb revision for preventing a postoperative hypertensive phase." 05/01/2013 - "Visualization of blebs using anterior-segment optical coherence tomography after glaucoma drainage implant surgery."
4.	Fibrosis (Cirrhosis) 03/01/2014 - "After placement of aqueous shunts, a significant decrease in IOP was noted from preoperatively (Day -1) to Day 28 despite fibrosis surrounding the implants. " 02/01/2000 - "This experimental study was conducted to report perfusion characteristics of small diameter, cylindrical aqueous shunts in normal rabbit eyes and to test the hypothesis that decreasing bleb diameter would decrease capsular fibrosis, as evidenced by a thinner capsule forming around the implant. " 01/01/2013 - "Ocular fibroblast types differ in their mRNA profiles--implications for fibrosis prevention after aqueous shunt implantation." 05/01/2011 - "As a basis for developing an aqueous shunt we report here investigations with poly(3-hydroxybutyrate) (P(3HB)) and poly(4-hydroxybutyrate) (P(4HB)) as polymer matrices and with paclitaxel (PTX) and triamcinolone acetonide (TA) as drugs that might, in combination, delay or prevent the process of fibrosis by reducing fibroblast activity. "
5.	Hypertension (High Blood Pressure) 05/01/1994 - "Modification of the glaucoma drainage implant to prevent early postoperative hypertension and hypotony: a laboratory study."

Related Drugs and Biologics

1.	Ice
2.	Guanine Nucleotide Dissociation Inhibitors (GDIs)
3.	Mitomycin (Mitomycin-C)
4.	tranilast (N 5')
5.	Matrix Metalloproteinases
6.	Tissue Inhibitor of Metalloproteinase-3
7.	Tissue Inhibitor of Metalloproteinases (TIMP)
8.	Paclitaxel (Taxol)
9.	Cyclosporine (Ciclosporin)
10.	Triamcinolone Acetonide (Azmacort)

Related Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty)
2.	Phacoemulsification
3.	Penetrating Keratoplasty
4.	Filtering Surgery
5.	Lasers (Laser)