Migraine without Aura (Common Migraine)

Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Also Known As:

Networked: 381 relevant articles (26 outcomes, 80 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Migraine with Aura (Familial Hemiplegic Migraine)
2.	Headache (Headaches)
3.	Migraine Disorders (Migraine)
4.	Epilepsy (Aura)
5.	Migraine without Aura (Common Migraine)

Experts

1.	Olesen, J: 16 articles (05/2013 - 07/2000)
2.	Olesen, Jes: 9 articles (08/2012 - 05/2002)
3.	de Tommaso, Marina: 8 articles (08/2013 - 06/2004)
4.	Livrea, Paolo: 6 articles (08/2014 - 08/2005)
5.	Russell, Michael Bjørn: 5 articles (01/2014 - 05/2002)
6.	Guido, Marco: 5 articles (09/2008 - 06/2004)
7.	Thomsen, L L: 5 articles (12/2004 - 07/2004)
8.	Nappi, Giuseppe: 4 articles (05/2015 - 01/2002)
9.	Serpino, Claudia: 4 articles (03/2012 - 10/2007)
10.	Tfelt-Hansen, P: 4 articles (11/2010 - 11/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Migraine without Aura:

1.	Propranolol (Inderal)FDA LinkGeneric 12/01/2004 - "Two subjects fulfilled IHS criteria 1.1 for migraine without aura after propranolol but not after placebo. " 06/29/1974 - "Forty-nine patients with either classic or common migraine were treated with propranolol 160 mg/day for an average of six months. " 04/01/1993 - "Thirty patients with severe classical and common migraine participated in a double-blind placebo-controlled cross-over study of migraine prophylaxis with propranolol LA (long-acting) 80 mg once daily, or propranolol LA 160 mg once daily or placebo. " 10/01/1990 - "We present the first double-blind placebo controlled study of propranolol in 27 unselected patients with common (migraine without aura) and classical (migraine with aura) migraine. " 09/01/1991 - "The efficacy of the beta-adrenoceptor antagonist propranolol in the acute treatment of patients in attacks of either classical (migraine with aura) or common migraine (migraine without aura) headache was assessed in a double-blind placebo-controlled crossover trial with fixed doses. "
2.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 06/01/2013 - "Acupuncture versus valproic acid in the prophylaxis of migraine without aura: a prospective controlled study." 04/01/1994 - "We included 43 patients with migraine without aura in a triple-blind, placebo- and dose-controlled, crossover study of the prophylactic effect of slow-release sodium valproate; 34 patients completed the trial. " 05/01/2013 - "He was diagnosed as having migraine without aura and successfully treated with valproic acid. " 04/01/1994 - "We conclude that sodium valproate is an effective and well-tolerated prophylactic medication for migraine without aura." 04/01/1994 - "Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study."
3.	Sumatriptan (Imigran)FDA LinkGeneric 03/01/2014 - "This study aims to evaluate the efficacy of ginger in the ablation of common migraine attack in comparison to sumatriptan therapy. " 07/01/1997 - "We conducted an open study on the efficacy of 50 mg of sumatriptan as an acute treatment for migraine without aura. " 03/01/2014 - "Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine." 07/01/1997 - "Sumatriptan in the acute treatment of migraine without aura: efficacy of 50-mg dose." 03/01/2014 - "The effectiveness of ginger powder in the treatment of common migraine attacks is statistically comparable to sumatriptan. "
4.	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/01/2010 - "Blockade of nitric oxide synthases (NOS) by L-nitromonomethylarginine effectively treats attacks of migraine without aura. " 03/01/2000 - "Many reports indicate that nitric oxide (NO) could be involved in migraine without aura (MWA), an extremely diffuse clinical event. " 02/16/2010 - "Compared to patients with migraine with aura (MA) and migraine without aura (MO), patients with familial hemiplegic migraine (FHM) without known gene mutations display a reduced sensitivity to nitric oxide. " 11/01/2008 - "Blockade of nitric oxide synthases (NOS) by L-NMMA effectively treats attacks of migraine without aura. " 01/01/2007 - "A total of 56 subjects (22 migraine without aura, 14 migraine with aura, and 20 age- and sex-matched healthy controls) were included in the study and nitric oxide (NO) metabolites, malondialdehyde (MDA), and thiol (SH) groups were measured in platelets. "
5.	Timolol (Blocadren)FDA LinkGeneric 02/01/1987 - "Timolol maleate, a beta blocker, in the treatment of common migraine headache." 01/01/1986 - "In a multicentre study including 96 patients calculation of 95% confidence limits demonstrated that timolol and propranolol are equally effective in common migraine prophylaxis. " 01/01/1984 - "It is concluded that timolol and propranolol are equally effective in the used doses (1:8) for common migraine prophylaxis." 01/01/1984 - "Common migraine sufferers (25 males, 71 females) with a history of 2-6 attacks per month participated in a 4-centre trial comparing the prophylactic effect of timolol (10 mg b.i.d.) and propranolol (80 mg b.i.d.) to placebo. " 01/01/1984 - "Timolol vs propranolol vs placebo in common migraine prophylaxis: a double-blind multicenter trial."
6.	Diclofenac (SR 38)FDA LinkGeneric 04/01/1992 - "Trial of oral diclofenac for the acute treatment of common migraine attacks." 05/01/1991 - "A hundred and seven patients suffering from migraine without aura were included, and 91 were analysed for efficacy; they had to treat four successive attacks--two with diclofenac and two with placebo. " 05/01/1991 - "Effectiveness of oral diclofenac in the acute treatment of common migraine attacks: a double-blind study versus placebo." 06/01/2002 - "60 patients with migraine with aura and 60 patients with migraine without aura were assigned at random to receiving intramuscular diclofenac, 75 mg associated to intravenous physiological saline, 10 ml, or physiological saline alone. " 06/01/2002 - "Patients receiving diclofenac showed a statistically significant improvement of pain 60 minutes after the administration in two of the three parameters(migraine without aura) and in all parameters (migraine with aura). "
7.	FlunarizineIBA 01/01/2009 - "We design and perform a randomized controlled clinical trial to evaluate the efficacy of acupuncture compared with flunarizine in the prophylactic therapy of patients with migraine without aura in China. " 03/01/1986 - "A placebo-controlled, double-blind, cross-over trial of flunarizine in common migraine." 05/01/1985 - "Flunarizine in common migraine: Italian cooperative trial. " 05/01/1985 - "Flunarizine in common migraine: Italian cooperative trial. " 07/01/2004 - "We investigated the antimigraine activity of flunarizine and its influence on NO and oxidative marker bioavailability in 25 subjects suffering from migraine without aura and in 25 healthy controls. "
8.	Naproxen (Naprosyn)FDA LinkGeneric 03/01/1989 - "Naproxen was compared with placebo in a double-blind, crossover trial in classic and common migraine. " 03/01/1985 - "Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study. " 03/01/1985 - "Naproxen sodium proved safe and effective in common migraine attacks, but in this study efficacy was not established for classical migraine." 05/01/2007 - "We investigated the biological and clinical effects of naproxen sodium (NxS) in the short-term prophylaxis of pure menstrual migraine (PMM) in 25 women suffering from migraine without aura, occurring exclusively from 2 days before to 5 days after menstruation onset. " 03/01/1985 - "Patients suffering from common migraine had less severe headaches and photophobia when taking naproxen sodium than when taking placebo and the headaches were shorter in duration and patients took less rescue analgesic. "
9.	Dihydroergotamine (Agit)FDA LinkGeneric 06/01/1987 - "We have compared the efficacy of dihydroergotamine (DHE) nasal spray with that of placebo in patients with classic or common migraine attacks. " 04/01/2005 - "Studies in which dihydroergotamine (alone or in combination with an antiemetic) was compared with placebo or any other common migraine therapy were considered. " 04/01/1995 - "We studied the efficacy, safety, and tolerability of dihydroergotamine nasal spray as monotherapy in the acute treatment of classic and common migraine in two, identical, double-blind, randomized, placebo-controlled trials. " 08/01/1983 - "In this multicentric random double-blind study versus placebo, the therapeutic activity of timed-release dihydroergotamine preparation 10 mg/per os/day has been tested in 90 patients affected by common migraine. " 08/01/1983 - "Planned release dihydroergotamine in common migraine and "tension-vascular headache": multicentre clinical trial."
10.	SodiumIBA 03/01/1985 - "Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study. " 03/01/1985 - "Naproxen sodium proved safe and effective in common migraine attacks, but in this study efficacy was not established for classical migraine." 05/01/2007 - "We investigated the biological and clinical effects of naproxen sodium (NxS) in the short-term prophylaxis of pure menstrual migraine (PMM) in 25 women suffering from migraine without aura, occurring exclusively from 2 days before to 5 days after menstruation onset. " 03/01/1985 - "Patients suffering from common migraine had less severe headaches and photophobia when taking naproxen sodium than when taking placebo and the headaches were shorter in duration and patients took less rescue analgesic. " 04/01/2014 - "This study was conducted to evaluate the efficacy and tolerability of sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura. "

Therapies and Procedures

1.	Ear Acupuncture 11/01/2012 - "To assess objectively the efficacy of migraine without aura treated by comprehensive auricular acupuncture. " 11/01/2012 - "[Migraine without aura treated by comprehensive auricular acupuncture: a multicentral controlled study]." 01/01/2012 - "This study compares the clinical effectiveness of somatic and ear acupuncture for treatment of migraine without aura. " 01/01/2012 - "These results, though preliminary, are quite promising in supporting the effectiveness of ear acupuncture for treatment of migraine without aura." 11/01/2012 - "The comprehensive auricular acupuncture reduces apparently the headache score for migraine without aura and relieves the clinical symptoms of migraine. "
2.	Contraception (Birth Control) 12/01/2014 - "Progestin-only contraception compared with extended combined oral contraceptive in women with migraine without aura: a retrospective pilot study." 01/01/2014 - "The aim of the present study was to investigate the influence of contraception on the attacks of migraine without aura (MO) in women with MM. 141 women from the general population with a history of MM according to the International Classification of Headache Disorders II (ICHD II) were interviewed by a headache specialist. " 10/01/2011 - "To compare the efficacy of two regimens (21 active pills + 7 placebo pills vs. 24 active pills + 4 placebo pills) of combined oral contraception (COC), both containing 20 μg of ethinyl E(2) and 3 mg of drospirenone, in improving the severity of pure menstrual migraine without aura. " 12/01/2014 - "To evaluate the effect of a desogestrel progestogen-only pill (POP) compared to continuous combined oral contraception (COC) on migraine patterns in women with migraine without aura. "
3.	Lasers (Laser) 12/01/2009 - "The aim of the study was to examine the features of laser evoked potentials (LEPs), including habituation, in women suffering from migraine without aura versus healthy controls, during the pre-menstrual and late luteal phases. " 01/01/2013 - "Scalp potentials were evoked by Nd-YAP Laser stimulation of the hand dorsum and supraorbital region in 13 patients with migraine without aura (MO) and 15 healthy volunteers (HV). " 03/01/2012 - "The aim of the study was to evaluate the effect of visual and verbal suggestion on subjective pain sensation and cortical responses evoked by CO2 painful laser stimuli in migraine without aura patients vs healthy controls. " 10/01/2005 - "The aim of this study was to perform a topographic and dipolar analysis of nociceptive-evoked responses obtained by laser stimulus under basal conditions in a cohort of chronic migraine (CM) patients, compared with migraine without aura (MWA) patients and noncraniofacial pain controls. " 06/17/2004 - "Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials."
4.	Aftercare (After-Treatment) 07/01/2002 - "After treatment, amplitude changes were -9.3% +/- 14.5% in migraine without aura and -10.1% +/- 11.5% in migraine with aura. " 01/01/2010 - "The aim of this study was to compare the recovery cycle of somatosensory evoked potentials (SEPs) in children with migraine without aura before and after treatment with topiramate. " 03/01/2008 - "We studied the excitability of the visual and motor cortex in 36 patients with frequent migraine without aura (30 women, mean age 38.6 +/- 10.0 years) before and after treatment with topiramate (100 mg/day) using transcranial magnetic stimulation. "
5.	Gas Lasers 08/12/2005 - "The aim of this study was to compare the properties of the nociceptive system in eight migraine without aura patients in the pain-free phase with 10 healthy controls, by evaluating the topography and the source of the CO2 laser-evoked potentials (LEPs) obtained by the right supraorbital skin, during and after capsaicin topical application. "