Central Nervous System Fungal Infections

MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).

Also Known As:

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Meningitis
2.	Infection

Experts

1.	Antinori, Spinello: 1 article (12/2014)
2.	Milazzo, Laura: 1 article (12/2014)
3.	Corbellino, Mario: 1 article (12/2014)
4.	Llinas, Rafael: 1 article (01/2014)
5.	Nelson, George: 1 article (01/2014)
6.	Fermo, Olga: 1 article (01/2014)
7.	Thakur, Kiran: 1 article (01/2014)
8.	Rhee, Susan: 1 article (01/2014)
9.	Bang, Jee: 1 article (01/2014)
10.	Johnson, Kristine: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Central Nervous System Fungal Infections:

1.	Itraconazole (Sporanox)FDA LinkGeneric 03/01/2006 - "Parenteral Amphotericin B, followed by prolonged itraconazole therapy, remains the "gold standard" modality for central nervous system fungal infections in adjunct to aggressive surgical debridement."
2.	Amphotericin B (Amphotericin)FDA LinkGeneric 03/01/2006 - "Parenteral Amphotericin B, followed by prolonged itraconazole therapy, remains the "gold standard" modality for central nervous system fungal infections in adjunct to aggressive surgical debridement."
3.	MethylprednisoloneFDA LinkGeneric 01/01/2014 - "The 2012 outbreak of central nervous system fungal infections associated with contaminated methylprednisolone produced by a United States compounding pharmacy has led to 750 infections (151 with meningitis and paraspinal infections and 325 cases with paraspinal infections without meningitis) and 64 deaths as of October 23, 2013. "
4.	posaconazoleFDA Link 10/01/2005 - "Activity of posaconazole in the treatment of central nervous system fungal infections."

Therapies and Procedures

1.	Debridement 03/01/2006 - "Parenteral Amphotericin B, followed by prolonged itraconazole therapy, remains the "gold standard" modality for central nervous system fungal infections in adjunct to aggressive surgical debridement."
2.	Transplants (Transplant) 12/01/2014 - "Diagnosis of central nervous system mycoses in solid organ transplant recipients."
3.	Hematopoietic Stem Cell Transplantation 07/01/2008 - "Central nervous system fungal infections (FI) are important complications and a cause of mortality in patients who receive hematopoietic stem cell transplantation (HSCT). "
4.	Drug Therapy (Chemotherapy) 01/01/1974 - "Current and future chemotherapy of central nervous system fungal infections."