Choroid Plexus Papilloma

A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)

Also Known As:

Networked: 185 relevant articles (4 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Neoplasm Metastasis (Metastasis)
3.	Neoplasms (Cancer)
4.	Ependymoma
5.	Choroid Plexus Neoplasms (Choroid Plexus Tumor)

Experts

1.	Jeibmann, Astrid: 5 articles (10/2014 - 01/2006)
2.	Hasselblatt, Martin: 5 articles (10/2014 - 01/2006)
3.	Wrede, Brigitte: 5 articles (10/2009 - 11/2005)
4.	Ishikawa, Hiroshi: 4 articles (09/2015 - 09/2004)
5.	Paulus, Werner: 4 articles (10/2009 - 01/2006)
6.	Schroten, Horst: 3 articles (09/2015 - 01/2012)
7.	Schwerk, Christian: 3 articles (09/2015 - 01/2012)
8.	Bouffet, Eric: 3 articles (01/2015 - 04/2010)
9.	Beschorner, R: 3 articles (08/2013 - 12/2009)
10.	Schittenhelm, J: 3 articles (08/2013 - 12/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Choroid Plexus Papilloma:

1.	3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)IBA 12/01/2009 - "Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. " 09/01/2013 - "Choroid plexus papilloma (CPP) is extremely rare in the brainstem. " 09/01/2012 - "Choroid plexus papillomas (CPP) are most commonly found in children and rarely in adult. " 09/01/2011 - "Cystic choroid plexus papilloma (CPP) of the third ventricle is rare. " 01/01/2011 - "Choroid plexus papilloma (CPP) can develop at a primary intraparenchymal location completely unrelated to the ventricular system. "
2.	cytidylyl-(3'-5')-cytidine (CpC)IBA 02/01/2014 - "We reviewed the treatment outcome of 23 children, focusing on the biological behavior of the atypical choroid plexus papilloma (ACPP) and the current therapeutic strategy in choroid plexus carcinoma (CPC). " 04/20/2010 - "High-resolution single nucleotide polymorphism (SNP) array analysis revealed extremely high total structural variation (TSV) in TP53-mutated CPC tumor genomes compared with TP53 wild-type tumors and choroid plexus papillomas (CPPs; P = .006 and .004, respectively). " 07/01/2015 - "We performed a retrospective study on clinical assessment, tumor location, radiological imaging, histopathological characteristics, and therapeutic management of 7 patients affected by choroid plexus carcinoma (CPC) or atypical choroid plexus papilloma (ACPP) who have been observed in the last 12 years. " 07/01/1999 - "Our systematic and detailed cellular IP analyses of 82 childhood brain tumors [34 medulloblastomas (MEDs)/primitive neuroectodermal tumors (PNETs), 42 astrocytomas (ASTRs), 5 choroid plexus papillomas (CPPs) and 1 choroid plexus carcinoma (CPC)], was conducted using over 55 MoABs. " 02/01/2014 - "The median age at diagnosis was 18 months--55 months for choroid plexus papilloma (CPP), 8 months for ACPP, and 15 months for CPC. "
3.	Lomustine (CCNU)FDA Link 09/01/2000 - "Evidence of therapeutic efficacy of CCNU in recurrent choroid plexus papilloma."
4.	Tumor Viral Antigens (Large T Antigen)IBA 04/01/2005 - "Immunohistochemical studies revealed nuclear expression of the large T-antigen in a choroid plexus papilloma. " 09/01/1993 - "A transgenic mouse carrying the SV40 regulatory region and JC virus (JCV) T-antigen-coding sequences exhibited an SV40-characteristic choroid plexus papilloma that expressed JCV T-antigen and p53. " 07/01/1991 - "Earlier studies have indicated that the most consistent effect of large-T antigen expression is the formation of choroid plexus papillomas in the brain and that thymic hyperplasia and various kidney abnormalities are less frequently observed. " 01/01/1978 - "Two tumours (an ependymoma and a choroid plexus papilloma) of ependymal origin revealed markedly positive nuclear staining for T antigen both in in vivo and in vitro. " 01/15/1978 - "Two tumors of ependymal origin (malignant ependymoma, choroid plexus papilloma) revealed markedly positive nuclear staining for T antigen both in vivo and in vitro. "
5.	Glial Fibrillary Acidic ProteinIBA 01/01/1981 - "We therefore tested 22 choroid plexus papillomas for the presence of glial fibrillary acidic (GFA) protein using the immunoperoxidase technique. " 01/01/2001 - "Glial fibrillary acidic protein can be found focally in about 25-55% of choroid plexus papillomas and 20% of choroid plexus carcinomas. " 01/01/1988 - "An immunohistochemical study of cytokeratin and glial fibrillary acidic protein in choroid plexus papilloma." 01/01/1988 - "Cellular localization of cytokeratin and glial fibrillary acidic protein (GFAP) was examined in two normal choroid plexuses and five choroid plexus papillomas by the peroxidase-antiperoxidase (PAP) method and double immunofluorescence (IFL) microscopy. " 01/01/1992 - "The immunohistological findings using antibodies to different intermediate filaments (glial fibrillary acidic protein, vimentin and two types of cytokeratin) and epithelial membrane antigen are described in 89 gliomas, 19 meningiomas and 8 choroid plexus papillomas (CPPs) from adult patients. "
6.	Prealbumin (Transthyretin)IBA 09/01/1988 - "Choroid plexus papillomas: an immunohistochemical study with particular reference to the coexpression of prealbumin." 09/01/1988 - "This report is the first to describe the usefulness of prealbumin reactivity for histological diagnosis of choroid plexus papillomas." 01/01/2006 - "Transthyretin stained choroid plexus (33 of 35), choroid plexus papilloma (14 of 18), and plexus carcinoma (2 of 5), but its specificity was significantly lower. " 06/01/2010 - "Congophilic birefringent amyloid deposits, with immunostaining for transthyretin (TTR) and amyloid P, associated with numerous coarse, enlarged and thick elastic fibres, are reported in the stroma of two choroid plexus papillomas, a finding not previously described in choroid plexus tumours. " 09/01/1992 - "The findings of pathological examinations such as hematoxylin and eosin staining, transthyretin (prealbumin) immunoreactivity, and electron microscopy were consistent with choroid plexus papilloma. "
7.	Keratins (Keratin)IBA 05/01/1986 - "Keratin was immunohistochemically found in three of four choroid plexus papillomas, two of two choroid plexus carcinomas, and the lining cells of three neuroepithelial cysts. " 01/01/1988 - "An immunohistochemical study of cytokeratin and glial fibrillary acidic protein in choroid plexus papilloma." 01/01/1988 - "Cellular localization of cytokeratin and glial fibrillary acidic protein (GFAP) was examined in two normal choroid plexuses and five choroid plexus papillomas by the peroxidase-antiperoxidase (PAP) method and double immunofluorescence (IFL) microscopy. " 07/01/1998 - "The choroid plexus papilloma was strongly positive for epithelial membrane antigen (EMA), keratin, S-100 protein and vimentin, and positive for GFAP in places. " 01/01/1992 - "The immunohistological findings using antibodies to different intermediate filaments (glial fibrillary acidic protein, vimentin and two types of cytokeratin) and epithelial membrane antigen are described in 89 gliomas, 19 meningiomas and 8 choroid plexus papillomas (CPPs) from adult patients. "
8.	S100 Proteins (S 100 Protein)IBA 01/01/2001 - "Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III. Immunohistochemically, cytokeratins and vimentin are expressed by virtually all choroid plexus papillomas and most choroid plexus carcinomas while transthyretin and S-100 protein are present in 80-90% of cases, less frequently, though, in choroid plexus carcinomas. " 07/01/1998 - "The choroid plexus papilloma was strongly positive for epithelial membrane antigen (EMA), keratin, S-100 protein and vimentin, and positive for GFAP in places. " 01/01/1986 - "Immunostaining patterns of two glia-associated proteins, glial fibrillary acidic protein (GFAP) and S-100 protein (S100P), were compared using the peroxidase-antiperoxidase (PAP) method on adjacent paraffin sections in 100 brain tumors including 52 astroglial tumors, 13 oligodendrogliomas, 14 ependymomas, 13 choroid plexus papillomas and 8 medulloblastomas. " 07/01/1989 - "Eleven benign and five malignant choroid plexus papillomas in children and adults were studied immunohistologically with a panel of antibodies against glial fibrillary acidic protein, S-100 protein, vimentin, desmin, epithelial membrane antigen and two different cytokeratins (LP34 and CAM 5.2). " 12/01/1991 - "An immunohistochemical study of glial fibrillary acidic protein (GFAP), S-100 protein, cytokeratin (CKER), epithelial membrane antigen (EMA), and transthyretin (TTR) was carried out on 11 cases of choroid plexus papilloma (CPP) and 19 of ependymoma, using the peroxidase antiperoxidase technique. "
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/1987 - "Report on Feulgen-cytophotometric DNA studies of 8 choroid plexus papillomas. " 01/01/1987 - "DNA pattern in choroid plexus papillomas." 03/15/2009 - "On DNA microarray data analysis, 53 probe sets were differentially expressed in choroid plexus papilloma tumor cells (>7-fold). " 01/01/2006 - "To identify specific markers for the diagnosis of choroid plexus tumors, gene expression profiles of choroid plexus epithelial cells (n = 8) and ependymal cells (n = 6) microdissected from human autopsy brains as well as choroid plexus papilloma tissue were investigated using DNA microarrays. " 04/01/2005 - "Genomic DNA sequences were isolated from 62 brain tumors (32 medulloblastomas, 18 ependymomas, five choroid plexus papillomas, and seven pilocytic astrocytomas) and analyzed for the presence of JC virus DNA by Southern blot hybridization and direct sequencing. "
10.	Mucin-1 (CA 15-3 Antigen)IBA 07/01/1998 - "The choroid plexus papilloma was strongly positive for epithelial membrane antigen (EMA), keratin, S-100 protein and vimentin, and positive for GFAP in places. " 01/01/1992 - "The immunohistological findings using antibodies to different intermediate filaments (glial fibrillary acidic protein, vimentin and two types of cytokeratin) and epithelial membrane antigen are described in 89 gliomas, 19 meningiomas and 8 choroid plexus papillomas (CPPs) from adult patients. " 07/01/1989 - "Eleven benign and five malignant choroid plexus papillomas in children and adults were studied immunohistologically with a panel of antibodies against glial fibrillary acidic protein, S-100 protein, vimentin, desmin, epithelial membrane antigen and two different cytokeratins (LP34 and CAM 5.2). " 12/01/1991 - "An immunohistochemical study of glial fibrillary acidic protein (GFAP), S-100 protein, cytokeratin (CKER), epithelial membrane antigen (EMA), and transthyretin (TTR) was carried out on 11 cases of choroid plexus papilloma (CPP) and 19 of ependymoma, using the peroxidase antiperoxidase technique. " 01/01/1994 - "Immunohistochemical analysis of 9 choroid plexus papillomas (CPPs) and 3 choroid plexus carcinomas (CPCs) using a panel of antibodies against glial fibrillary acidic protein (GFAP), cytokeratin (CK), epithelial membrane antigen (EMA), S-100 protein, vimentin (vim), and neuron specific enolase (NSE) is presented. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/2016 - "Choroid plexus papilloma-A case highlighting the challenges of extrapolating pediatric chemotherapy regimens to adult populations." 07/01/2006 - "There is no consensus on the most effective treatment for choroid plexus papilloma metastases; surgical resection, chemotherapy, and radiation therapy may all yield benefits. " 10/01/1986 - "Four had progressive tumor or metastatic deposits, (one medulloblastoma, one malignant choroid plexus papilloma, and two were not explored) but responded to chemotherapy. "
2.	Adjuvant Chemotherapy 10/01/2009 - "Efficacy of multi-staged surgery and adjuvant chemotherapy for successful treatment of atypical choroid plexus papilloma in an infant: case report." 06/01/2009 - "The histological diagnoses of these tumors were astrocytoma, n = 3; pineocytoma, n = 2; teratoma, n = 1; ependymoma, n = 1; atypical teratoid/rhabdoid tumor, n = 1; glioblastoma, n = 1; medulloblastoma, n = 1; and choroid plexus papilloma, n = 1. Surgical resection was performed in eight patients, and adjuvant chemotherapy was administered to all except one patient with choroid plexus papilloma. "
3.	Radiotherapy 01/01/1977 - "Preoperative radiotherapy in the management of posterior fossa choroid plexus papillomas." 01/01/1985 - "Surgery and biopsy is diagnostic, and radiotherapy has been used as the treatment of choice for choroid plexus carcinoma (CPC) and recurrent choroid plexus papilloma (CPP). "
4.	Ventriculoperitoneal Shunt 11/01/2003 - "The proposed etiology of ascites in these cases was peritoneal metastasis from thalamic glioblastoma through ventriculoperitoneal shunt in first case, excessive production of CSF by choroid plexus papilloma in second, infection in the third case and craniopharyngioma causing excessive production of CSF in the fourth child. "
5.	Cranial Irradiation 09/01/1998 - "We report a case of multiple parietal cavernous malformations in a thirteen year old female who received cranial irradiation following incomplete resection of a choroid plexus papilloma. " 09/01/1998 - "Bilateral cavernous malformations resulting from cranial irradiation of a choroid plexus papilloma."